Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
Profile for YHR138C / YHR138C

Click on Significant Values for Screen Details

Top fitness defect scores for YHR138C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_960 1222-0186 5.77 7.7 µM 1.77E-9 9 4.08E-9
2 SGTC_2427 5545055 4.93 42.8 µM 2.31E-7 4 4.22E-7
3 SGTC_2695 st077686 4.27 52.0 µM 6.34E-6 29 9.89E-6
4 SGTC_1252 0493-0875 4.15 34.8 µM 1.10E-5 25 1.67E-5
5 SGTC_3173 9105693 4.08 49.5 µM 1.49E-5 19 2.24E-5
6 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.06 63.6 µM 1.63E-5 37 2.43E-5
7 SGTC_2940 9060638 3.91 45.9 µM 3.22E-5 amide catabolism 25 4.65E-5
8 SGTC_2202 7226349 3.80 200.0 µM 5.22E-5 8 7.37E-5
9 SGTC_505 gw-5074 3.79 63.9 µM 5.25E-5 61 7.42E-5
10 SGTC_824 1304-0008 3.71 100.0 µM 7.39E-5 DNA damage response 42 1.03E-4
11 SGTC_1927 st060202 3.70 13.8 µM 7.64E-5 26 1.06E-4
12 SGTC_678 1218-2179 3.67 85.9 µM 8.93E-5 RNA pol III & RNase P/MRP 7 1.23E-4
13 SGTC_1092 toremifene 3.54 6.3 µM 1.46E-4 33 1.97E-4
14 SGTC_2757 clomiphene 3.52 4.2 µM 1.62E-4 fatty acid desaturase (OLE1) 57 2.17E-4
15 SGTC_962 1254-0300 3.52 21.5 µM 1.62E-4 38 2.18E-4
16 SGTC_419 nsc-638432 3.47 893.0 µM 1.95E-4 DNA damage response 22 2.60E-4
17 SGTC_1503 4585-0012 3.43 61.3 µM 2.32E-4 33 3.06E-4
18 SGTC_337 1315-0038 3.40 354.0 µM 2.54E-4 amide catabolism 42 3.34E-4
19 SGTC_1984 st072354 3.33 53.1 µM 3.37E-4 28 4.37E-4
20 SGTC_2562 3',7'-dimethoxyflavone 3.19 64.9 µM 5.59E-4 68 7.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.41E-19 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.103 2.32E-9 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.094 5.45E-8 YER038W-A_d YER038W-A_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
0.089 2.47E-7 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.088 3.81E-7 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.085 7.66E-7 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.082 1.95E-6 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.081 2.76E-6 YER149C PEA2 hom Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
0.073 2.30E-5 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.072 3.00E-5 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.071 3.82E-5 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.071 4.25E-5 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.070 4.46E-5 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.069 6.45E-5 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.069 6.96E-5 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy