Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR133C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.085 | 9.26E-7 | YDR309C | GIC2 | hom | Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region |
0.083 | 1.29E-6 | YOR045W | TOM6 | hom | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex |
0.083 | 1.39E-6 | YBR138C_p | YBR138C_p | hom | Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene |
0.083 | 1.46E-6 | YDL160C-A | MHF2 | hom | Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 |
0.083 | 1.67E-6 | YKL187C | FAT3 | hom | Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies |
0.078 | 5.41E-6 | YKL162C_p | YKL162C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion |
0.078 | 6.26E-6 | YKL061W_p | BLI1_p | hom | Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome |
0.075 | 1.29E-5 | YPR055W | SEC8 | het | Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress |
0.074 | 1.59E-5 | YOR385W_p | YOR385W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene |
0.073 | 2.34E-5 | YPL273W | SAM4 | hom | S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio |
0.072 | 2.89E-5 | YPL156C | PRM4 | hom | Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift |
0.068 | 7.57E-5 | YPL073C_d | YPL073C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments |
0.068 | 8.19E-5 | YOR034C | AKR2 | hom | Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication |
0.067 | 1.12E-4 | YCR081W | SRB8 | hom | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression |
0.066 | 1.30E-4 | YPR076W_d | YPR076W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |