HIPHOP chemogenomics database

YHR146W / CRP1

Protein that binds to cruciform DNA structures

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR146W / CRP1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR146W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1950	st077106	9.55	7.2 µM	4.02E-20	RNA processing & uracil transport	1	6.25E-22
2	SGTC_2269	7935389	7.27	174.4 µM	2.14E-12	tubulin folding & SWR complex	5	1.77E-13
3	SGTC_1953	st076800	7.23	12.1 µM	2.77E-12		6	2.35E-13
4	SGTC_2357	9067248	6.39	200.0 µM	5.75E-10		2	8.07E-11
5	SGTC_1910	st062352	6.21	60.4 µM	1.67E-9		7	2.60E-10
6	SGTC_1705	st027868	5.18	56.3 µM	4.14E-7		2	1.08E-7
7	SGTC_3029	9088683	4.98	49.5 µM	1.09E-6		10	3.13E-7
8	SGTC_2198	6589944	4.92	200.0 µM	1.47E-6		10	4.34E-7
9	SGTC_2517	totarol	4.83	10.0 µM	2.24E-6		8	6.88E-7
10	SGTC_803	4488-1585	4.79	147.0 µM	2.70E-6		4	8.42E-7
11	SGTC_2274	7947094	4.67	46.1 µM	4.61E-6		13	1.51E-6
12	SGTC_2087	5276107	4.57	200.0 µM	7.01E-6		11	2.40E-6
13	SGTC_2957	9076800	4.45	11.5 µM	1.17E-5		18	4.21E-6
14	SGTC_1623	st003709	4.42	20.3 µM	1.38E-5	calcium & mitochondrial duress	51	5.04E-6
15	SGTC_307	1501-1223	4.18	22.3 µM	3.72E-5		10	1.49E-5
16	SGTC_1429	4049-0205	4.16	9.5 µM	3.89E-5		9	1.57E-5
17	SGTC_1389	3405-0187	4.10	19.0 µM	4.91E-5		11	2.02E-5
18	SGTC_1693	xanthone	4.01	101.9 µM	7.04E-5	DNA damage response	17	3.00E-5
19	SGTC_2252	omeprazole	4.00	400.0 µM	7.48E-5		8	3.20E-5
20	SGTC_1938	st074717	3.97	56.4 µM	8.40E-5		12	3.64E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.100	6.06E-9	YJL093C	TOK1	hom	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.088	2.97E-7	YPL147W	PXA1	hom	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.084	1.13E-6	YOL107W_p	YOL107W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.083	1.39E-6	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.083	1.45E-6	YGL001C	ERG26	het	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.083	1.65E-6	YPL064C	CWC27	hom	Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.073	2.29E-5	YHL041W_d	YHL041W_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.073	2.38E-5	YOR366W_d	YOR366W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.069	5.74E-5	YOL061W	PRS5	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.068	9.11E-5	YPL043W	NOP4	het	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.065	1.54E-4	YDR228C	PCF11	het	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.065	1.67E-4	YLR276C	DBP9	het	DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.064	1.89E-4	YMR246W	FAA4	hom	Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
0.064	2.03E-4	YIR031C	DAL7	hom	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.064	2.15E-4	YDR129C	SAC6	hom	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress