YHR132C / ECM14

Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR132C / ECM14

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:-3.19|P-value:9.51E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.40|P-value:3.82E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.96|P-value:4.94E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.26|P-value:7.31E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:8.25E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.56|P-value:2.16E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.38|P-value:5.63E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:3.13|P-value:9.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.48|P-value:2.87E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.14|P-value:2.14E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.68|P-value:1.90E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.88|P-value:6.40E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.30|P-value:5.56E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.27|P-value:6.02E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.94|P-value:4.95E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.48|P-value:2.87E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.46|P-value:3.67E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.23|P-value:1.46E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-4.99|P-value:5.42E-7 ID:SGTC_2076|Compound:5212012|FD-Score:3.46|P-value:3.07E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.50|P-value:3.19E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-3.18|P-value:9.53E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.64|P-value:1.89E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.84|P-value:7.24E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.61|P-value:1.78E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.14|P-value:9.56E-4 ID:SGTC_2432|Compound:5630864|FD-Score:5.94|P-value:2.29E-9 ID:SGTC_2436|Compound:5633522|FD-Score:4.64|P-value:2.27E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.47|P-value:5.01E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.57|P-value:2.46E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.70|P-value:1.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.41|P-value:3.74E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.17|P-value:8.61E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.63|P-value:1.99E-4 ID:SGTC_2887|Compound:9044784|FD-Score:6.38|P-value:1.55E-10 ID:SGTC_2897|Compound:9048598|FD-Score:3.68|P-value:1.39E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.59|P-value:1.96E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.65|P-value:1.87E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.51|P-value:4.21E-6 ID:SGTC_3175|Compound:9106517|FD-Score:3.52|P-value:2.51E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.19|P-value:7.98E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.13|P-value:9.62E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.40|P-value:3.91E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.19|P-value:7.99E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.19|P-value:9.51E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.40|P-value:3.82E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.96|P-value:4.94E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.26|P-value:7.31E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:8.25E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.56|P-value:2.16E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.38|P-value:5.63E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:3.13|P-value:9.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.48|P-value:2.87E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.14|P-value:2.14E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.68|P-value:1.90E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.88|P-value:6.40E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.30|P-value:5.56E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.27|P-value:6.02E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.94|P-value:4.95E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.48|P-value:2.87E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.46|P-value:3.67E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.23|P-value:1.46E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-4.99|P-value:5.42E-7 ID:SGTC_2076|Compound:5212012|FD-Score:3.46|P-value:3.07E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.50|P-value:3.19E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-3.18|P-value:9.53E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.64|P-value:1.89E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.84|P-value:7.24E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.61|P-value:1.78E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.14|P-value:9.56E-4 ID:SGTC_2432|Compound:5630864|FD-Score:5.94|P-value:2.29E-9 ID:SGTC_2436|Compound:5633522|FD-Score:4.64|P-value:2.27E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.47|P-value:5.01E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.57|P-value:2.46E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.70|P-value:1.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.41|P-value:3.74E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.17|P-value:8.61E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.63|P-value:1.99E-4 ID:SGTC_2887|Compound:9044784|FD-Score:6.38|P-value:1.55E-10 ID:SGTC_2897|Compound:9048598|FD-Score:3.68|P-value:1.39E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.59|P-value:1.96E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.65|P-value:1.87E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.51|P-value:4.21E-6 ID:SGTC_3175|Compound:9106517|FD-Score:3.52|P-value:2.51E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.19|P-value:7.98E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.13|P-value:9.62E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.40|P-value:3.91E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.19|P-value:7.99E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.67|P-value:1.46E-4

Top fitness defect scores for YHR132C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2887 9044784 6.38 58.4 µM 1.55E-10 fatty acid desaturase (OLE1) 7 8.60E-11
2 SGTC_2432 5630864 5.94 12.2 µM 2.29E-9 3 1.39E-9
3 SGTC_831 k061-1017 5.38 217.0 µM 5.63E-8 translation 16 3.78E-8
4 SGTC_126 0417-1624 4.96 672.5 µM 4.94E-7 DNA intercalators 7 3.54E-7
5 SGTC_1199 1638-0010 4.68 4.5 µM 1.90E-6 endomembrane recycling 8 1.42E-6
6 SGTC_2436 5633522 4.64 8.1 µM 2.27E-6 9 1.71E-6
7 SGTC_3141 9094609 4.51 49.5 µM 4.21E-6 iron homeostasis 25 3.22E-6
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.47 3.7 µM 5.01E-6 54 3.85E-6
9 SGTC_1605 st000082 4.23 49.1 µM 1.46E-5 60S ribosome export 10 1.16E-5
10 SGTC_1197 1601-0112 4.14 267.0 µM 2.14E-5 16 1.72E-5
11 SGTC_1427 4048-4900 3.94 550.0 nM 4.95E-5 26 4.08E-5
12 SGTC_1218 1348-1416 3.88 30.7 µM 6.40E-5 SWF1 & branched chain AA biosynthesis 16 5.31E-5
13 SGTC_2345 9052315 3.84 157.4 µM 7.24E-5 21 6.03E-5
14 SGTC_1554 st069299 3.70 38.7 µM 1.26E-4 30 1.06E-4
15 SGTC_2897 9048598 3.68 13.0 µM 1.39E-4 21 1.18E-4
16 SGTC_3353 9151644 3.67 39.3 µM 1.46E-4 19 1.24E-4
17 SGTC_2777 climbazole 3.65 1.5 µM 1.53E-4 iron homeostasis 65 1.31E-4
18 SGTC_2346 9031566 3.61 143.8 µM 1.78E-4 Golgi 34 1.52E-4
19 SGTC_2954 9074818 3.59 52.7 µM 1.96E-4 49 1.68E-4
20 SGTC_1331 1472-0049 3.57 76.2 µM 2.06E-4 32 1.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.89E-10 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.093 7.04E-8 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.091 1.30E-7 YNR073C_p YNR073C_p hom Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
0.087 5.13E-7 YKL112W ABF1 het DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
0.083 1.35E-6 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.082 1.92E-6 YDL085C-A_p YDL085C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.079 4.99E-6 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.078 5.91E-6 YPR019W MCM4 het Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
0.077 7.57E-6 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.076 1.13E-5 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.36E-5 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.072 3.35E-5 YCL057W PRD1 hom Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress
0.071 3.93E-5 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.071 4.21E-5 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.070 5.42E-5 YHR178W STB5 hom Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro