YHR131C_p

Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR131C / YHR131C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:2.79|P-value:7.89E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.72|P-value:9.69E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.92|P-value:4.73E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.09|P-value:2.22E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.92|P-value:4.79E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.77|P-value:8.43E-15 ID:SGTC_363|Compound:0455-0021|FD-Score:3.20|P-value:1.42E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.08|P-value:2.42E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.51|P-value:3.33E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.09|P-value:2.31E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.26|P-value:7.05E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:3.85|P-value:6.59E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.04|P-value:2.32E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.09|P-value:2.23E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.31|P-value:8.40E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.00|P-value:3.47E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.00|P-value:3.34E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.08|P-value:2.46E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.91|P-value:5.01E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.62|P-value:1.89E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.15|P-value:1.71E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.38|P-value:6.32E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-2.95|P-value:3.98E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.98|P-value:3.73E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.26|P-value:1.06E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.10|P-value:2.23E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.76|P-value:1.00E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.91|P-value:4.80E-6 ID:SGTC_1908|Compound:st060353|FD-Score:5.68|P-value:6.11E-11 ID:SGTC_1910|Compound:st062352|FD-Score:-5.79|P-value:2.34E-11 ID:SGTC_1915|Compound:st067105|FD-Score:-5.52|P-value:1.80E-10 ID:SGTC_2013|Compound:4024628|FD-Score:2.81|P-value:7.38E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.09|P-value:2.33E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.76|P-value:8.56E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.03|P-value:3.01E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.78|P-value:8.60E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.24|P-value:1.16E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.86|P-value:5.99E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.43|P-value:2.34E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.74|P-value:9.08E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.62|P-value:1.94E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.98|P-value:3.32E-6 ID:SGTC_2462|Compound:5162487|FD-Score:2.82|P-value:7.01E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.29|P-value:9.01E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-4.51|P-value:1.46E-7 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.16|P-value:1.76E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.93|P-value:4.45E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.76|P-value:8.77E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.74|P-value:8.97E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.29|P-value:9.66E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.22|P-value:1.23E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:2.79|P-value:7.89E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.72|P-value:9.69E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.92|P-value:4.73E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.09|P-value:2.22E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.92|P-value:4.79E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.77|P-value:8.43E-15 ID:SGTC_363|Compound:0455-0021|FD-Score:3.20|P-value:1.42E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.08|P-value:2.42E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.51|P-value:3.33E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.09|P-value:2.31E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.26|P-value:7.05E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:3.85|P-value:6.59E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.04|P-value:2.32E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.09|P-value:2.23E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.31|P-value:8.40E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.00|P-value:3.47E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.00|P-value:3.34E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.08|P-value:2.46E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.91|P-value:5.01E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.62|P-value:1.89E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.15|P-value:1.71E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.38|P-value:6.32E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-2.95|P-value:3.98E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.98|P-value:3.73E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.26|P-value:1.06E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.10|P-value:2.23E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.76|P-value:1.00E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.91|P-value:4.80E-6 ID:SGTC_1908|Compound:st060353|FD-Score:5.68|P-value:6.11E-11 ID:SGTC_1910|Compound:st062352|FD-Score:-5.79|P-value:2.34E-11 ID:SGTC_1915|Compound:st067105|FD-Score:-5.52|P-value:1.80E-10 ID:SGTC_2013|Compound:4024628|FD-Score:2.81|P-value:7.38E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.09|P-value:2.33E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.76|P-value:8.56E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.03|P-value:3.01E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.78|P-value:8.60E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.24|P-value:1.16E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.86|P-value:5.99E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.43|P-value:2.34E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.74|P-value:9.08E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.62|P-value:1.94E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.98|P-value:3.32E-6 ID:SGTC_2462|Compound:5162487|FD-Score:2.82|P-value:7.01E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.29|P-value:9.01E-5 ID:SGTC_2486|Compound:5283202|FD-Score:-4.51|P-value:1.46E-7 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.16|P-value:1.76E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.93|P-value:4.45E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.76|P-value:8.77E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.74|P-value:8.97E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.29|P-value:9.66E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.22|P-value:1.23E-4

Top fitness defect scores for YHR131C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 6.77 9.4 µM 8.43E-15 12 6.58E-12
2 SGTC_1908 st060353 5.68 56.5 µM 6.11E-11 RPP1 & pyrimidine depletion 10 6.81E-9
3 SGTC_716 1683-5115 4.26 658.0 µM 7.05E-7 14 1.04E-5
4 SGTC_988 1497-1057 4.04 103.0 µM 2.32E-6 9 2.64E-5
5 SGTC_2435 5706476 3.98 10.6 µM 3.32E-6 25 3.50E-5
6 SGTC_1758 st042942 3.91 75.2 µM 4.80E-6 24 4.69E-5
7 SGTC_987 1497-1013 3.85 404.0 µM 6.59E-6 13 6.01E-5
8 SGTC_1751 st044839 3.76 27.2 µM 1.00E-5 Golgi 13 8.36E-5
9 SGTC_1304 1165-0502 3.38 251.0 µM 6.32E-5 88 3.57E-4
10 SGTC_2876 9059903 3.29 26.0 µM 9.66E-5 30 4.99E-4
11 SGTC_363 0455-0021 3.20 3.1 µM 1.42E-4 azole & statin 108 6.77E-4
12 SGTC_2490 carminic acid 3.16 95.4 µM 1.76E-4 18 8.01E-4
13 SGTC_1749 st037932 3.10 54.2 µM 2.23E-4 59 9.67E-4
14 SGTC_633 0437-0093 3.09 97.7 µM 2.31E-4 DNA intercalators 43 9.95E-4
15 SGTC_2014 4013930 3.09 200.0 µM 2.33E-4 78 0.00100
16 SGTC_509 pifithrin 3.08 175.0 µM 2.42E-4 mitochondrial processes 22 0.00103
17 SGTC_1263 0774-1208 3.08 64.8 µM 2.46E-4 107 0.00104
18 SGTC_2182 6325192 3.03 200.0 µM 3.01E-4 Golgi 37 0.00122
19 SGTC_1230 0170-0365 3.00 3.8 µM 3.34E-4 endomembrane recycling 135 0.00133
20 SGTC_1119 parthenolide 3.00 318.5 nM 3.47E-4 TSC3-RPN4 97 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.67E-25 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.168 1.79E-22 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.150 2.38E-18 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.149 3.54E-18 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.146 1.77E-17 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.145 3.92E-17 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.144 6.59E-17 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.143 1.00E-16 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.143 1.06E-16 YIL116W HIS5 hom Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.142 1.49E-16 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.140 4.20E-16 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.139 5.34E-16 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.127 1.72E-13 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.125 3.64E-13 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.123 8.48E-13 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins