YHR143W-A / RPC10

RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR143W-A / RPC10

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:-4.98|P-value:7.58E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.71|P-value:1.61E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.70|P-value:1.65E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.61|P-value:2.31E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-4.11|P-value:3.52E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.35|P-value:5.75E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.19|P-value:2.52E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:-4.00|P-value:5.36E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.42|P-value:4.46E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-4.08|P-value:3.90E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.18|P-value:9.87E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.63|P-value:2.16E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.67|P-value:1.90E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-4.49|P-value:7.10E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-3.20|P-value:9.42E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-4.04|P-value:4.51E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.32|P-value:9.19E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-9.36|P-value:1.20E-19 ID:SGTC_2075|Compound:5212009|FD-Score:-4.46|P-value:7.99E-6 ID:SGTC_2076|Compound:5212012|FD-Score:-3.64|P-value:2.05E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-4.96|P-value:8.33E-7 ID:SGTC_2119|Compound:5528445|FD-Score:-3.24|P-value:8.17E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.20|P-value:2.40E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.37|P-value:7.65E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.30|P-value:9.77E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-5.10|P-value:4.33E-7 ID:SGTC_2997|Compound:9067075|FD-Score:-4.65|P-value:3.47E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-4.46|P-value:7.94E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-3.56|P-value:2.79E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-6.72|P-value:4.94E-11 ID:SGTC_3329|Compound:9141233|FD-Score:-3.52|P-value:3.23E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.55|P-value:2.92E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.98|P-value:7.58E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.71|P-value:1.61E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.70|P-value:1.65E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.61|P-value:2.31E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-4.11|P-value:3.52E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.35|P-value:5.75E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.19|P-value:2.52E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:-4.00|P-value:5.36E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.42|P-value:4.46E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-4.08|P-value:3.90E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.18|P-value:9.87E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.63|P-value:2.16E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.67|P-value:1.90E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-4.49|P-value:7.10E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-3.20|P-value:9.42E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-4.04|P-value:4.51E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.32|P-value:9.19E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-9.36|P-value:1.20E-19 ID:SGTC_2075|Compound:5212009|FD-Score:-4.46|P-value:7.99E-6 ID:SGTC_2076|Compound:5212012|FD-Score:-3.64|P-value:2.05E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-4.96|P-value:8.33E-7 ID:SGTC_2119|Compound:5528445|FD-Score:-3.24|P-value:8.17E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.20|P-value:2.40E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.37|P-value:7.65E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.30|P-value:9.77E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-5.10|P-value:4.33E-7 ID:SGTC_2997|Compound:9067075|FD-Score:-4.65|P-value:3.47E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-4.46|P-value:7.94E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-3.56|P-value:2.79E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-6.72|P-value:4.94E-11 ID:SGTC_3329|Compound:9141233|FD-Score:-3.52|P-value:3.23E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.55|P-value:2.92E-4

Top fitness defect scores for YHR143W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2387 9077560 3.37 195.1 µM 7.65E-4 15 3.72E-4 0.06
2 SGTC_2012 4023501 3.32 200.0 µM 9.19E-4 19 4.56E-4 0.06
3 SGTC_2837 9008476 3.30 45.5 µM 9.77E-4 11 4.88E-4 0.11
4 SGTC_3045 9092950 3.19 49.5 µM 0.00139 8 7.21E-4 0.25
5 SGTC_2205 7238770 3.17 200.0 µM 0.00147 4 7.66E-4 0.07
6 SGTC_1528 arabinosylhypoxanthine 3.16 74.6 µM 0.00149 17 7.77E-4 0.04
7 SGTC_2996 9066192 3.15 71.4 µM 0.00155 18 8.11E-4 0.10
8 SGTC_2845 9003024 3.15 43.0 µM 0.00155 amide catabolism 23 8.12E-4 0.14
9 SGTC_450 aminopyrene 3.10 156.0 nM 0.00181 13 9.64E-4 0.01
10 SGTC_428 3448-4153 3.08 16.5 µM 0.00191 TSC3-RPN4 20 0.00102 0.06
11 SGTC_148 3253-0744 3.06 288.0 µM 0.00205 14 0.00111 0.01
12 SGTC_549 1661-1316 3.04 519.0 µM 0.00220 15 0.00119 0.03
13 SGTC_1584 6-fluoro-dl-tryptophan 3.01 90.0 µM 0.00239 mitochondrial processes 16 0.00131 0.06
14 SGTC_1791 st048313 2.99 56.1 µM 0.00254 8 0.00140 0.02
15 SGTC_2370 9071495 2.95 200.0 µM 0.00284 mitochondrial processes 22 0.00158 0.05
16 SGTC_675 1309-0189 2.95 238.0 µM 0.00287 12 0.00161 0.11
17 SGTC_2715 st079500 2.92 56.4 µM 0.00306 10 0.00173 0.01
18 SGTC_2373 9071805 2.92 200.0 µM 0.00313 8 0.00177 0.08
19 SGTC_121 0557-0495 2.91 61.3 µM 0.00321 calcium & mitochondrial duress 23 0.00182 0.03
20 SGTC_844 0330-0132 2.89 15.3 µM 0.00337 12 0.00192 0.28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.07E-28 YPR187W RPO26 het RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
0.092 1.08E-7 YDR463W STP1 hom Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
0.091 1.57E-7 YKL169C_d YKL169C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38
0.089 2.34E-7 YDL193W NUS1 het Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
0.078 5.58E-6 YOR199W_d YOR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078 6.00E-6 YLR448W RPL6B hom Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication
0.076 1.07E-5 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.076 1.12E-5 YAL041W CDC24 het Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.075 1.24E-5 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.075 1.32E-5 YJL177W RPL17B hom Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication
0.072 3.00E-5 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.072 3.23E-5 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.071 3.70E-5 YER044C ERG28 hom Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
0.071 4.30E-5 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.070 5.19E-5 YPL271W ATP15 hom Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated