YHR134W / WSS1

Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR134W / WSS1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.97|P-value:5.91E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-8.55|P-value:1.01E-19 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.87|P-value:7.43E-11 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.03|P-value:9.54E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.51|P-value:5.13E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.03|P-value:3.78E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:6.37|P-value:1.87E-12 ID:SGTC_428|Compound:3448-4153|FD-Score:4.57|P-value:2.65E-7 ID:SGTC_446|Compound:go6976|FD-Score:3.11|P-value:2.75E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.43|P-value:5.65E-7 ID:SGTC_456|Compound:gingerol|FD-Score:4.61|P-value:2.07E-7 ID:SGTC_631|Compound:k072-0230|FD-Score:3.71|P-value:2.13E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.42|P-value:7.70E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:2.90|P-value:6.16E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.57|P-value:3.90E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.81|P-value:4.48E-13 ID:SGTC_763|Compound:3453-1109|FD-Score:3.59|P-value:3.56E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.18|P-value:5.44E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:2.80|P-value:8.91E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:4.43|P-value:5.72E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:2.81|P-value:8.46E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.78|P-value:9.43E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:2.86|P-value:7.01E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.79|P-value:1.47E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.63|P-value:3.03E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.08|P-value:3.05E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.94|P-value:5.22E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.83|P-value:7.89E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:2.96|P-value:4.89E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.83|P-value:8.10E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.00|P-value:4.23E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.07|P-value:3.72E-6 ID:SGTC_1530|Compound:rhein|FD-Score:3.31|P-value:1.22E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.82|P-value:8.29E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.19|P-value:1.97E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.35|P-value:2.81E-4 ID:SGTC_1949|Compound:st076024|FD-Score:2.91|P-value:6.01E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.71|P-value:1.18E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-3.56|P-value:1.19E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.10|P-value:2.88E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.79|P-value:1.45E-5 ID:SGTC_2206|Compound:7254556|FD-Score:3.32|P-value:1.18E-4 ID:SGTC_2216|Compound:7189485|FD-Score:-3.11|P-value:7.00E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.65|P-value:2.68E-5 ID:SGTC_2271|Compound:7849410|FD-Score:3.87|P-value:1.00E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.61|P-value:3.24E-5 ID:SGTC_2425|Compound:5628681|FD-Score:-3.37|P-value:2.54E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.63|P-value:2.98E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.21|P-value:1.82E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.67|P-value:2.56E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.88|P-value:6.60E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.06|P-value:3.34E-4 ID:SGTC_2526|Compound:patulin|FD-Score:9.90|P-value:4.23E-27 ID:SGTC_2532|Compound:xanthone|FD-Score:4.05|P-value:4.04E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:7.37|P-value:5.69E-16 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.38|P-value:2.51E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.48|P-value:5.86E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:9.43|P-value:8.42E-25 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.21|P-value:6.25E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.76|P-value:8.88E-8 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.07|P-value:8.01E-4 ID:SGTC_2931|Compound:9014674|FD-Score:2.79|P-value:9.38E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.03|P-value:9.32E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.15|P-value:5.95E-4 ID:SGTC_3246|Compound:9135460|FD-Score:4.12|P-value:2.90E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.21|P-value:1.84E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.97|P-value:5.91E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-8.55|P-value:1.01E-19 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.87|P-value:7.43E-11 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.03|P-value:9.54E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.51|P-value:5.13E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.03|P-value:3.78E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:6.37|P-value:1.87E-12 ID:SGTC_428|Compound:3448-4153|FD-Score:4.57|P-value:2.65E-7 ID:SGTC_446|Compound:go6976|FD-Score:3.11|P-value:2.75E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.43|P-value:5.65E-7 ID:SGTC_456|Compound:gingerol|FD-Score:4.61|P-value:2.07E-7 ID:SGTC_631|Compound:k072-0230|FD-Score:3.71|P-value:2.13E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.42|P-value:7.70E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:2.90|P-value:6.16E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.57|P-value:3.90E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.81|P-value:4.48E-13 ID:SGTC_763|Compound:3453-1109|FD-Score:3.59|P-value:3.56E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.18|P-value:5.44E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:2.80|P-value:8.91E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:4.43|P-value:5.72E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:2.81|P-value:8.46E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.78|P-value:9.43E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:2.86|P-value:7.01E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.79|P-value:1.47E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.63|P-value:3.03E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.08|P-value:3.05E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.94|P-value:5.22E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.83|P-value:7.89E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:2.96|P-value:4.89E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.83|P-value:8.10E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.00|P-value:4.23E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.07|P-value:3.72E-6 ID:SGTC_1530|Compound:rhein|FD-Score:3.31|P-value:1.22E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.82|P-value:8.29E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.19|P-value:1.97E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.35|P-value:2.81E-4 ID:SGTC_1949|Compound:st076024|FD-Score:2.91|P-value:6.01E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.71|P-value:1.18E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-3.56|P-value:1.19E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.10|P-value:2.88E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.79|P-value:1.45E-5 ID:SGTC_2206|Compound:7254556|FD-Score:3.32|P-value:1.18E-4 ID:SGTC_2216|Compound:7189485|FD-Score:-3.11|P-value:7.00E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.65|P-value:2.68E-5 ID:SGTC_2271|Compound:7849410|FD-Score:3.87|P-value:1.00E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.61|P-value:3.24E-5 ID:SGTC_2425|Compound:5628681|FD-Score:-3.37|P-value:2.54E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.63|P-value:2.98E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.21|P-value:1.82E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.67|P-value:2.56E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.88|P-value:6.60E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.06|P-value:3.34E-4 ID:SGTC_2526|Compound:patulin|FD-Score:9.90|P-value:4.23E-27 ID:SGTC_2532|Compound:xanthone|FD-Score:4.05|P-value:4.04E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:7.37|P-value:5.69E-16 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.38|P-value:2.51E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.48|P-value:5.86E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:9.43|P-value:8.42E-25 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.21|P-value:6.25E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.76|P-value:8.88E-8 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.07|P-value:8.01E-4 ID:SGTC_2931|Compound:9014674|FD-Score:2.79|P-value:9.38E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.03|P-value:9.32E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.15|P-value:5.95E-4 ID:SGTC_3246|Compound:9135460|FD-Score:4.12|P-value:2.90E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.21|P-value:1.84E-4

Top fitness defect scores for YHR134W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2526 patulin 9.90 37.6 µM 4.23E-27 8 2.06E-23
2 SGTC_2750 bromebric acid 9.43 70.2 µM 8.42E-25 1 2.01E-21
3 SGTC_2592 piperlongumine 7.37 83.3 µM 5.69E-16 TSC3-RPN4 4 8.54E-14
4 SGTC_369 0957-0393 6.37 4.5 µM 1.87E-12 cell wall signaling 3 9.18E-11
5 SGTC_46 0329-0187a 5.87 2.2 µM 7.43E-11 28 2.18E-9
6 SGTC_2753 fluvastatin 4.76 17.1 µM 8.88E-8 azole & statin 17 9.64E-7
7 SGTC_1987 st072290 4.71 61.9 µM 1.18E-7 6 1.23E-6
8 SGTC_456 gingerol 4.61 170.0 µM 2.07E-7 8 1.99E-6
9 SGTC_428 3448-4153 4.57 16.5 µM 2.65E-7 TSC3-RPN4 20 2.46E-6
10 SGTC_450 aminopyrene 4.43 156.0 nM 5.65E-7 21 4.72E-6
11 SGTC_910 3454-3003 4.43 490.0 µM 5.72E-7 9 4.77E-6
12 SGTC_3246 9135460 4.12 33.0 µM 2.90E-6 3 1.92E-5
13 SGTC_1491 4138-0063 4.07 26.5 µM 3.72E-6 9 2.37E-5
14 SGTC_2532 xanthone 4.05 78.9 µM 4.04E-6 26 2.54E-5
15 SGTC_28 pentachloropyridine N-oxide 3.97 1.6 µM 5.91E-6 TSC3-RPN4 70 3.52E-5
16 SGTC_2271 7849410 3.87 118.6 µM 1.00E-5 13 5.54E-5
17 SGTC_2144 5628481 3.79 200.0 µM 1.45E-5 ERG2 27 7.59E-5
18 SGTC_1100 amiodarone 3.79 5.1 µM 1.47E-5 19 7.66E-5
19 SGTC_631 k072-0230 3.71 41.5 µM 2.13E-5 60S ribosome export 22 1.06E-4
20 SGTC_2506 ethyl hematommate 3.67 54.2 µM 2.56E-5 RPP1 & pyrimidine depletion 22 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 4.84E-38 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.195 5.06E-30 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.181 4.08E-26 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.173 7.51E-24 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.167 2.57E-22 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.165 6.82E-22 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.163 2.51E-21 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.158 4.08E-20 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.157 6.97E-20 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.156 1.02E-19 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.151 1.18E-18 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.149 3.10E-18 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.141 1.80E-16 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.137 1.62E-15 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.135 4.67E-15 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data