YHR148W / IMP3

Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR148W / IMP3

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:-3.76|P-value:3.28E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.59|P-value:7.27E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.82|P-value:2.64E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.60|P-value:6.94E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:4.38|P-value:4.95E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.22|P-value:6.55E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:5.05|P-value:3.47E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.56|P-value:6.16E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.83|P-value:2.61E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.80|P-value:3.64E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.70|P-value:5.07E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.43|P-value:9.11E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.74|P-value:4.44E-4 ID:SGTC_1591|Compound:genipin|FD-Score:4.45|P-value:3.85E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.89|P-value:2.70E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-4.28|P-value:5.32E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.46|P-value:8.31E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.62|P-value:6.49E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.92|P-value:2.52E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.53|P-value:8.65E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-3.83|P-value:2.57E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.88|P-value:2.19E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:2.11E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.02|P-value:1.80E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:6.48|P-value:3.70E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.94|P-value:5.42E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.13|P-value:9.17E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.69|P-value:5.32E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.23|P-value:8.56E-5 ID:SGTC_2975|Compound:9084847|FD-Score:4.17|P-value:1.05E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.56|P-value:6.27E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.76|P-value:3.28E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.59|P-value:7.27E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.82|P-value:2.64E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.60|P-value:6.94E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:4.38|P-value:4.95E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.22|P-value:6.55E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:5.05|P-value:3.47E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.56|P-value:6.16E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.83|P-value:2.61E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.80|P-value:3.64E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.70|P-value:5.07E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.43|P-value:9.11E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.74|P-value:4.44E-4 ID:SGTC_1591|Compound:genipin|FD-Score:4.45|P-value:3.85E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.89|P-value:2.70E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-4.28|P-value:5.32E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.46|P-value:8.31E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.62|P-value:6.49E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.92|P-value:2.52E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.53|P-value:8.65E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-3.83|P-value:2.57E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.88|P-value:2.19E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:2.11E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.02|P-value:1.80E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:6.48|P-value:3.70E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.94|P-value:5.42E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.13|P-value:9.17E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.69|P-value:5.32E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.23|P-value:8.56E-5 ID:SGTC_2975|Compound:9084847|FD-Score:4.17|P-value:1.05E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.56|P-value:6.27E-4

Top fitness defect scores for YHR148W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2635 hydroquinidine 6.48 100.0 µM 3.70E-9 1 4.53E-11 2.72
2 SGTC_647 0140-0236 5.05 81.0 µM 3.47E-6 3 2.23E-7 0.43
3 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.94 100.0 µM 5.42E-6 3 3.86E-7 0.82
4 SGTC_1591 genipin 4.45 88.4 µM 3.85E-5 mitochondrial processes 3 4.39E-6 0.51
5 SGTC_507 nimesulide 4.38 162.0 µM 4.95E-5 1 6.01E-6 0.77
6 SGTC_2927 9011802 4.23 47.9 µM 8.56E-5 8 1.18E-5 0.43
7 SGTC_2975 9084847 4.17 53.7 µM 1.05E-4 9 1.53E-5 0.04
8 SGTC_2613 3',4'-dimethoxydalbergione 4.02 24.6 µM 1.80E-4 7 2.96E-5 0.04
9 SGTC_1905 st060207 3.92 84.5 µM 2.52E-4 3 4.52E-5 0.18
10 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.89 19.1 µM 2.70E-4 3 4.91E-5 0.06
11 SGTC_787 4152-0075 3.80 138.0 µM 3.64E-4 7 7.11E-5 0.33
12 SGTC_1304 1165-0502 3.74 251.0 µM 4.44E-4 9 9.10E-5 0.29
13 SGTC_881 0833-0569 3.70 170.0 µM 5.07E-4 5 1.07E-4 0.28
14 SGTC_2855 9016525 3.69 58.4 µM 5.32E-4 7 1.14E-4 0.56
15 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.62 14.9 µM 6.49E-4 8 1.45E-4 0.02
16 SGTC_496 calpeptin 3.60 138.0 µM 6.94E-4 7 1.58E-4 0.05
17 SGTC_156 3474-0145 3.59 5.6 µM 7.27E-4 endomembrane recycling 9 1.67E-4 0.07
18 SGTC_2279 7948423 3.53 32.9 µM 8.65E-4 10 2.07E-4 0.12
19 SGTC_2146 5545642 3.48 200.0 µM 0.00102 4 2.54E-4 0.01
20 SGTC_719 2810-4230 3.47 27.3 µM 0.00104 2 2.59E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.78E-16 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.097 1.59E-8 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.097 1.64E-8 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.085 7.51E-7 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.082 1.86E-6 YGR168C_p YGR168C_p hom Putative protein of unknown function; YGR168C is not an essential gene
0.077 7.28E-6 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.076 1.00E-5 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.076 1.07E-5 YDL016C_d YDL016C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
0.075 1.38E-5 YOR224C RPB8 het RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
0.074 1.91E-5 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.073 2.29E-5 YMR275C BUL1 hom Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication
0.073 2.56E-5 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.072 3.17E-5 YLR446W_p YLR446W_p hom Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
0.071 3.67E-5 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.067 1.00E-4 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline