YHR124W / NDT80

Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR124W / NDT80

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.22|P-value:6.26E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.82|P-value:5.06E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:4.24|P-value:7.97E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.43|P-value:2.43E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.57|P-value:1.68E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.93|P-value:3.16E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:5.66|P-value:4.41E-9 ID:SGTC_883|Compound:0850-0245|FD-Score:4.57|P-value:1.72E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:5.02|P-value:1.74E-7 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.31|P-value:4.51E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.64|P-value:1.07E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.18|P-value:5.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.97|P-value:2.67E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.19|P-value:6.99E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.83|P-value:4.77E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.34|P-value:3.29E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.46|P-value:2.63E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.97|P-value:3.41E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.26|P-value:4.54E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.14|P-value:8.32E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.17|P-value:6.12E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.75|P-value:6.67E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.72|P-value:9.38E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.12|P-value:7.50E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.64|P-value:1.20E-6 ID:SGTC_1934|Compound:st074720|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.94|P-value:3.01E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.21|P-value:9.49E-6 ID:SGTC_2222|Compound:6885208|FD-Score:-3.12|P-value:8.79E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:4.55|P-value:1.87E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.81|P-value:6.46E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.15|P-value:6.71E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.72|P-value:9.53E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-4.67|P-value:1.34E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.54|P-value:1.55E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:7.16|P-value:1.89E-13 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.35|P-value:3.18E-4 ID:SGTC_2791|Compound:5663188|FD-Score:5.03|P-value:1.60E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-3.72|P-value:9.31E-5 ID:SGTC_2796|Compound:7949634|FD-Score:4.67|P-value:1.03E-6 ID:SGTC_2965|Compound:9082772|FD-Score:4.55|P-value:1.90E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.13|P-value:7.16E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.14|P-value:8.87E-8 ID:SGTC_3109|Compound:9122853|FD-Score:-3.24|P-value:5.88E-4 ID:SGTC_3111|Compound:9122088|FD-Score:4.07|P-value:1.73E-5 ID:SGTC_3115|Compound:9123671|FD-Score:-3.37|P-value:3.62E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.43|P-value:2.40E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.64|P-value:1.22E-6 ID:SGTC_3311|Compound:9131146|FD-Score:-3.87|P-value:5.15E-5 ID:SGTC_3313|Compound:9133968|FD-Score:-3.23|P-value:6.02E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-4.19|P-value:1.29E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.22|P-value:6.26E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.82|P-value:5.06E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:4.24|P-value:7.97E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.43|P-value:2.43E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.57|P-value:1.68E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.93|P-value:3.16E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:5.66|P-value:4.41E-9 ID:SGTC_883|Compound:0850-0245|FD-Score:4.57|P-value:1.72E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:5.02|P-value:1.74E-7 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.31|P-value:4.51E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.64|P-value:1.07E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.18|P-value:5.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.97|P-value:2.67E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.19|P-value:6.99E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.83|P-value:4.77E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.34|P-value:3.29E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.46|P-value:2.63E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.97|P-value:3.41E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.26|P-value:4.54E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.14|P-value:8.32E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.17|P-value:6.12E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.75|P-value:6.67E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.72|P-value:9.38E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.12|P-value:7.50E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.64|P-value:1.20E-6 ID:SGTC_1934|Compound:st074720|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.94|P-value:3.01E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.21|P-value:9.49E-6 ID:SGTC_2222|Compound:6885208|FD-Score:-3.12|P-value:8.79E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:4.55|P-value:1.87E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.81|P-value:6.46E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.15|P-value:6.71E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.72|P-value:9.53E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-4.67|P-value:1.34E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.54|P-value:1.55E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:7.16|P-value:1.89E-13 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.35|P-value:3.18E-4 ID:SGTC_2791|Compound:5663188|FD-Score:5.03|P-value:1.60E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-3.72|P-value:9.31E-5 ID:SGTC_2796|Compound:7949634|FD-Score:4.67|P-value:1.03E-6 ID:SGTC_2965|Compound:9082772|FD-Score:4.55|P-value:1.90E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.13|P-value:7.16E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.14|P-value:8.87E-8 ID:SGTC_3109|Compound:9122853|FD-Score:-3.24|P-value:5.88E-4 ID:SGTC_3111|Compound:9122088|FD-Score:4.07|P-value:1.73E-5 ID:SGTC_3115|Compound:9123671|FD-Score:-3.37|P-value:3.62E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.43|P-value:2.40E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.64|P-value:1.22E-6 ID:SGTC_3311|Compound:9131146|FD-Score:-3.87|P-value:5.15E-5 ID:SGTC_3313|Compound:9133968|FD-Score:-3.23|P-value:6.02E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-4.19|P-value:1.29E-5

Top fitness defect scores for YHR124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 7.16 70.0 µM 1.89E-13 redox potentiating 16 4.04E-13
2 SGTC_874 0599-0792 5.66 117.0 µM 4.41E-9 8 7.36E-9
3 SGTC_3094 9117742 5.14 49.5 µM 8.87E-8 8 1.37E-7
4 SGTC_2791 5663188 5.03 71.4 µM 1.60E-7 RPP1 & pyrimidine depletion 3 2.44E-7
5 SGTC_963 1269-2853 5.02 151.0 µM 1.74E-7 13 2.65E-7
6 SGTC_2796 7949634 4.67 45.5 µM 1.03E-6 10 1.50E-6
7 SGTC_1923 st058458 4.64 19.1 µM 1.20E-6 18 1.74E-6
8 SGTC_3153 9100258 4.64 49.5 µM 1.22E-6 8 1.77E-6
9 SGTC_737 1950-0117 4.57 57.9 µM 1.68E-6 14 2.42E-6
10 SGTC_883 0850-0245 4.57 24.6 µM 1.72E-6 cell wall 20 2.46E-6
11 SGTC_2235 salicylic acid 4.55 500.0 µM 1.87E-6 4 2.68E-6
12 SGTC_2965 9082772 4.55 38.6 µM 1.90E-6 mitochondrial response to ROS 27 2.72E-6
13 SGTC_621 3584-0052 4.24 32.1 µM 7.97E-6 21 1.10E-5
14 SGTC_2187 6125751 4.21 200.0 µM 9.49E-6 RSC complex & mRNA processing 12 1.30E-5
15 SGTC_3111 9122088 4.07 49.5 µM 1.73E-5 4 2.34E-5
16 SGTC_1129 3453-1384 4.05 223.0 µM 1.89E-5 38 2.56E-5
17 SGTC_1170 0310-0127 3.97 64.8 µM 2.67E-5 28 3.57E-5
18 SGTC_1958 st076513 3.94 41.9 µM 3.01E-5 60S ribosome export 29 4.02E-5
19 SGTC_791 1348-1292 3.93 225.0 µM 3.16E-5 36 4.21E-5
20 SGTC_1436 4092-1007 3.83 8.3 µM 4.77E-5 15 6.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.77E-10 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.101 4.52E-9 YML111W BUL2 hom Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication
0.099 1.05E-8 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.087 3.85E-7 YCL022C_d YCL022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
0.087 4.28E-7 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.082 1.92E-6 YNL072W RNH201 hom Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome
0.077 8.76E-6 YPL003W ULA1 hom Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
0.075 1.20E-5 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.075 1.48E-5 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.075 1.52E-5 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.073 2.41E-5 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.073 2.48E-5 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.073 2.57E-5 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.070 5.64E-5 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.069 5.75E-5 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA