YHR143W / DSE2

Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR143W / DSE2

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:4.13|P-value:1.19E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.75|P-value:1.05E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.84|P-value:1.08E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:4.57|P-value:2.17E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:6.48|P-value:2.45E-9 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.27|P-value:7.66E-4 ID:SGTC_442|Compound:cape|FD-Score:4.94|P-value:4.75E-6 ID:SGTC_643|Compound:k048-0106|FD-Score:5.39|P-value:6.39E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:4.17|P-value:1.01E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.96|P-value:2.19E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.83|P-value:3.36E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.41|P-value:4.19E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.53|P-value:2.60E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.82|P-value:3.50E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.75|P-value:4.43E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.60|P-value:7.20E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.38|P-value:5.37E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.99|P-value:1.92E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.35|P-value:5.23E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:8.17|P-value:6.01E-14 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.73|P-value:1.27E-7 ID:SGTC_1605|Compound:st000082|FD-Score:4.21|P-value:8.82E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.87|P-value:2.93E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.36|P-value:5.02E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.99|P-value:1.94E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.53|P-value:8.93E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.38|P-value:4.60E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.94|P-value:2.29E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.22|P-value:8.57E-5 ID:SGTC_1904|Compound:st060225|FD-Score:3.54|P-value:8.58E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.55|P-value:8.31E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.00|P-value:1.85E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.94|P-value:2.29E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.50|P-value:9.98E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.91|P-value:2.55E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.98|P-value:2.03E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.13|P-value:1.17E-4 ID:SGTC_2480|Compound:5767542|FD-Score:6.71|P-value:6.46E-10 ID:SGTC_2556|Compound:citropten|FD-Score:4.36|P-value:5.06E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.67|P-value:5.70E-4 ID:SGTC_2643|Compound:anethole|FD-Score:4.04|P-value:1.61E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.69|P-value:1.53E-7 ID:SGTC_2722|Compound:naftopidil|FD-Score:5.11|P-value:2.31E-6 ID:SGTC_2819|Compound:7996655|FD-Score:4.48|P-value:3.21E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.34|P-value:6.04E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.32|P-value:5.93E-5 ID:SGTC_2921|Compound:7974240|FD-Score:7.35|P-value:1.41E-11 ID:SGTC_2924|Compound:9010168|FD-Score:-6.29|P-value:1.24E-9 ID:SGTC_2928|Compound:9011484|FD-Score:3.59|P-value:7.50E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.26|P-value:7.33E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.61|P-value:6.89E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.29|P-value:6.61E-5 ID:SGTC_2950|Compound:9072895|FD-Score:6.29|P-value:6.96E-9 ID:SGTC_3001|Compound:9076041|FD-Score:5.72|P-value:1.34E-7 ID:SGTC_3045|Compound:9092950|FD-Score:3.52|P-value:9.35E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.36|P-value:4.97E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.90|P-value:2.66E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.28|P-value:6.74E-5 ID:SGTC_3101|Compound:9120531|FD-Score:4.24|P-value:7.76E-5 ID:SGTC_3137|Compound:9097352|FD-Score:6.12|P-value:1.72E-8 ID:SGTC_3188|Compound:9110789|FD-Score:4.15|P-value:1.10E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.09|P-value:1.35E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.57|P-value:2.79E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.85|P-value:3.15E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.13|P-value:1.19E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.75|P-value:1.05E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.84|P-value:1.08E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:4.57|P-value:2.17E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:6.48|P-value:2.45E-9 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.27|P-value:7.66E-4 ID:SGTC_442|Compound:cape|FD-Score:4.94|P-value:4.75E-6 ID:SGTC_643|Compound:k048-0106|FD-Score:5.39|P-value:6.39E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:4.17|P-value:1.01E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.96|P-value:2.19E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.83|P-value:3.36E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.41|P-value:4.19E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.53|P-value:2.60E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.82|P-value:3.50E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.75|P-value:4.43E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.60|P-value:7.20E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.38|P-value:5.37E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.99|P-value:1.92E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.35|P-value:5.23E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:8.17|P-value:6.01E-14 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.73|P-value:1.27E-7 ID:SGTC_1605|Compound:st000082|FD-Score:4.21|P-value:8.82E-5 ID:SGTC_1646|Compound:st011709|FD-Score:3.87|P-value:2.93E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.36|P-value:5.02E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.99|P-value:1.94E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.53|P-value:8.93E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.38|P-value:4.60E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.94|P-value:2.29E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.22|P-value:8.57E-5 ID:SGTC_1904|Compound:st060225|FD-Score:3.54|P-value:8.58E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.55|P-value:8.31E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.00|P-value:1.85E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.94|P-value:2.29E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.50|P-value:9.98E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.91|P-value:2.55E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.98|P-value:2.03E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.13|P-value:1.17E-4 ID:SGTC_2480|Compound:5767542|FD-Score:6.71|P-value:6.46E-10 ID:SGTC_2556|Compound:citropten|FD-Score:4.36|P-value:5.06E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.67|P-value:5.70E-4 ID:SGTC_2643|Compound:anethole|FD-Score:4.04|P-value:1.61E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.69|P-value:1.53E-7 ID:SGTC_2722|Compound:naftopidil|FD-Score:5.11|P-value:2.31E-6 ID:SGTC_2819|Compound:7996655|FD-Score:4.48|P-value:3.21E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.34|P-value:6.04E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.32|P-value:5.93E-5 ID:SGTC_2921|Compound:7974240|FD-Score:7.35|P-value:1.41E-11 ID:SGTC_2924|Compound:9010168|FD-Score:-6.29|P-value:1.24E-9 ID:SGTC_2928|Compound:9011484|FD-Score:3.59|P-value:7.50E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.26|P-value:7.33E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.61|P-value:6.89E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.29|P-value:6.61E-5 ID:SGTC_2950|Compound:9072895|FD-Score:6.29|P-value:6.96E-9 ID:SGTC_3001|Compound:9076041|FD-Score:5.72|P-value:1.34E-7 ID:SGTC_3045|Compound:9092950|FD-Score:3.52|P-value:9.35E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.36|P-value:4.97E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.90|P-value:2.66E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.28|P-value:6.74E-5 ID:SGTC_3101|Compound:9120531|FD-Score:4.24|P-value:7.76E-5 ID:SGTC_3137|Compound:9097352|FD-Score:6.12|P-value:1.72E-8 ID:SGTC_3188|Compound:9110789|FD-Score:4.15|P-value:1.10E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.09|P-value:1.35E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.57|P-value:2.79E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.85|P-value:3.15E-4

Top fitness defect scores for YHR143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1585 2',4'-dihydroxychalcone 8.17 10.4 µM 6.01E-14 4 1.53E-16
2 SGTC_2921 7974240 7.35 10.7 µM 1.41E-11 9 1.00E-13
3 SGTC_2480 5767542 6.71 37.2 µM 6.46E-10 1 9.47E-12
4 SGTC_367 0335-0881 6.48 7.1 µM 2.45E-9 ubiquinone biosynthesis & proteasome 20 4.64E-11
5 SGTC_2950 9072895 6.29 21.5 µM 6.96E-9 6 1.61E-10
6 SGTC_3137 9097352 6.12 49.5 µM 1.72E-8 5 4.72E-10
7 SGTC_1601 4'-hydroxyflavanone 5.73 55.5 µM 1.27E-7 RPP1 & pyrimidine depletion 13 5.11E-9
8 SGTC_3001 9076041 5.72 71.4 µM 1.34E-7 3 5.44E-9
9 SGTC_2689 tacrolimus 5.69 100.0 µM 1.53E-7 14 6.42E-9
10 SGTC_643 k048-0106 5.39 28.4 µM 6.39E-7 RSC & ERG11 4 3.52E-8
11 SGTC_2722 naftopidil 5.11 47.2 µM 2.31E-6 2 1.63E-7
12 SGTC_442 cape 4.94 100.0 µM 4.75E-6 3 3.88E-7
13 SGTC_279 1273-0055 4.75 2.9 µM 1.05E-5 azole & statin 26 1.01E-6
14 SGTC_357 1325-0123 4.57 420.0 µM 2.17E-5 2 2.39E-6
15 SGTC_1112 tnp00069 4.53 1.2 µM 2.60E-5 14 2.97E-6
16 SGTC_2819 7996655 4.48 46.4 µM 3.21E-5 10 3.82E-6
17 SGTC_1019 4262-0212 4.41 3.4 µM 4.19E-5 ergosterol depletion effects on membrane 47 5.25E-6
18 SGTC_1799 st045822 4.38 46.1 µM 4.60E-5 9 5.88E-6
19 SGTC_3050 9093513 4.36 49.5 µM 4.97E-5 13 6.45E-6
20 SGTC_1651 st011928 4.36 86.1 µM 5.02E-5 RSC complex & mRNA processing 10 6.53E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.19E-11 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.085 8.82E-7 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.081 2.50E-6 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.069 6.14E-5 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.067 1.10E-4 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.067 1.13E-4 YCR099C_p YCR099C_p hom Putative protein of unknown function
0.066 1.29E-4 YOL023W IFM1 hom Mitochondrial translation initiation factor 2
0.065 1.61E-4 YNL207W RIO2 het Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
0.065 1.70E-4 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.064 1.98E-4 YOR255W OSW1 hom Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
0.064 2.14E-4 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.062 3.14E-4 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.061 4.13E-4 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.060 4.74E-4 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.060 5.13E-4 YPL094C SEC62 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER