YHR139C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR139C-A / YHR139C-A

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:3.18|P-value:4.30E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.16|P-value:6.21E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.33|P-value:2.36E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-4.38|P-value:2.06E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.25|P-value:4.03E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.54|P-value:1.07E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.56|P-value:8.86E-7 ID:SGTC_337|Compound:1315-0038|FD-Score:3.50|P-value:1.25E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.59|P-value:8.63E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:2.99|P-value:8.82E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.80|P-value:2.46E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:4.24|P-value:4.42E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:2.99|P-value:8.67E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.91|P-value:2.10E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.19|P-value:3.95E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.87|P-value:2.52E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.10|P-value:5.90E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.57|P-value:8.35E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.33|P-value:2.71E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:4.89|P-value:1.54E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:6.01|P-value:1.46E-10 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.31|P-value:2.93E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.04|P-value:7.22E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.21|P-value:3.87E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.57|P-value:7.82E-7 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.05|P-value:6.96E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.26|P-value:4.03E-6 ID:SGTC_1522|Compound:st012842|FD-Score:-3.29|P-value:2.68E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-5.60|P-value:2.07E-9 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.55|P-value:9.41E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.46|P-value:1.48E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.30|P-value:2.74E-4 ID:SGTC_1706|Compound:st031321|FD-Score:5.13|P-value:3.93E-8 ID:SGTC_1806|Compound:st050005|FD-Score:3.31|P-value:2.66E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.15|P-value:4.91E-4 ID:SGTC_1886|Compound:st057356|FD-Score:8.76|P-value:2.17E-20 ID:SGTC_1895|Compound:st058434|FD-Score:-3.98|P-value:1.45E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.87|P-value:2.52E-5 ID:SGTC_1906|Compound:st060206|FD-Score:7.30|P-value:1.02E-14 ID:SGTC_1966|Compound:st070145|FD-Score:-3.33|P-value:2.32E-4 ID:SGTC_1973|Compound:st070275|FD-Score:4.08|P-value:9.71E-6 ID:SGTC_2050|Compound:5263056|FD-Score:6.75|P-value:7.63E-13 ID:SGTC_2066|Compound:5222451|FD-Score:-3.72|P-value:4.64E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.75|P-value:4.21E-5 ID:SGTC_2076|Compound:5212012|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.06|P-value:6.68E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.08|P-value:5.95E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.27|P-value:3.04E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.03|P-value:1.16E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.38|P-value:1.98E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.16|P-value:4.56E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.47|P-value:1.39E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.28|P-value:2.92E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.29|P-value:2.87E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.88|P-value:2.46E-5 ID:SGTC_2925|Compound:9010536|FD-Score:4.46|P-value:1.53E-6 ID:SGTC_2934|Compound:9036370|FD-Score:4.47|P-value:1.42E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.47|P-value:1.42E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.16|P-value:4.70E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.21|P-value:3.91E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-5.10|P-value:4.14E-8 ID:SGTC_3222|Compound:9128301|FD-Score:-3.10|P-value:5.64E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.18|P-value:6.06E-6 ID:SGTC_3290|Compound:9121031|FD-Score:-4.43|P-value:1.65E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.82|P-value:3.22E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.91|P-value:1.37E-7 ID:SGTC_3313|Compound:9133968|FD-Score:3.87|P-value:2.49E-5 ID:SGTC_3314|Compound:9135860|FD-Score:6.10|P-value:8.40E-11 ID:SGTC_104|Compound:0074-0074|FD-Score:3.18|P-value:4.30E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.16|P-value:6.21E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.33|P-value:2.36E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-4.38|P-value:2.06E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.25|P-value:4.03E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.54|P-value:1.07E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.56|P-value:8.86E-7 ID:SGTC_337|Compound:1315-0038|FD-Score:3.50|P-value:1.25E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.59|P-value:8.63E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:2.99|P-value:8.82E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.80|P-value:2.46E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:4.24|P-value:4.42E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:2.99|P-value:8.67E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.91|P-value:2.10E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.19|P-value:3.95E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.87|P-value:2.52E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.10|P-value:5.90E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.57|P-value:8.35E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.33|P-value:2.71E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:4.89|P-value:1.54E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:6.01|P-value:1.46E-10 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.31|P-value:2.93E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.04|P-value:7.22E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.21|P-value:3.87E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.57|P-value:7.82E-7 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.05|P-value:6.96E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.26|P-value:4.03E-6 ID:SGTC_1522|Compound:st012842|FD-Score:-3.29|P-value:2.68E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-5.60|P-value:2.07E-9 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.55|P-value:9.41E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.46|P-value:1.48E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.30|P-value:2.74E-4 ID:SGTC_1706|Compound:st031321|FD-Score:5.13|P-value:3.93E-8 ID:SGTC_1806|Compound:st050005|FD-Score:3.31|P-value:2.66E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.15|P-value:4.91E-4 ID:SGTC_1886|Compound:st057356|FD-Score:8.76|P-value:2.17E-20 ID:SGTC_1895|Compound:st058434|FD-Score:-3.98|P-value:1.45E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.87|P-value:2.52E-5 ID:SGTC_1906|Compound:st060206|FD-Score:7.30|P-value:1.02E-14 ID:SGTC_1966|Compound:st070145|FD-Score:-3.33|P-value:2.32E-4 ID:SGTC_1973|Compound:st070275|FD-Score:4.08|P-value:9.71E-6 ID:SGTC_2050|Compound:5263056|FD-Score:6.75|P-value:7.63E-13 ID:SGTC_2066|Compound:5222451|FD-Score:-3.72|P-value:4.64E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.75|P-value:4.21E-5 ID:SGTC_2076|Compound:5212012|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.06|P-value:6.68E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.08|P-value:5.95E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.27|P-value:3.04E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.03|P-value:1.16E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.38|P-value:1.98E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.16|P-value:4.56E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.47|P-value:1.39E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.28|P-value:2.92E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.29|P-value:2.87E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.88|P-value:2.46E-5 ID:SGTC_2925|Compound:9010536|FD-Score:4.46|P-value:1.53E-6 ID:SGTC_2934|Compound:9036370|FD-Score:4.47|P-value:1.42E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.47|P-value:1.42E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.16|P-value:4.70E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.21|P-value:3.91E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-5.10|P-value:4.14E-8 ID:SGTC_3222|Compound:9128301|FD-Score:-3.10|P-value:5.64E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.18|P-value:6.06E-6 ID:SGTC_3290|Compound:9121031|FD-Score:-4.43|P-value:1.65E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.82|P-value:3.22E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.91|P-value:1.37E-7 ID:SGTC_3313|Compound:9133968|FD-Score:3.87|P-value:2.49E-5 ID:SGTC_3314|Compound:9135860|FD-Score:6.10|P-value:8.40E-11

Top fitness defect scores for YHR139C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1886 st057356 8.76 49.9 µM 2.17E-20 60S ribosome export 1 1.01E-18
2 SGTC_1906 st060206 7.30 94.7 µM 1.02E-14 2 1.47E-13
3 SGTC_2050 5263056 6.75 171.0 µM 7.63E-13 fatty acid desaturase (OLE1) 7 7.50E-12
4 SGTC_3314 9135860 6.10 59.4 µM 8.40E-11 4 5.45E-10
5 SGTC_1125 tnp00248 6.01 1.3 µM 1.46E-10 4 9.00E-10
6 SGTC_1706 st031321 5.13 10.0 µM 3.93E-8 TSC3-RPN4 6 1.48E-7
7 SGTC_3310 9130229 4.91 44.1 µM 1.37E-7 Golgi 9 4.64E-7
8 SGTC_1123 mangostin 4.89 811.3 nM 1.54E-7 mitochondrial response to ROS 18 5.16E-7
9 SGTC_817 1391-0715 4.80 46.0 µM 2.46E-7 8 7.92E-7
10 SGTC_1027 k015-0025 4.57 8.7 µM 8.35E-7 16 2.41E-6
11 SGTC_322 k048-0136 4.56 19.3 µM 8.86E-7 RSC & ERG11 8 2.55E-6
12 SGTC_2934 9036370 4.47 36.9 µM 1.42E-6 20 3.91E-6
13 SGTC_2925 9010536 4.46 32.5 µM 1.53E-6 azole & statin 32 4.19E-6
14 SGTC_1489 4065-0444 4.26 182.0 µM 4.03E-6 15 1.02E-5
15 SGTC_818 4072-2707 4.24 53.5 µM 4.42E-6 11 1.11E-5
16 SGTC_3242 9133940 4.18 49.5 µM 6.06E-6 7 1.48E-5
17 SGTC_1973 st070275 4.08 50.2 µM 9.71E-6 8 2.27E-5
18 SGTC_859 0439-0102 3.91 54.6 µM 2.10E-5 redox potentiating 16 4.59E-5
19 SGTC_2909 7941780 3.88 10.5 µM 2.46E-5 22 5.32E-5
20 SGTC_3313 9133968 3.87 57.0 µM 2.49E-5 7 5.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.49E-10 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.103 2.24E-9 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 8.30E-9 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.092 8.61E-8 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.089 2.23E-7 YKR086W PRP16 het DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step
0.087 4.00E-7 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.084 1.08E-6 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.084 1.14E-6 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.083 1.31E-6 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.078 6.32E-6 YBR065C ECM2 hom Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
0.077 7.01E-6 YKL107W_p YKL107W_p hom Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
0.076 9.89E-6 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
0.076 1.08E-5 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.073 2.21E-5 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.072 3.26E-5 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies