YHR139C / SPS100

Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR139C / SPS100

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:3.73|P-value:1.86E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.46|P-value:4.81E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.73|P-value:1.87E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:6.08|P-value:3.40E-9 ID:SGTC_698|Compound:k064-0052|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.90|P-value:9.36E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.28|P-value:8.74E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.82|P-value:1.35E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.25|P-value:9.63E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.30|P-value:8.25E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.14|P-value:3.92E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.70|P-value:2.08E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.73|P-value:3.16E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.49|P-value:9.41E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.54|P-value:3.63E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.55|P-value:3.62E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.41|P-value:5.79E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.42|P-value:5.57E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:6.00|P-value:5.21E-9 ID:SGTC_1705|Compound:st027868|FD-Score:-3.45|P-value:5.02E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.83|P-value:1.33E-8 ID:SGTC_1958|Compound:st076513|FD-Score:3.34|P-value:7.27E-4 ID:SGTC_2051|Compound:5263410|FD-Score:5.10|P-value:5.82E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-4.69|P-value:3.85E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.48|P-value:4.45E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.61|P-value:2.93E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.10|P-value:4.71E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.50|P-value:4.24E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.69|P-value:3.91E-6 ID:SGTC_2308|Compound:7584454|FD-Score:-3.71|P-value:2.01E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.29|P-value:2.14E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.24|P-value:9.98E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.91|P-value:9.60E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.56|P-value:3.46E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.88|P-value:1.07E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.81|P-value:1.41E-4 ID:SGTC_2591|Compound:skatole|FD-Score:8.41|P-value:5.12E-16 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.62|P-value:2.74E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.52|P-value:7.12E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.61|P-value:2.89E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.46|P-value:4.83E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.48|P-value:4.57E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.09|P-value:4.78E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.50|P-value:4.23E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-5.15|P-value:4.62E-7 ID:SGTC_3052|Compound:9092717|FD-Score:3.40|P-value:5.89E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.59|P-value:6.02E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-3.71|P-value:2.05E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.43|P-value:5.28E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.47|P-value:4.74E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.36|P-value:6.76E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.73|P-value:1.86E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.46|P-value:4.81E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.73|P-value:1.87E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:6.08|P-value:3.40E-9 ID:SGTC_698|Compound:k064-0052|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.90|P-value:9.36E-9 ID:SGTC_795|Compound:0685-0265|FD-Score:3.28|P-value:8.74E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.82|P-value:1.35E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.25|P-value:9.63E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.30|P-value:8.25E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.14|P-value:3.92E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.70|P-value:2.08E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.73|P-value:3.16E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.49|P-value:9.41E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.54|P-value:3.63E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.55|P-value:3.62E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.41|P-value:5.79E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.42|P-value:5.57E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:6.00|P-value:5.21E-9 ID:SGTC_1705|Compound:st027868|FD-Score:-3.45|P-value:5.02E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.83|P-value:1.33E-8 ID:SGTC_1958|Compound:st076513|FD-Score:3.34|P-value:7.27E-4 ID:SGTC_2051|Compound:5263410|FD-Score:5.10|P-value:5.82E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-4.69|P-value:3.85E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.48|P-value:4.45E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.61|P-value:2.93E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.10|P-value:4.71E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.50|P-value:4.24E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.69|P-value:3.91E-6 ID:SGTC_2308|Compound:7584454|FD-Score:-3.71|P-value:2.01E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.29|P-value:2.14E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.24|P-value:9.98E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.91|P-value:9.60E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.56|P-value:3.46E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.88|P-value:1.07E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.81|P-value:1.41E-4 ID:SGTC_2591|Compound:skatole|FD-Score:8.41|P-value:5.12E-16 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.62|P-value:2.74E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.52|P-value:7.12E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.61|P-value:2.89E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.46|P-value:4.83E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.48|P-value:4.57E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.09|P-value:4.78E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.50|P-value:4.23E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-5.15|P-value:4.62E-7 ID:SGTC_3052|Compound:9092717|FD-Score:3.40|P-value:5.89E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.59|P-value:6.02E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-3.71|P-value:2.05E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.43|P-value:5.28E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.47|P-value:4.74E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.36|P-value:6.76E-4

Top fitness defect scores for YHR139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2591 skatole 8.41 100.0 µM 5.12E-16 2 1.97E-17
2 SGTC_549 1661-1316 6.08 519.0 µM 3.40E-9 2 6.09E-10
3 SGTC_1364 1653-0028 6.00 37.6 µM 5.21E-9 4 9.73E-10
4 SGTC_747 3448-8087 5.90 38.7 µM 9.36E-9 3 1.85E-9
5 SGTC_1741 st038134 5.83 10.2 µM 1.33E-8 6 2.72E-9
6 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 5.52 100.0 µM 7.12E-8 9 1.71E-8
7 SGTC_2051 5263410 5.10 176.0 µM 5.82E-7 8 1.71E-7
8 SGTC_1163 k060-0048 4.73 49.9 µM 3.16E-6 10 1.10E-6
9 SGTC_2305 7443522 4.69 69.2 µM 3.91E-6 5 1.38E-6
10 SGTC_3087 9117406 4.59 49.5 µM 6.02E-6 9 2.22E-6
11 SGTC_1180 1193-0155 4.49 285.0 µM 9.41E-6 7 3.61E-6
12 SGTC_922 1866-0035 4.14 480.0 µM 3.92E-5 excess fatty acid 51 1.72E-5
13 SGTC_2097 5376186 4.10 200.0 µM 4.71E-5 14 2.11E-5
14 SGTC_2816 7982706 4.09 58.4 µM 4.78E-5 azole & statin 47 2.15E-5
15 SGTC_2559 tetrahydrosappanone a trimethyl ether 3.91 100.0 µM 9.60E-5 16 4.60E-5
16 SGTC_151 3013-0144 3.73 2.3 µM 1.86E-4 iron homeostasis 36 9.49E-5
17 SGTC_320 4092-0846 3.73 5.3 µM 1.87E-4 ergosterol depletion effects on membrane 57 9.52E-5
18 SGTC_2603 homopterocarpin 3.61 100.0 µM 2.89E-4 57 1.54E-4
19 SGTC_2560 caryophyllene 3.56 100.0 µM 3.46E-4 27 1.87E-4
20 SGTC_1252 0493-0875 3.55 34.8 µM 3.62E-4 41 1.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 8.33E-10 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.101 5.45E-9 YBR176W ECM31 hom Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
0.089 2.36E-7 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.088 3.60E-7 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.44E-6 YNL180C RHO5 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.080 3.19E-6 YCR091W KIN82 hom Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
0.080 3.72E-6 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.079 4.26E-6 YML009C-A_d YML009C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 5.22E-6 YGR275W RTT102 hom Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress
0.078 6.15E-6 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.077 8.65E-6 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.075 1.20E-5 YOL097C WRS1 het Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
0.075 1.28E-5 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.074 1.69E-5 YIL084C SDS3 hom Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
0.072 2.87E-5 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process