YHR132W-A / IGO2

Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR132W-A / IGO2

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.82|P-value:1.12E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.55|P-value:4.15E-8 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.51|P-value:3.50E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.50|P-value:3.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.69|P-value:1.85E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.60|P-value:2.55E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.56|P-value:2.93E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.57|P-value:2.84E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.76|P-value:1.42E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.54|P-value:3.09E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.57|P-value:2.79E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.52|P-value:3.28E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.27|P-value:7.88E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.67|P-value:1.92E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-4.00|P-value:5.69E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.28|P-value:7.57E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.83|P-value:1.05E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.40|P-value:5.24E-4 ID:SGTC_2139|Compound:5578692|FD-Score:5.86|P-value:7.32E-9 ID:SGTC_2145|Compound:5634607|FD-Score:-3.97|P-value:6.27E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-5.91|P-value:5.94E-9 ID:SGTC_2303|Compound:7774051|FD-Score:5.50|P-value:5.23E-8 ID:SGTC_2423|Compound:st077119|FD-Score:-3.87|P-value:9.37E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.59|P-value:2.63E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.94|P-value:7.08E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.90|P-value:1.30E-11 ID:SGTC_2602|Compound:kawain|FD-Score:3.28|P-value:7.61E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.33|P-value:1.46E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-6.08|P-value:2.14E-9 ID:SGTC_2785|Compound:7756463|FD-Score:-3.55|P-value:3.04E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-5.12|P-value:3.81E-7 ID:SGTC_2789|Compound:5281112|FD-Score:-3.69|P-value:1.85E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-8.51|P-value:1.06E-16 ID:SGTC_2808|Compound:7946468|FD-Score:-6.03|P-value:2.99E-9 ID:SGTC_2809|Compound:7964133|FD-Score:4.21|P-value:2.31E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-4.78|P-value:2.01E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.82|P-value:1.12E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.55|P-value:4.15E-8 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.51|P-value:3.50E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.50|P-value:3.63E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.69|P-value:1.85E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.60|P-value:2.55E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.56|P-value:2.93E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.57|P-value:2.84E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.76|P-value:1.42E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.54|P-value:3.09E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.57|P-value:2.79E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.52|P-value:3.28E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.27|P-value:7.88E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.67|P-value:1.92E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-4.00|P-value:5.69E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.28|P-value:7.57E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.83|P-value:1.05E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.40|P-value:5.24E-4 ID:SGTC_2139|Compound:5578692|FD-Score:5.86|P-value:7.32E-9 ID:SGTC_2145|Compound:5634607|FD-Score:-3.97|P-value:6.27E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-5.91|P-value:5.94E-9 ID:SGTC_2303|Compound:7774051|FD-Score:5.50|P-value:5.23E-8 ID:SGTC_2423|Compound:st077119|FD-Score:-3.87|P-value:9.37E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.59|P-value:2.63E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.94|P-value:7.08E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.90|P-value:1.30E-11 ID:SGTC_2602|Compound:kawain|FD-Score:3.28|P-value:7.61E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.33|P-value:1.46E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-6.08|P-value:2.14E-9 ID:SGTC_2785|Compound:7756463|FD-Score:-3.55|P-value:3.04E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-5.12|P-value:3.81E-7 ID:SGTC_2789|Compound:5281112|FD-Score:-3.69|P-value:1.85E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-8.51|P-value:1.06E-16 ID:SGTC_2808|Compound:7946468|FD-Score:-6.03|P-value:2.99E-9 ID:SGTC_2809|Compound:7964133|FD-Score:4.21|P-value:2.31E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-4.78|P-value:2.01E-6

Top fitness defect scores for YHR132W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 6.90 100.0 µM 1.30E-11 3 2.63E-12
2 SGTC_2139 5578692 5.86 56.5 µM 7.32E-9 superoxide 4 2.29E-9
3 SGTC_163 1327-0036 5.55 7.5 µM 4.15E-8 56 1.46E-8
4 SGTC_2303 7774051 5.50 200.0 µM 5.23E-8 6 1.87E-8
5 SGTC_2809 7964133 4.21 13.0 µM 2.31E-5 60S ribosome export 30 1.25E-5
6 SGTC_2518 prenyletin 3.94 46.3 µM 7.08E-5 11 4.14E-5
7 SGTC_2045 5106652 3.83 78.0 µM 1.05E-4 14 6.31E-5
8 SGTC_115 0527-0192 3.82 112.0 µM 1.12E-4 80 6.79E-5
9 SGTC_1678 st019265 3.67 80.2 µM 1.92E-4 60S ribosome export 31 1.20E-4
10 SGTC_1027 k015-0025 3.57 8.7 µM 2.79E-4 37 1.79E-4
11 SGTC_798 1287-0182 3.54 476.0 µM 3.09E-4 32 1.99E-4
12 SGTC_1370 2001-0092 3.52 44.6 µM 3.28E-4 51 2.13E-4
13 SGTC_359 0081-0058 3.50 15.9 µM 3.63E-4 60S ribosome export 64 2.37E-4
14 SGTC_1680 diphenhydramine 3.48 100.0 µM 3.82E-4 NEO1 45 2.50E-4
15 SGTC_1988 st071872 3.28 53.4 µM 7.57E-4 24 5.18E-4
16 SGTC_2602 kawain 3.28 100.0 µM 7.61E-4 55 5.22E-4
17 SGTC_1383 3049-0032 3.27 20.7 µM 7.88E-4 60S ribosome export 40 5.41E-4
18 SGTC_2627 acetyl isogambogic acid 3.19 100.0 µM 0.00103 TSC3-RPN4 77 7.21E-4
19 SGTC_2831 7999036 3.17 19.5 µM 0.00109 90 7.65E-4
20 SGTC_1186 1319-0216 3.12 26.0 µM 0.00128 52 9.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 2.16E-17 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.121 2.12E-12 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.119 5.32E-12 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.118 8.05E-12 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.116 1.88E-11 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.109 2.25E-10 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.104 1.32E-9 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.104 1.80E-9 YKR079C TRZ1 het tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
0.103 1.98E-9 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.100 6.51E-9 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.96E-8 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.096 2.86E-8 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.095 3.53E-8 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.095 3.52E-8 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.086 6.26E-7 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C