YHR151C / MTC6

Protein of unknown function; mtc6 is synthetically sick with cdc13-1

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR151C / MTC6

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.92|P-value:2.38E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:4.73|P-value:6.43E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:6.28|P-value:6.46E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.12|P-value:6.00E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.66|P-value:9.42E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:8.13|P-value:3.85E-17 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.06|P-value:1.33E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:4.72|P-value:7.01E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:4.08|P-value:1.55E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.43|P-value:1.86E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.44|P-value:2.24E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.12|P-value:6.07E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.87|P-value:3.19E-7 ID:SGTC_917|Compound:harmaline|FD-Score:4.29|P-value:5.76E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.45|P-value:2.15E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.01|P-value:2.11E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.28|P-value:4.07E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:4.10|P-value:1.40E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.93|P-value:3.01E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.37|P-value:3.49E-11 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.31|P-value:5.19E-6 ID:SGTC_1863|Compound:st057641|FD-Score:3.97|P-value:2.46E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.94|P-value:2.85E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.67|P-value:8.86E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:3.11|P-value:7.64E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.15|P-value:6.63E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.81|P-value:3.99E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.18|P-value:5.81E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.06|P-value:9.17E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.73|P-value:7.10E-5 ID:SGTC_2113|Compound:5491891|FD-Score:5.46|P-value:1.17E-8 ID:SGTC_2122|Compound:5258151|FD-Score:4.67|P-value:8.99E-7 ID:SGTC_2349|Compound:9023730|FD-Score:3.05|P-value:9.24E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.21|P-value:4.37E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:5.55|P-value:6.53E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.09|P-value:1.18E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.15|P-value:6.57E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.33|P-value:3.44E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.17|P-value:5.00E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.42|P-value:3.15E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.86|P-value:3.99E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.72|P-value:7.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.36|P-value:3.03E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.66|P-value:9.41E-7 ID:SGTC_8|Compound:0354-0001|FD-Score:4.92|P-value:2.38E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:4.73|P-value:6.43E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:6.28|P-value:6.46E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.12|P-value:6.00E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.29|P-value:3.92E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.66|P-value:9.42E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:8.13|P-value:3.85E-17 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.06|P-value:1.33E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:4.72|P-value:7.01E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:4.08|P-value:1.55E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.43|P-value:1.86E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.44|P-value:2.24E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.12|P-value:6.07E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.87|P-value:3.19E-7 ID:SGTC_917|Compound:harmaline|FD-Score:4.29|P-value:5.76E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.45|P-value:2.15E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.01|P-value:2.11E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.28|P-value:4.07E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:4.10|P-value:1.40E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.93|P-value:3.01E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.37|P-value:3.49E-11 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.31|P-value:5.19E-6 ID:SGTC_1863|Compound:st057641|FD-Score:3.97|P-value:2.46E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.94|P-value:2.85E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.67|P-value:8.86E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:3.11|P-value:7.64E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.15|P-value:6.63E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.81|P-value:3.99E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.18|P-value:5.81E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.06|P-value:9.17E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.73|P-value:7.10E-5 ID:SGTC_2113|Compound:5491891|FD-Score:5.46|P-value:1.17E-8 ID:SGTC_2122|Compound:5258151|FD-Score:4.67|P-value:8.99E-7 ID:SGTC_2349|Compound:9023730|FD-Score:3.05|P-value:9.24E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.21|P-value:4.37E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:5.55|P-value:6.53E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.09|P-value:1.18E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.15|P-value:6.57E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.33|P-value:3.44E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.17|P-value:5.00E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.42|P-value:3.15E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.86|P-value:3.99E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.72|P-value:7.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.36|P-value:3.03E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.55|P-value:1.43E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.66|P-value:9.41E-7

Top fitness defect scores for YHR151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 8.13 7.5 µM 3.85E-17 ERAD & cell cycle 34 2.12E-16
2 SGTC_1750 st081859 6.37 2.4 µM 3.49E-11 endomembrane recycling 100 9.63E-11
3 SGTC_91 0417-1751 6.28 58.4 µM 6.46E-11 Golgi 13 1.73E-10
4 SGTC_2531 methyl deoxycholate 5.55 70.1 µM 6.53E-9 7 1.39E-8
5 SGTC_2113 5491891 5.46 107.0 µM 1.17E-8 TSC3-RPN4 6 2.42E-8
6 SGTC_8 0354-0001 4.92 70.0 µM 2.38E-7 46 4.27E-7
7 SGTC_892 0929-0076 4.87 29.0 µM 3.19E-7 TRP & mitochondrial translation 16 5.65E-7
8 SGTC_31 0508-1974 4.73 57.2 µM 6.43E-7 11 1.10E-6
9 SGTC_638 3970-0837 4.72 4.1 µM 7.01E-7 19 1.19E-6
10 SGTC_2122 5258151 4.67 111.7 µM 8.99E-7 15 1.51E-6
11 SGTC_3341 9147222 4.66 25.9 µM 9.41E-7 RNA processing & uracil transport 2 1.58E-6
12 SGTC_2777 climbazole 4.42 1.5 µM 3.15E-6 iron homeostasis 32 4.99E-6
13 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 4.31 62.6 µM 5.19E-6 TSC3-RPN4 11 8.04E-6
14 SGTC_917 harmaline 4.29 728.1 nM 5.76E-6 ergosterol biosynthesis 20 8.88E-6
15 SGTC_1692 fluoroquinolonic acid 4.10 71.0 µM 1.40E-5 3 2.07E-5
16 SGTC_667 1498-1044 4.08 59.0 µM 1.55E-5 RPP1 & pyrimidine depletion 14 2.28E-5
17 SGTC_1304 1165-0502 4.01 251.0 µM 2.11E-5 55 3.06E-5
18 SGTC_1863 st057641 3.97 20.1 µM 2.46E-5 12 3.54E-5
19 SGTC_1869 3',7'-dimethoxyflavone 3.94 40.3 µM 2.85E-5 25 4.07E-5
20 SGTC_1730 st033808 3.93 45.1 µM 3.01E-5 30 4.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.298 8.54E-70 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.268 2.25E-56 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.262 9.49E-54 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.254 1.99E-50 YPR153W YPR153W hom Putative protein of unknown function
0.237 6.64E-44 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.152 6.40E-19 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.142 1.40E-16 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.134 7.50E-15 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.128 9.38E-14 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.128 1.04E-13 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.120 2.57E-12 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.120 3.50E-12 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.119 4.35E-12 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.114 3.85E-11 YPR060C ARO7 hom Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
0.112 6.59E-11 YKL039W PTM1 hom Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication