YHR126C_p / ANS1

Putative GPI protein; transcription dependent upon Azf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR126C / ANS1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.43|P-value:2.45E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.22|P-value:5.37E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.29|P-value:4.14E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.73|P-value:7.46E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.21|P-value:5.62E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.61|P-value:1.15E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.82|P-value:4.96E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:4.47|P-value:2.79E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.38|P-value:2.81E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.21|P-value:5.64E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:5.07|P-value:1.29E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.34|P-value:5.21E-6 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.92|P-value:2.85E-7 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.24|P-value:5.03E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.12|P-value:7.66E-4 ID:SGTC_1632|Compound:st005650|FD-Score:5.06|P-value:1.38E-7 ID:SGTC_1720|Compound:st037298|FD-Score:3.65|P-value:1.07E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.11|P-value:8.11E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.32|P-value:3.76E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.33|P-value:5.39E-6 ID:SGTC_2256|Compound:7954252|FD-Score:4.02|P-value:2.23E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.69|P-value:8.19E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.06|P-value:1.91E-5 ID:SGTC_2383|Compound:9036125|FD-Score:4.41|P-value:3.72E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.85|P-value:4.60E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.55|P-value:1.91E-6 ID:SGTC_2783|Compound:7738165|FD-Score:-3.24|P-value:4.73E-4 ID:SGTC_2820|Compound:7989630|FD-Score:-3.34|P-value:3.26E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.83|P-value:4.93E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.47|P-value:1.97E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.07|P-value:9.19E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.10|P-value:7.84E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.17|P-value:6.38E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.43|P-value:2.45E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.22|P-value:5.37E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.29|P-value:4.14E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.73|P-value:7.46E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.21|P-value:5.62E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.61|P-value:1.15E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.82|P-value:4.96E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:4.47|P-value:2.79E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.38|P-value:2.81E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.21|P-value:5.64E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:5.07|P-value:1.29E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.34|P-value:5.21E-6 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.92|P-value:2.85E-7 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.24|P-value:5.03E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.12|P-value:7.66E-4 ID:SGTC_1632|Compound:st005650|FD-Score:5.06|P-value:1.38E-7 ID:SGTC_1720|Compound:st037298|FD-Score:3.65|P-value:1.07E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.11|P-value:8.11E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.32|P-value:3.76E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.33|P-value:5.39E-6 ID:SGTC_2256|Compound:7954252|FD-Score:4.02|P-value:2.23E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.69|P-value:8.19E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.06|P-value:1.91E-5 ID:SGTC_2383|Compound:9036125|FD-Score:4.41|P-value:3.72E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.85|P-value:4.60E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.55|P-value:1.91E-6 ID:SGTC_2783|Compound:7738165|FD-Score:-3.24|P-value:4.73E-4 ID:SGTC_2820|Compound:7989630|FD-Score:-3.34|P-value:3.26E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.83|P-value:4.93E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.47|P-value:1.97E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.07|P-value:9.19E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.10|P-value:7.84E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.17|P-value:6.38E-4

Top fitness defect scores for YHR126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1302 1159-0335 5.07 255.0 µM 1.29E-7 3 1.97E-7
2 SGTC_1632 st005650 5.06 90.0 µM 1.38E-7 9 2.12E-7
3 SGTC_1437 4092-1038 4.92 11.6 µM 2.85E-7 6 4.26E-7
4 SGTC_2572 astragaloside iv 4.55 100.0 µM 1.91E-6 13 2.69E-6
5 SGTC_774 k060-0086 4.47 136.0 µM 2.79E-6 10 3.88E-6
6 SGTC_2383 9036125 4.41 200.0 µM 3.72E-6 4 5.14E-6
7 SGTC_1367 1812-0510 4.34 76.9 µM 5.21E-6 13 7.12E-6
8 SGTC_1896 st058441 4.33 89.0 µM 5.39E-6 8 7.35E-6
9 SGTC_2314 7727897 4.06 200.0 µM 1.91E-5 20 2.50E-5
10 SGTC_2256 7954252 4.02 200.0 µM 2.23E-5 mitochondrial processes 6 2.91E-5
11 SGTC_2529 gangaleoidin 3.85 93.6 µM 4.60E-5 19 5.87E-5
12 SGTC_2826 7992541 3.83 19.5 µM 4.93E-5 21 6.28E-5
13 SGTC_165 k038-0023 3.73 64.4 µM 7.46E-5 ubiquinone biosynthesis & proteasome 91 9.39E-5
14 SGTC_1720 st037298 3.65 9.5 µM 1.07E-4 41 1.33E-4
15 SGTC_25 0118-0223 3.43 35.7 µM 2.45E-4 32 2.97E-4
16 SGTC_1763 st044482 3.32 94.5 µM 3.76E-4 copper-dependent oxidative stress 35 4.50E-4
17 SGTC_73 0327-0325 3.29 16.2 µM 4.14E-4 DNA damage response 79 4.95E-4
18 SGTC_1492 4158-0558 3.24 28.5 µM 5.03E-4 60S ribosome export 31 5.97E-4
19 SGTC_69 0096-0274 3.22 206.7 µM 5.37E-4 mitochondrial processes 84 6.36E-4
20 SGTC_474 dl-dihydrosphingosine 3.21 5.0 µM 5.62E-4 67 6.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 1.07E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.097 1.91E-8 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.091 1.48E-7 YDL168W SFA1 hom Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress
0.089 2.17E-7 YLR341W SPO77 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.088 3.64E-7 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.087 4.44E-7 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.084 1.11E-6 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.28E-6 YML063W RPS1B hom Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication
0.083 1.41E-6 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.081 2.54E-6 YCR010C ADY2 hom Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication
0.081 2.66E-6 YBL069W AST1 hom Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication
0.080 3.27E-6 YNL063W MTQ1 hom S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
0.078 6.03E-6 YOR118W RTC5 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
0.076 9.21E-6 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.073 2.23E-5 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor