HIPHOP chemogenomics database
YHR125W_d 
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR125W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.150 | 2.24E-18 | YJL150W_d | YJL150W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.108 | 4.07E-10 | YGR217W | CCH1 | hom | Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together |
| 0.105 | 9.26E-10 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
| 0.100 | 6.37E-9 | YOR071C | NRT1 | hom | High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity |
| 0.093 | 6.49E-8 | YBR108W | AIM3 | hom | Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
| 0.092 | 8.63E-8 | YMR118C_p | SHH3_p | hom | Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase |
| 0.090 | 1.79E-7 | YJR099W | YUH1 | hom | Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p |
| 0.089 | 2.43E-7 | YEL008W_d | YEL008W_d | hom | Hypothetical protein predicted to be involved in metabolism |
| 0.081 | 2.98E-6 | YDL187C_d | YDL187C_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.080 | 3.44E-6 | YJL136W-A_p | YJL136W-A_p | hom | Putative protein of unknown function; identified by SAGE |
| 0.080 | 3.37E-6 | YOL045W | PSK2 | hom | PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication |
| 0.080 | 3.47E-6 | YER093C | TSC11 | het | Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain |
| 0.080 | 3.52E-6 | YOR015W_d | YOR015W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.080 | 3.88E-6 | YBR156C | SLI15 | hom | Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly |
| 0.077 | 7.30E-6 | YIL118W | RHO3 | het | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p |