YHR125W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR125W / YHR125W

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:7.01|P-value:1.89E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:4.07|P-value:6.11E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.34|P-value:8.39E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.43|P-value:6.23E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.95|P-value:9.62E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:5.21|P-value:4.39E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:3.51|P-value:4.54E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.46|P-value:1.26E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:4.62|P-value:6.56E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.63|P-value:3.04E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.47|P-value:1.25E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.28|P-value:2.66E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:4.73|P-value:4.02E-6 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.34|P-value:8.10E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.07|P-value:6.13E-5 ID:SGTC_1697|Compound:st025554|FD-Score:5.18|P-value:5.10E-7 ID:SGTC_1702|Compound:st027038|FD-Score:4.61|P-value:6.90E-6 ID:SGTC_1767|Compound:st044992|FD-Score:4.31|P-value:2.32E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.87|P-value:1.27E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.58|P-value:3.63E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.32|P-value:8.62E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.42|P-value:6.18E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-3.41|P-value:6.77E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.37|P-value:7.33E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.31|P-value:2.34E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.93|P-value:1.63E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.49|P-value:4.87E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.78|P-value:1.79E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.85|P-value:1.41E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.72|P-value:2.23E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.98|P-value:1.29E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.17|P-value:4.41E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.82|P-value:2.68E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.08|P-value:5.90E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.01|P-value:7.98E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.34|P-value:2.08E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.24|P-value:3.37E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.53|P-value:4.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.71|P-value:2.33E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.67|P-value:2.64E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.51|P-value:4.75E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.20|P-value:3.69E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.54|P-value:4.20E-4 ID:SGTC_3279|Compound:9140807|FD-Score:5.63|P-value:5.52E-8 ID:SGTC_3291|Compound:9121177|FD-Score:5.76|P-value:2.70E-8 ID:SGTC_65|Compound:0798-0905|FD-Score:7.01|P-value:1.89E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:4.07|P-value:6.11E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.34|P-value:8.39E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.43|P-value:6.23E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.95|P-value:9.62E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:5.21|P-value:4.39E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:3.51|P-value:4.54E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.46|P-value:1.26E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:4.62|P-value:6.56E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.63|P-value:3.04E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.47|P-value:1.25E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.28|P-value:2.66E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:4.73|P-value:4.02E-6 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.34|P-value:8.10E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.07|P-value:6.13E-5 ID:SGTC_1697|Compound:st025554|FD-Score:5.18|P-value:5.10E-7 ID:SGTC_1702|Compound:st027038|FD-Score:4.61|P-value:6.90E-6 ID:SGTC_1767|Compound:st044992|FD-Score:4.31|P-value:2.32E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.87|P-value:1.27E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.58|P-value:3.63E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.32|P-value:8.62E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.42|P-value:6.18E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-3.41|P-value:6.77E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.37|P-value:7.33E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.31|P-value:2.34E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.93|P-value:1.63E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.49|P-value:4.87E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.78|P-value:1.79E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.85|P-value:1.41E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.72|P-value:2.23E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.98|P-value:1.29E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.17|P-value:4.41E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.82|P-value:2.68E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.08|P-value:5.90E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.01|P-value:7.98E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.34|P-value:2.08E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.24|P-value:3.37E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.53|P-value:4.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.71|P-value:2.33E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.67|P-value:2.64E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.51|P-value:4.75E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.20|P-value:3.69E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.54|P-value:4.20E-4 ID:SGTC_3279|Compound:9140807|FD-Score:5.63|P-value:5.52E-8 ID:SGTC_3291|Compound:9121177|FD-Score:5.76|P-value:2.70E-8

Top fitness defect scores for YHR125W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 7.01 35.0 µM 1.89E-11 calcium & mitochondrial duress 20 1.20E-12
2 SGTC_3291 9121177 5.76 71.4 µM 2.70E-8 2 4.15E-9
3 SGTC_3279 9140807 5.63 49.5 µM 5.52E-8 6 9.25E-9
4 SGTC_570 0987-0065 5.21 62.6 µM 4.39E-7 60S ribosome export 3 9.43E-8
5 SGTC_1697 st025554 5.18 27.7 µM 5.10E-7 14 1.12E-7
6 SGTC_2587 piperic acid 4.98 92.2 µM 1.29E-6 6 3.15E-7
7 SGTC_2274 7947094 4.93 46.1 µM 1.63E-6 10 4.09E-7
8 SGTC_2635 hydroquinidine 4.82 100.0 µM 2.68E-6 8 7.14E-7
9 SGTC_1286 0929-0070 4.73 131.0 µM 4.02E-6 11 1.13E-6
10 SGTC_838 0109-0203 4.62 71.4 µM 6.56E-6 7 1.95E-6
11 SGTC_1702 st027038 4.61 51.0 µM 6.90E-6 4 2.06E-6
12 SGTC_1129 3453-1384 4.47 223.0 µM 1.25E-5 27 4.00E-6
13 SGTC_670 4204-0025 4.46 119.0 µM 1.26E-5 copper-dependent oxidative stress 21 4.03E-6
14 SGTC_2649 anisomycin 4.34 9.6 µM 2.08E-5 6 7.09E-6
15 SGTC_1767 st044992 4.31 70.3 µM 2.32E-5 14 8.00E-6
16 SGTC_2249 haloperidol 4.31 116.4 µM 2.34E-5 ergosterol depletion effects on membrane 89 8.07E-6
17 SGTC_1267 0828-0272 4.28 9.5 µM 2.66E-5 15 9.34E-6
18 SGTC_2850 9015429 4.20 58.4 µM 3.69E-5 8 1.35E-5
19 SGTC_2636 apigenin dimethyl ether 4.08 100.0 µM 5.90E-5 43 2.27E-5
20 SGTC_86 0417-1630 4.07 471.9 µM 6.11E-5 ubiquinone biosynthesis & proteasome 144 2.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.24E-18 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 4.07E-10 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.105 9.26E-10 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.100 6.37E-9 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.093 6.49E-8 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.092 8.63E-8 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.090 1.79E-7 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.089 2.43E-7 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.081 2.98E-6 YDL187C_d YDL187C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.44E-6 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.080 3.37E-6 YOL045W PSK2 hom PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication
0.080 3.47E-6 YER093C TSC11 het Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
0.080 3.52E-6 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.88E-6 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.077 7.30E-6 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p