YHR147C / MRPL6

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR147C / MRPL6

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.67|P-value:8.58E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.39|P-value:9.31E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.41|P-value:8.49E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.51|P-value:1.68E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.48|P-value:6.89E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.92|P-value:1.55E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.23|P-value:6.35E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:6.98|P-value:6.49E-11 ID:SGTC_211|Compound:3455-0679|FD-Score:4.80|P-value:5.07E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.39|P-value:9.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:1.29E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.20|P-value:5.71E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:7.74|P-value:4.76E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.04|P-value:1.03E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.53|P-value:5.88E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.06|P-value:8.31E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.45|P-value:2.08E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.85|P-value:1.96E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.50|P-value:6.54E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.99|P-value:2.16E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.78|P-value:2.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.43|P-value:7.98E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.35|P-value:3.17E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.49|P-value:1.78E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.50|P-value:6.50E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.98|P-value:1.24E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.79|P-value:2.43E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.60|P-value:4.71E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.10|P-value:1.31E-6 ID:SGTC_1658|Compound:st012944|FD-Score:-4.21|P-value:4.74E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.52|P-value:5.99E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.83|P-value:3.40E-8 ID:SGTC_1846|Compound:st056244|FD-Score:3.42|P-value:8.31E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.07|P-value:9.05E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.97|P-value:2.40E-6 ID:SGTC_1932|Compound:st074806|FD-Score:3.44|P-value:7.79E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.97|P-value:1.64E-8 ID:SGTC_1945|Compound:st075991|FD-Score:-4.20|P-value:4.97E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-5.32|P-value:4.07E-7 ID:SGTC_1950|Compound:st077106|FD-Score:-6.12|P-value:7.27E-9 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-8.42|P-value:3.19E-15 ID:SGTC_2016|Compound:5121758|FD-Score:4.06|P-value:9.26E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.38|P-value:9.43E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.14|P-value:6.98E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.83|P-value:2.13E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.71|P-value:3.23E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.55|P-value:5.52E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.08|P-value:8.77E-5 ID:SGTC_2434|Compound:5670830|FD-Score:4.57|P-value:1.31E-5 ID:SGTC_2526|Compound:patulin|FD-Score:5.33|P-value:4.51E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:5.13|P-value:1.15E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.53|P-value:1.52E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.62|P-value:1.06E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:7.04|P-value:4.44E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.96|P-value:1.96E-8 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.39|P-value:2.64E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.00|P-value:1.18E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.39|P-value:2.36E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.52|P-value:5.48E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:9.67E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.52|P-value:6.07E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.42|P-value:8.23E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.41|P-value:8.51E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.78|P-value:5.33E-6 ID:SGTC_3333|Compound:9141820|FD-Score:-4.49|P-value:1.54E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.67|P-value:8.58E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.39|P-value:9.31E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.41|P-value:8.49E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.51|P-value:1.68E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.48|P-value:6.89E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.92|P-value:1.55E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.23|P-value:6.35E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:6.98|P-value:6.49E-11 ID:SGTC_211|Compound:3455-0679|FD-Score:4.80|P-value:5.07E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.39|P-value:9.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:1.29E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.20|P-value:5.71E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:7.74|P-value:4.76E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:4.04|P-value:1.03E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.53|P-value:5.88E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.06|P-value:8.31E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.45|P-value:2.08E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.85|P-value:1.96E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.50|P-value:6.54E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.99|P-value:2.16E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.78|P-value:2.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.43|P-value:7.98E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.35|P-value:3.17E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.49|P-value:1.78E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.50|P-value:6.50E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.00|P-value:1.16E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.98|P-value:1.24E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.79|P-value:2.43E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.60|P-value:4.71E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.10|P-value:1.31E-6 ID:SGTC_1658|Compound:st012944|FD-Score:-4.21|P-value:4.74E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.52|P-value:5.99E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.83|P-value:3.40E-8 ID:SGTC_1846|Compound:st056244|FD-Score:3.42|P-value:8.31E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.07|P-value:9.05E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.97|P-value:2.40E-6 ID:SGTC_1932|Compound:st074806|FD-Score:3.44|P-value:7.79E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.97|P-value:1.64E-8 ID:SGTC_1945|Compound:st075991|FD-Score:-4.20|P-value:4.97E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-5.32|P-value:4.07E-7 ID:SGTC_1950|Compound:st077106|FD-Score:-6.12|P-value:7.27E-9 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-8.42|P-value:3.19E-15 ID:SGTC_2016|Compound:5121758|FD-Score:4.06|P-value:9.26E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.38|P-value:9.43E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.14|P-value:6.98E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.83|P-value:2.13E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.71|P-value:3.23E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.55|P-value:5.52E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.08|P-value:8.77E-5 ID:SGTC_2434|Compound:5670830|FD-Score:4.57|P-value:1.31E-5 ID:SGTC_2526|Compound:patulin|FD-Score:5.33|P-value:4.51E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:5.13|P-value:1.15E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.53|P-value:1.52E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.62|P-value:1.06E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:7.04|P-value:4.44E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.96|P-value:1.96E-8 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.39|P-value:2.64E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.00|P-value:1.18E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.39|P-value:2.36E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.52|P-value:5.48E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:9.67E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.52|P-value:6.07E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.42|P-value:8.23E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.41|P-value:8.51E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.78|P-value:5.33E-6 ID:SGTC_3333|Compound:9141820|FD-Score:-4.49|P-value:1.54E-5

Top fitness defect scores for YHR147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.00 5.3 µM 1.29E-20 194 6.59E-24
2 SGTC_310 1273-0058 7.74 1.1 µM 4.76E-13 mitochondrial stress 99 4.82E-15
3 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 7.04 100.0 µM 4.44E-11 1 9.78E-13
4 SGTC_173 1273-0061 6.98 2.7 µM 6.49E-11 mitochondrial stress 87 1.53E-12
5 SGTC_275 trichlorophene 6.20 5.7 µM 5.71E-9 mitochondrial stress 110 2.89E-10
6 SGTC_2639 lactacystin 5.96 53.0 µM 1.96E-8 4 1.22E-9
7 SGTC_2526 patulin 5.33 37.6 µM 4.51E-7 36 4.79E-8
8 SGTC_2611 pyromycin 5.13 23.9 µM 1.15E-6 8 1.43E-7
9 SGTC_1623 st003709 5.10 20.3 µM 1.31E-6 calcium & mitochondrial duress 27 1.66E-7
10 SGTC_767 0929-0023 4.99 86.0 µM 2.16E-6 TRP & mitochondrial translation 38 2.98E-7
11 SGTC_1922 5578187 4.97 25.0 µM 2.40E-6 TRP & mitochondrial translation 9 3.38E-7
12 SGTC_211 3455-0679 4.80 143.5 µM 5.07E-6 8 8.11E-7
13 SGTC_3323 9138564 4.78 53.9 µM 5.33E-6 11 8.60E-7
14 SGTC_10 0279-0212 4.67 42.6 µM 8.58E-6 TRP & mitochondrial translation 77 1.50E-6
15 SGTC_2614 arthonioic acid 4.62 13.4 µM 1.06E-5 13 1.93E-6
16 SGTC_2434 5670830 4.57 169.9 µM 1.31E-5 13 2.46E-6
17 SGTC_63 0099-0242 4.51 26.7 µM 1.68E-5 mitochondrial stress 70 3.29E-6
18 SGTC_1204 4049-0315 4.49 18.3 µM 1.78E-5 14 3.53E-6
19 SGTC_601 0986-0029 4.45 62.9 µM 2.08E-5 calcium & mitochondrial duress 24 4.21E-6
20 SGTC_2640 pentamidine 4.39 10.4 µM 2.64E-5 mitochondrial processes 22 5.58E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.419 1.07E-142 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.414 9.27E-139 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.396 3.24E-126 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.395 1.12E-125 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.382 4.07E-117 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.376 5.33E-113 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.375 3.04E-112 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.374 1.25E-111 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.373 3.23E-111 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.369 1.28E-108 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.369 2.05E-108 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.368 4.42E-108 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.368 9.83E-108 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.367 4.40E-107 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.365 1.64E-105 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules