YHR150W / PEX28

Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR150W / PEX28

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.58|P-value:4.86E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.78|P-value:2.41E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.25|P-value:6.23E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.15|P-value:8.77E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.84|P-value:1.03E-6 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.41|P-value:8.45E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.12|P-value:9.60E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.23|P-value:6.64E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.92|P-value:1.43E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.72|P-value:1.84E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-4.07|P-value:8.32E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.90|P-value:5.96E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.28|P-value:5.75E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.73|P-value:2.93E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-7.35|P-value:2.63E-12 ID:SGTC_2047|Compound:4141938|FD-Score:3.14|P-value:8.99E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.17|P-value:8.20E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.16|P-value:2.10E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:4.69E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.31|P-value:5.17E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.54|P-value:5.51E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.34|P-value:4.67E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.43|P-value:3.36E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.46|P-value:7.19E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-6.05|P-value:7.62E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_2704|Compound:st078022|FD-Score:6.12|P-value:1.22E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:-3.51|P-value:6.11E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.16|P-value:8.44E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.38|P-value:4.02E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.89|P-value:8.06E-7 ID:SGTC_2900|Compound:5328528|FD-Score:4.20|P-value:1.76E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.25|P-value:6.35E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.20|P-value:1.82E-5 ID:SGTC_2946|Compound:9065502|FD-Score:4.26|P-value:1.36E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-6.97|P-value:3.16E-11 ID:SGTC_2948|Compound:9070189|FD-Score:5.84|P-value:6.05E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.19|P-value:7.78E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.25|P-value:6.20E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.96|P-value:5.91E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.58|P-value:4.86E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.78|P-value:2.41E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.52|P-value:2.49E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.25|P-value:6.23E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.15|P-value:8.77E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.84|P-value:1.03E-6 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.41|P-value:8.45E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.12|P-value:9.60E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.23|P-value:6.64E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.92|P-value:1.43E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.72|P-value:1.84E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-4.07|P-value:8.32E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.90|P-value:5.96E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.28|P-value:5.75E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.73|P-value:2.93E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-7.35|P-value:2.63E-12 ID:SGTC_2047|Compound:4141938|FD-Score:3.14|P-value:8.99E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.17|P-value:8.20E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.16|P-value:2.10E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.59|P-value:4.69E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.31|P-value:5.17E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.54|P-value:5.51E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.34|P-value:4.67E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.43|P-value:3.36E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.46|P-value:7.19E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-6.05|P-value:7.62E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_2704|Compound:st078022|FD-Score:6.12|P-value:1.22E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:-3.51|P-value:6.11E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.16|P-value:8.44E-4 ID:SGTC_2853|Compound:9015042|FD-Score:3.38|P-value:4.02E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.89|P-value:8.06E-7 ID:SGTC_2900|Compound:5328528|FD-Score:4.20|P-value:1.76E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.25|P-value:6.35E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.20|P-value:1.82E-5 ID:SGTC_2946|Compound:9065502|FD-Score:4.26|P-value:1.36E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-6.97|P-value:3.16E-11 ID:SGTC_2948|Compound:9070189|FD-Score:5.84|P-value:6.05E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.19|P-value:7.78E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.25|P-value:6.20E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.96|P-value:5.91E-7

Top fitness defect scores for YHR150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2704 st078022 6.12 71.1 µM 1.22E-9 1 4.73E-10
2 SGTC_2948 9070189 5.84 9.4 µM 6.05E-9 plasma membrane duress 24 2.63E-9
3 SGTC_3143 9086658 4.96 49.5 µM 5.91E-7 16 3.54E-7
4 SGTC_2887 9044784 4.89 58.4 µM 8.06E-7 fatty acid desaturase (OLE1) 11 4.92E-7
5 SGTC_641 4092-0595 4.84 30.0 µM 1.03E-6 7 6.40E-7
6 SGTC_1569 carminic acid 4.72 40.6 µM 1.84E-6 7 1.18E-6
7 SGTC_2946 9065502 4.26 71.4 µM 1.36E-5 6 1.00E-5
8 SGTC_2900 5328528 4.20 85.3 µM 1.76E-5 Golgi 26 1.31E-5
9 SGTC_2927 9011802 4.20 47.9 µM 1.82E-5 24 1.36E-5
10 SGTC_2063 5246145 4.16 200.0 µM 2.10E-5 19 1.58E-5
11 SGTC_1748 st037455 3.90 53.6 µM 5.96E-5 33 4.78E-5
12 SGTC_2739 tacrine 3.67 100.9 µM 1.45E-4 heme requiring 23 1.23E-4
13 SGTC_1910 st062352 3.64 60.4 µM 1.59E-4 47 1.35E-4
14 SGTC_176 1486-1328 3.63 72.8 µM 1.65E-4 70 1.41E-4
15 SGTC_1030 k029-0042 3.56 36.7 µM 2.13E-4 TSC3-RPN4 41 1.84E-4
16 SGTC_2959 9079155 3.55 11.0 µM 2.24E-4 42 1.94E-4
17 SGTC_295 k015-0027 3.52 31.0 µM 2.49E-4 PDR1 15 2.17E-4
18 SGTC_2628 lathosterol 3.48 100.0 µM 2.80E-4 44 2.46E-4
19 SGTC_2580 diallyl disulphide 3.43 81.4 µM 3.36E-4 34 2.99E-4
20 SGTC_2853 9015042 3.38 58.4 µM 4.02E-4 44 3.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.084 1.00E-6 YNL130C-A_p DGR1_p hom Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
0.083 1.68E-6 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.078 6.00E-6 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
0.078 6.79E-6 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.078 6.95E-6 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.076 1.09E-5 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.072 2.87E-5 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.067 1.08E-4 YCR020C-A MAK31 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
0.066 1.30E-4 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.066 1.41E-4 YBR210W ERV15 hom Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication
0.065 1.49E-4 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.064 2.23E-4 YBL039C URA7 hom Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication
0.064 2.24E-4 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.063 2.71E-4 YBR232C_d YBR232C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.062 2.98E-4 YDR368W YPR1 hom NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication