YHR129C / ARP1

Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR129C / ARP1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:3.21|P-value:2.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.64|P-value:2.04E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:3.74|P-value:2.23E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:11.90|P-value:2.94E-39 ID:SGTC_160|Compound:3453-0671|FD-Score:5.34|P-value:2.63E-9 ID:SGTC_290|Compound:2043-6722|FD-Score:3.24|P-value:2.04E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.61|P-value:2.31E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.50|P-value:6.78E-5 ID:SGTC_446|Compound:go6976|FD-Score:2.98|P-value:5.80E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.83|P-value:6.51E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.91|P-value:4.00E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.85|P-value:3.82E-8 ID:SGTC_456|Compound:gingerol|FD-Score:3.20|P-value:2.40E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.20|P-value:2.41E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:2.98|P-value:5.90E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.23|P-value:2.19E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.10|P-value:3.75E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:4.80|P-value:7.74E-8 ID:SGTC_648|Compound:0375-0473|FD-Score:3.48|P-value:7.45E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.47|P-value:7.77E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.75|P-value:2.14E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.83|P-value:7.94E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:2.86|P-value:9.13E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.91|P-value:9.64E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.92|P-value:9.47E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.17|P-value:2.72E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.02|P-value:4.95E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.06|P-value:4.62E-6 ID:SGTC_1196|Compound:1588-0294|FD-Score:2.90|P-value:7.95E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.48|P-value:7.42E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.11|P-value:3.59E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.69|P-value:2.85E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.66|P-value:3.31E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.13|P-value:3.24E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.13|P-value:3.25E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:6.42|P-value:1.02E-12 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.55|P-value:5.43E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.19|P-value:2.38E-6 ID:SGTC_1605|Compound:st000082|FD-Score:3.43|P-value:9.19E-5 ID:SGTC_1615|Compound:st002656|FD-Score:3.22|P-value:2.28E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.02|P-value:5.80E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.43|P-value:9.01E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.17|P-value:2.11E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.56|P-value:3.18E-7 ID:SGTC_1801|Compound:st050089|FD-Score:2.93|P-value:7.21E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.04|P-value:5.10E-6 ID:SGTC_1863|Compound:st057641|FD-Score:4.37|P-value:9.11E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.09|P-value:3.89E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.48|P-value:7.22E-5 ID:SGTC_1898|Compound:st060199|FD-Score:5.14|P-value:9.22E-9 ID:SGTC_1924|Compound:st058459|FD-Score:2.91|P-value:7.66E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.96|P-value:2.95E-8 ID:SGTC_1937|Compound:st074714|FD-Score:4.82|P-value:6.84E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.04|P-value:4.70E-4 ID:SGTC_2172|Compound:5754775|FD-Score:4.16|P-value:2.69E-6 ID:SGTC_2223|Compound:6903751|FD-Score:3.82|P-value:1.56E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.02|P-value:4.94E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.38|P-value:1.12E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.85|P-value:9.51E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:2.84|P-value:9.90E-4 ID:SGTC_2517|Compound:totarol|FD-Score:7.10|P-value:3.68E-15 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.41|P-value:1.02E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.12|P-value:1.07E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.92|P-value:7.50E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.57|P-value:4.96E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.27|P-value:1.80E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.90|P-value:1.04E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.46|P-value:5.35E-7 ID:SGTC_2792|Compound:7535235|FD-Score:3.59|P-value:4.42E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.36|P-value:9.58E-7 ID:SGTC_2971|Compound:9092186|FD-Score:3.13|P-value:3.31E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.95|P-value:6.54E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.74|P-value:2.24E-5 ID:SGTC_3121|Compound:9125696|FD-Score:3.25|P-value:2.00E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.63|P-value:3.71E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.49|P-value:7.08E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.97|P-value:7.27E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.39|P-value:1.08E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.47|P-value:7.64E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:3.21|P-value:2.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.64|P-value:2.04E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:3.74|P-value:2.23E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:11.90|P-value:2.94E-39 ID:SGTC_160|Compound:3453-0671|FD-Score:5.34|P-value:2.63E-9 ID:SGTC_290|Compound:2043-6722|FD-Score:3.24|P-value:2.04E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.61|P-value:2.31E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.50|P-value:6.78E-5 ID:SGTC_446|Compound:go6976|FD-Score:2.98|P-value:5.80E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.83|P-value:6.51E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.91|P-value:4.00E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.85|P-value:3.82E-8 ID:SGTC_456|Compound:gingerol|FD-Score:3.20|P-value:2.40E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.20|P-value:2.41E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:2.98|P-value:5.90E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.23|P-value:2.19E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.10|P-value:3.75E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:4.80|P-value:7.74E-8 ID:SGTC_648|Compound:0375-0473|FD-Score:3.48|P-value:7.45E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.47|P-value:7.77E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.75|P-value:2.14E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.83|P-value:7.94E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:2.86|P-value:9.13E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.91|P-value:9.64E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.92|P-value:9.47E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.17|P-value:2.72E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.02|P-value:4.95E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.06|P-value:4.62E-6 ID:SGTC_1196|Compound:1588-0294|FD-Score:2.90|P-value:7.95E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.48|P-value:7.42E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.11|P-value:3.59E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.69|P-value:2.85E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.66|P-value:3.31E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.13|P-value:3.24E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.13|P-value:3.25E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:6.42|P-value:1.02E-12 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.55|P-value:5.43E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.19|P-value:2.38E-6 ID:SGTC_1605|Compound:st000082|FD-Score:3.43|P-value:9.19E-5 ID:SGTC_1615|Compound:st002656|FD-Score:3.22|P-value:2.28E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.02|P-value:5.80E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.43|P-value:9.01E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-3.17|P-value:2.11E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.56|P-value:3.18E-7 ID:SGTC_1801|Compound:st050089|FD-Score:2.93|P-value:7.21E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.04|P-value:5.10E-6 ID:SGTC_1863|Compound:st057641|FD-Score:4.37|P-value:9.11E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.09|P-value:3.89E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.48|P-value:7.22E-5 ID:SGTC_1898|Compound:st060199|FD-Score:5.14|P-value:9.22E-9 ID:SGTC_1924|Compound:st058459|FD-Score:2.91|P-value:7.66E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.96|P-value:2.95E-8 ID:SGTC_1937|Compound:st074714|FD-Score:4.82|P-value:6.84E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.04|P-value:4.70E-4 ID:SGTC_2172|Compound:5754775|FD-Score:4.16|P-value:2.69E-6 ID:SGTC_2223|Compound:6903751|FD-Score:3.82|P-value:1.56E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.02|P-value:4.94E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.38|P-value:1.12E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.85|P-value:9.51E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:2.84|P-value:9.90E-4 ID:SGTC_2517|Compound:totarol|FD-Score:7.10|P-value:3.68E-15 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.41|P-value:1.02E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:5.12|P-value:1.07E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.92|P-value:7.50E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.57|P-value:4.96E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.27|P-value:1.80E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.90|P-value:1.04E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.46|P-value:5.35E-7 ID:SGTC_2792|Compound:7535235|FD-Score:3.59|P-value:4.42E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.36|P-value:9.58E-7 ID:SGTC_2971|Compound:9092186|FD-Score:3.13|P-value:3.31E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.95|P-value:6.54E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.74|P-value:2.24E-5 ID:SGTC_3121|Compound:9125696|FD-Score:3.25|P-value:2.00E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.63|P-value:3.71E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.49|P-value:7.08E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.97|P-value:7.27E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.39|P-value:1.08E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.47|P-value:7.64E-5

Top fitness defect scores for YHR129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 11.90 40.9 µM 2.94E-39 cell wall 29 6.88E-33
2 SGTC_2517 totarol 7.10 10.0 µM 3.68E-15 1 6.44E-13
3 SGTC_1533 dihydroergotamine mesylate 6.42 29.4 µM 1.02E-12 DNA intercalators 1 6.89E-11
4 SGTC_160 3453-0671 5.34 289.7 µM 2.63E-9 16 4.77E-8
5 SGTC_1898 st060199 5.14 18.6 µM 9.22E-9 2 1.36E-7
6 SGTC_2560 caryophyllene 5.12 100.0 µM 1.07E-8 5 1.54E-7
7 SGTC_1936 st074407 4.96 74.3 µM 2.95E-8 DNA damage response 13 3.58E-7
8 SGTC_453 enantio-paf c16 4.91 10.0 µM 4.00E-8 91 4.62E-7
9 SGTC_450 aminopyrene 4.83 156.0 nM 6.51E-8 18 6.95E-7
10 SGTC_1937 st074714 4.82 47.2 µM 6.84E-8 24 7.24E-7
11 SGTC_572 0960-0087 4.80 17.7 µM 7.74E-8 11 8.03E-7
12 SGTC_304 1310-0298 4.61 97.0 µM 2.31E-7 cell wall 36 2.00E-6
13 SGTC_1720 st037298 4.56 9.5 µM 3.18E-7 27 2.61E-6
14 SGTC_2787 5284540 4.46 71.4 µM 5.35E-7 15 4.03E-6
15 SGTC_1863 st057641 4.37 20.1 µM 9.11E-7 7 6.30E-6
16 SGTC_2800 7887935 4.36 81.8 µM 9.58E-7 RPP1 & pyrimidine depletion 18 6.57E-6
17 SGTC_1574 spiramycin 4.19 23.7 µM 2.38E-6 21 1.41E-5
18 SGTC_2172 5754775 4.16 163.9 µM 2.69E-6 12 1.56E-5
19 SGTC_1359 1582-0056 4.13 520.0 nM 3.24E-6 17 1.82E-5
20 SGTC_514 4466-0038 4.10 2.6 nM 3.75E-6 cell wall 143 2.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.272 3.96E-58 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.251 1.80E-49 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.250 4.30E-49 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.246 2.67E-47 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.245 5.59E-47 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.245 5.85E-47 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.243 3.45E-46 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.239 1.20E-44 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.233 1.49E-42 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.229 2.69E-41 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.229 4.97E-41 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.226 5.74E-40 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.225 8.24E-40 YMR294W JNM1 hom Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
0.222 9.76E-39 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.220 6.58E-38 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization