YHR122W / CIA2

Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR122W / CIA2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:2.98|P-value:6.33E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.23|P-value:2.36E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.43|P-value:1.37E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.61|P-value:6.46E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.22|P-value:2.52E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.21|P-value:3.32E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.68|P-value:3.55E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.92|P-value:9.87E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-4.03|P-value:9.57E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.52|P-value:7.19E-5 ID:SGTC_442|Compound:cape|FD-Score:2.94|P-value:7.39E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.37|P-value:1.36E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.83|P-value:2.40E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.27|P-value:2.05E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.35|P-value:1.44E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-5.60|P-value:1.30E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:2.92|P-value:7.89E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.02|P-value:6.84E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:2.90|P-value:8.47E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.11|P-value:3.89E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:2.96|P-value:6.65E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.30|P-value:1.78E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.11|P-value:3.82E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.11|P-value:4.63E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.57|P-value:5.69E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:2.07E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.89|P-value:1.32E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.14|P-value:4.36E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.92|P-value:7.93E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.54|P-value:6.39E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.08|P-value:4.23E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.11|P-value:4.99E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.21|P-value:2.59E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.44|P-value:1.35E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.88|P-value:1.95E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.57|P-value:7.56E-5 ID:SGTC_1855|Compound:st056195|FD-Score:4.66|P-value:2.55E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.46|P-value:1.21E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.21|P-value:2.55E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.05|P-value:4.77E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.09|P-value:5.32E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.04|P-value:6.35E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.50|P-value:1.03E-4 ID:SGTC_2396|Compound:5342950|FD-Score:2.99|P-value:6.07E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.51|P-value:9.77E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.08|P-value:5.66E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.24|P-value:8.26E-9 ID:SGTC_2455|Compound:5377712|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.26|P-value:2.11E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.20|P-value:2.66E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.07|P-value:5.80E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.51|P-value:7.27E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.98|P-value:1.22E-5 ID:SGTC_2835|Compound:9006588|FD-Score:7.73|P-value:4.72E-17 ID:SGTC_2845|Compound:9003024|FD-Score:4.13|P-value:4.14E-6 ID:SGTC_2846|Compound:9008642|FD-Score:3.72|P-value:2.99E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-6.84|P-value:1.61E-13 ID:SGTC_2896|Compound:9052656|FD-Score:5.37|P-value:3.70E-9 ID:SGTC_2898|Compound:9056270|FD-Score:-3.10|P-value:5.18E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.49|P-value:8.24E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.85|P-value:2.17E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.54|P-value:8.82E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-4.32|P-value:2.27E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.81|P-value:1.90E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-3.09|P-value:5.26E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.05|P-value:4.88E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.02|P-value:6.88E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.86|P-value:9.59E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.02|P-value:7.09E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.92|P-value:1.18E-5 ID:SGTC_3193|Compound:9111931|FD-Score:2.98|P-value:6.27E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.12|P-value:4.76E-4 ID:SGTC_3307|Compound:9126885|FD-Score:5.12|P-value:1.69E-8 ID:SGTC_10|Compound:0279-0212|FD-Score:2.98|P-value:6.33E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.23|P-value:2.36E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.43|P-value:1.37E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.61|P-value:6.46E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.22|P-value:2.52E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.21|P-value:3.32E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.68|P-value:3.55E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.92|P-value:9.87E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-4.03|P-value:9.57E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.52|P-value:7.19E-5 ID:SGTC_442|Compound:cape|FD-Score:2.94|P-value:7.39E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.37|P-value:1.36E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.83|P-value:2.40E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.27|P-value:2.05E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.35|P-value:1.44E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-5.60|P-value:1.30E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:2.92|P-value:7.89E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.02|P-value:6.84E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:2.90|P-value:8.47E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.11|P-value:3.89E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:2.96|P-value:6.65E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.30|P-value:1.78E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.11|P-value:3.82E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.11|P-value:4.63E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.57|P-value:5.69E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:2.07E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.89|P-value:1.32E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.14|P-value:4.36E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.92|P-value:7.93E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.54|P-value:6.39E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.08|P-value:4.23E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.11|P-value:4.99E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.21|P-value:2.59E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.44|P-value:1.35E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.88|P-value:1.95E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.57|P-value:7.56E-5 ID:SGTC_1855|Compound:st056195|FD-Score:4.66|P-value:2.55E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.46|P-value:1.21E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.21|P-value:2.55E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.05|P-value:4.77E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.09|P-value:5.32E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.04|P-value:6.35E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.50|P-value:1.03E-4 ID:SGTC_2396|Compound:5342950|FD-Score:2.99|P-value:6.07E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.51|P-value:9.77E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.08|P-value:5.66E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.24|P-value:8.26E-9 ID:SGTC_2455|Compound:5377712|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.26|P-value:2.11E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.20|P-value:2.66E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.07|P-value:5.80E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.51|P-value:7.27E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.98|P-value:1.22E-5 ID:SGTC_2835|Compound:9006588|FD-Score:7.73|P-value:4.72E-17 ID:SGTC_2845|Compound:9003024|FD-Score:4.13|P-value:4.14E-6 ID:SGTC_2846|Compound:9008642|FD-Score:3.72|P-value:2.99E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-6.84|P-value:1.61E-13 ID:SGTC_2896|Compound:9052656|FD-Score:5.37|P-value:3.70E-9 ID:SGTC_2898|Compound:9056270|FD-Score:-3.10|P-value:5.18E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.49|P-value:8.24E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.85|P-value:2.17E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.54|P-value:8.82E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-4.32|P-value:2.27E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.81|P-value:1.90E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-3.09|P-value:5.26E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.05|P-value:4.88E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.02|P-value:6.88E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.86|P-value:9.59E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.02|P-value:7.09E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.92|P-value:1.18E-5 ID:SGTC_3193|Compound:9111931|FD-Score:2.98|P-value:6.27E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.12|P-value:4.76E-4 ID:SGTC_3307|Compound:9126885|FD-Score:5.12|P-value:1.69E-8

Top fitness defect scores for YHR122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2835 9006588 7.73 71.4 µM 4.72E-17 1 5.37E-15 1.57
2 SGTC_2896 9052656 5.37 71.4 µM 3.70E-9 endomembrane recycling 15 4.00E-8 0.34
3 SGTC_2437 5741531 5.24 144.2 µM 8.26E-9 3 8.06E-8 1.11
4 SGTC_3307 9126885 5.12 69.3 µM 1.69E-8 3 1.51E-7 0.22
5 SGTC_1855 st056195 4.66 39.6 µM 2.55E-7 60S ribosome export 6 1.60E-6 0.26
6 SGTC_2845 9003024 4.13 43.0 µM 4.14E-6 amide catabolism 13 1.81E-5 0.22
7 SGTC_951 1171-0579 4.11 82.7 µM 4.63E-6 cell wall 19 2.00E-5 0.01
8 SGTC_3192 9110362 3.92 49.5 µM 1.18E-5 mitochondrial processes 6 4.52E-5 0.05
9 SGTC_1144 3486-0183 3.89 12.5 µM 1.32E-5 4 4.98E-5 0.16
10 SGTC_3103 9120822 3.81 49.5 µM 1.90E-5 8 6.85E-5 0.05
11 SGTC_2846 9008642 3.72 19.5 µM 2.99E-5 10 1.02E-4 0.26
12 SGTC_155 k072-0202 3.68 43.6 µM 3.55E-5 7 1.18E-4 0.01
13 SGTC_1084 voriconazole 3.57 435.0 nM 5.69E-5 azole & statin 15 1.78E-4 0.08
14 SGTC_1230 0170-0365 3.54 3.8 µM 6.39E-5 endomembrane recycling 27 1.97E-4 0.04
15 SGTC_440 fluspirilene 3.52 35.1 µM 7.19E-5 3 2.18E-4 0.29
16 SGTC_2816 7982706 3.51 58.4 µM 7.27E-5 azole & statin 18 2.20E-4 0.14
17 SGTC_2937 9044753 3.49 11.3 µM 8.24E-5 60S ribosome export 12 2.46E-4 0.08
18 SGTC_451 chloral hydrate 3.37 100.0 µM 1.36E-4 29 3.80E-4 0.18
19 SGTC_709 3807-1509 3.35 243.0 µM 1.44E-4 RSC complex & mRNA processing 23 3.99E-4 0.04
20 SGTC_138 0850-0259 3.33 40.9 µM 1.58E-4 cell wall 59 4.33E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.04E-21 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.163 2.30E-21 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.145 2.45E-17 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.143 1.03E-16 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 9.49E-16 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.134 7.18E-15 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.127 1.54E-13 YKL141W SDH3 het Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.122 1.16E-12 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.120 3.59E-12 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.119 4.09E-12 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.117 9.31E-12 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.116 1.94E-11 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.112 8.24E-11 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.10E-10 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.111 1.27E-10 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2