YHR146W / CRP1

Protein that binds to cruciform DNA structures

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR146W / CRP1

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.31|P-value:8.73E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.44|P-value:4.37E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.31|P-value:8.50E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.18|P-value:3.72E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.58|P-value:3.50E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.37|P-value:5.49E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.79|P-value:2.70E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.45|P-value:5.34E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.10|P-value:4.91E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.16|P-value:3.89E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.41|P-value:6.15E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.42|P-value:1.38E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.41|P-value:4.83E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.44|P-value:5.57E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:4.01|P-value:7.04E-5 ID:SGTC_1705|Compound:st027868|FD-Score:5.18|P-value:4.14E-7 ID:SGTC_1713|Compound:st033146|FD-Score:-4.07|P-value:4.12E-5 ID:SGTC_1721|Compound:st082152|FD-Score:3.33|P-value:8.13E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.54|P-value:4.04E-4 ID:SGTC_1910|Compound:st062352|FD-Score:6.21|P-value:1.67E-9 ID:SGTC_1938|Compound:st074717|FD-Score:3.97|P-value:8.40E-5 ID:SGTC_1940|Compound:st075990|FD-Score:-6.15|P-value:1.56E-9 ID:SGTC_1950|Compound:st077106|FD-Score:9.55|P-value:4.02E-20 ID:SGTC_1953|Compound:st076800|FD-Score:7.23|P-value:2.77E-12 ID:SGTC_1975|Compound:st070967|FD-Score:-3.39|P-value:5.07E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.40|P-value:4.98E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:2.55E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.57|P-value:7.01E-6 ID:SGTC_2198|Compound:6589944|FD-Score:4.92|P-value:1.47E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.00|P-value:7.48E-5 ID:SGTC_2269|Compound:7935389|FD-Score:7.27|P-value:2.14E-12 ID:SGTC_2274|Compound:7947094|FD-Score:4.67|P-value:4.61E-6 ID:SGTC_2326|Compound:6164455|FD-Score:-3.37|P-value:5.49E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.49|P-value:3.70E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.30|P-value:6.97E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-5.11|P-value:4.09E-7 ID:SGTC_2357|Compound:9067248|FD-Score:6.39|P-value:5.75E-10 ID:SGTC_2480|Compound:5767542|FD-Score:3.52|P-value:4.29E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.34|P-value:7.81E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.79|P-value:1.24E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.83|P-value:2.24E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.92|P-value:7.62E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.19|P-value:9.85E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.42|P-value:8.86E-8 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-5.61|P-value:3.22E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.34|P-value:7.79E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.45|P-value:1.17E-5 ID:SGTC_3010|Compound:9080089|FD-Score:3.43|P-value:5.81E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.98|P-value:1.09E-6 ID:SGTC_3170|Compound:9103054|FD-Score:3.37|P-value:7.05E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.53|P-value:4.15E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.51|P-value:3.37E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.31|P-value:8.73E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.44|P-value:4.37E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.31|P-value:8.50E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.18|P-value:3.72E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.58|P-value:3.50E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.37|P-value:5.49E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.79|P-value:2.70E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.45|P-value:5.34E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.10|P-value:4.91E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.16|P-value:3.89E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.41|P-value:6.15E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.42|P-value:1.38E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.41|P-value:4.83E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.44|P-value:5.57E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:4.01|P-value:7.04E-5 ID:SGTC_1705|Compound:st027868|FD-Score:5.18|P-value:4.14E-7 ID:SGTC_1713|Compound:st033146|FD-Score:-4.07|P-value:4.12E-5 ID:SGTC_1721|Compound:st082152|FD-Score:3.33|P-value:8.13E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.54|P-value:4.04E-4 ID:SGTC_1910|Compound:st062352|FD-Score:6.21|P-value:1.67E-9 ID:SGTC_1938|Compound:st074717|FD-Score:3.97|P-value:8.40E-5 ID:SGTC_1940|Compound:st075990|FD-Score:-6.15|P-value:1.56E-9 ID:SGTC_1950|Compound:st077106|FD-Score:9.55|P-value:4.02E-20 ID:SGTC_1953|Compound:st076800|FD-Score:7.23|P-value:2.77E-12 ID:SGTC_1975|Compound:st070967|FD-Score:-3.39|P-value:5.07E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.40|P-value:4.98E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:2.55E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.57|P-value:7.01E-6 ID:SGTC_2198|Compound:6589944|FD-Score:4.92|P-value:1.47E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.00|P-value:7.48E-5 ID:SGTC_2269|Compound:7935389|FD-Score:7.27|P-value:2.14E-12 ID:SGTC_2274|Compound:7947094|FD-Score:4.67|P-value:4.61E-6 ID:SGTC_2326|Compound:6164455|FD-Score:-3.37|P-value:5.49E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.49|P-value:3.70E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.30|P-value:6.97E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-5.11|P-value:4.09E-7 ID:SGTC_2357|Compound:9067248|FD-Score:6.39|P-value:5.75E-10 ID:SGTC_2480|Compound:5767542|FD-Score:3.52|P-value:4.29E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.34|P-value:7.81E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.79|P-value:1.24E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.83|P-value:2.24E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.92|P-value:7.62E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.19|P-value:9.85E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.42|P-value:8.86E-8 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-5.61|P-value:3.22E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.34|P-value:7.79E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.45|P-value:1.17E-5 ID:SGTC_3010|Compound:9080089|FD-Score:3.43|P-value:5.81E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.98|P-value:1.09E-6 ID:SGTC_3170|Compound:9103054|FD-Score:3.37|P-value:7.05E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.53|P-value:4.15E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.51|P-value:3.37E-4

Top fitness defect scores for YHR146W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1950 st077106 9.55 7.2 µM 4.02E-20 RNA processing & uracil transport 1 6.25E-22
2 SGTC_2269 7935389 7.27 174.4 µM 2.14E-12 tubulin folding & SWR complex 5 1.77E-13
3 SGTC_1953 st076800 7.23 12.1 µM 2.77E-12 6 2.35E-13
4 SGTC_2357 9067248 6.39 200.0 µM 5.75E-10 2 8.07E-11
5 SGTC_1910 st062352 6.21 60.4 µM 1.67E-9 7 2.60E-10
6 SGTC_1705 st027868 5.18 56.3 µM 4.14E-7 2 1.08E-7
7 SGTC_3029 9088683 4.98 49.5 µM 1.09E-6 10 3.13E-7
8 SGTC_2198 6589944 4.92 200.0 µM 1.47E-6 10 4.34E-7
9 SGTC_2517 totarol 4.83 10.0 µM 2.24E-6 8 6.88E-7
10 SGTC_803 4488-1585 4.79 147.0 µM 2.70E-6 4 8.42E-7
11 SGTC_2274 7947094 4.67 46.1 µM 4.61E-6 13 1.51E-6
12 SGTC_2087 5276107 4.57 200.0 µM 7.01E-6 11 2.40E-6
13 SGTC_2957 9076800 4.45 11.5 µM 1.17E-5 18 4.21E-6
14 SGTC_1623 st003709 4.42 20.3 µM 1.38E-5 calcium & mitochondrial duress 51 5.04E-6
15 SGTC_307 1501-1223 4.18 22.3 µM 3.72E-5 10 1.49E-5
16 SGTC_1429 4049-0205 4.16 9.5 µM 3.89E-5 9 1.57E-5
17 SGTC_1389 3405-0187 4.10 19.0 µM 4.91E-5 11 2.02E-5
18 SGTC_1693 xanthone 4.01 101.9 µM 7.04E-5 DNA damage response 17 3.00E-5
19 SGTC_2252 omeprazole 4.00 400.0 µM 7.48E-5 8 3.20E-5
20 SGTC_1938 st074717 3.97 56.4 µM 8.40E-5 12 3.64E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.06E-9 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.088 2.97E-7 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.084 1.13E-6 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.083 1.39E-6 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.083 1.45E-6 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.083 1.65E-6 YPL064C CWC27 hom Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.073 2.29E-5 YHL041W_d YHL041W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.073 2.38E-5 YOR366W_d YOR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.069 5.74E-5 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.068 9.11E-5 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.065 1.54E-4 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.065 1.67E-4 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.064 1.89E-4 YMR246W FAA4 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
0.064 2.03E-4 YIR031C DAL7 hom Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.064 2.15E-4 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress