YHR152W / SPO12

Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR152W / SPO12

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.49|P-value:3.05E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.43|P-value:3.70E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.95|P-value:2.32E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.26|P-value:6.38E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.37|P-value:7.97E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.22|P-value:7.72E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.88|P-value:6.81E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.13|P-value:2.48E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.03|P-value:3.44E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.31|P-value:2.34E-10 ID:SGTC_557|Compound:1315-0110|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.58|P-value:3.01E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:5.02|P-value:3.50E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.45|P-value:3.22E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.42|P-value:3.57E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.51|P-value:2.61E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.41|P-value:6.50E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.67|P-value:1.41E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:8.94|P-value:5.62E-19 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.02|P-value:3.59E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.18|P-value:1.77E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.96|P-value:4.52E-5 ID:SGTC_1659|Compound:st012954|FD-Score:4.01|P-value:3.72E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.51|P-value:2.56E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.64|P-value:1.58E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.42|P-value:3.94E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.77|P-value:9.83E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.43|P-value:3.49E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.06|P-value:2.96E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.65|P-value:1.69E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.44|P-value:5.82E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.96|P-value:4.45E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.25|P-value:6.43E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.77|P-value:9.60E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.78|P-value:5.79E-9 ID:SGTC_2625|Compound:euphol|FD-Score:4.59|P-value:2.90E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.93|P-value:5.57E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.70|P-value:1.72E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.22|P-value:7.32E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.43|P-value:3.51E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.85|P-value:6.91E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.87|P-value:6.47E-5 ID:SGTC_2910|Compound:7948405|FD-Score:5.03|P-value:3.28E-7 ID:SGTC_3116|Compound:9124943|FD-Score:3.74|P-value:1.08E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.77|P-value:9.78E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.30|P-value:6.00E-4 ID:SGTC_3157|Compound:9099274|FD-Score:5.29|P-value:8.56E-8 ID:SGTC_3187|Compound:9109394|FD-Score:3.73|P-value:1.13E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.79|P-value:8.96E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.00|P-value:3.89E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.29|P-value:5.70E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.49|P-value:3.05E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.43|P-value:3.70E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.95|P-value:2.32E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.26|P-value:6.38E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.37|P-value:7.97E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.22|P-value:7.72E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.88|P-value:6.81E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.13|P-value:2.48E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.03|P-value:3.44E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.31|P-value:2.34E-10 ID:SGTC_557|Compound:1315-0110|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.58|P-value:3.01E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:5.02|P-value:3.50E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.45|P-value:3.22E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.42|P-value:3.57E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.51|P-value:2.61E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.41|P-value:6.50E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.67|P-value:1.41E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.55|P-value:2.24E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:8.94|P-value:5.62E-19 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.02|P-value:3.59E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.18|P-value:1.77E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.96|P-value:4.52E-5 ID:SGTC_1659|Compound:st012954|FD-Score:4.01|P-value:3.72E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.51|P-value:2.56E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.64|P-value:1.58E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.42|P-value:3.94E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.77|P-value:9.83E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.43|P-value:3.49E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.06|P-value:2.96E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.42|P-value:3.59E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.65|P-value:1.69E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.44|P-value:5.82E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.96|P-value:4.45E-5 ID:SGTC_2517|Compound:totarol|FD-Score:3.25|P-value:6.43E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.77|P-value:9.60E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.78|P-value:5.79E-9 ID:SGTC_2625|Compound:euphol|FD-Score:4.59|P-value:2.90E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.93|P-value:5.57E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.70|P-value:1.72E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.22|P-value:7.32E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.43|P-value:3.51E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.85|P-value:6.91E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.87|P-value:6.47E-5 ID:SGTC_2910|Compound:7948405|FD-Score:5.03|P-value:3.28E-7 ID:SGTC_3116|Compound:9124943|FD-Score:3.74|P-value:1.08E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.77|P-value:9.78E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.30|P-value:6.00E-4 ID:SGTC_3157|Compound:9099274|FD-Score:5.29|P-value:8.56E-8 ID:SGTC_3187|Compound:9109394|FD-Score:3.73|P-value:1.13E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.79|P-value:8.96E-5 ID:SGTC_3317|Compound:9138495|FD-Score:4.00|P-value:3.89E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.29|P-value:5.70E-4

Top fitness defect scores for YHR152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1060 3448-7350 8.94 82.0 µM 5.62E-19 Golgi 8 2.00E-19
2 SGTC_514 4466-0038 6.31 2.6 nM 2.34E-10 cell wall 68 1.42E-10
3 SGTC_2622 2-methoxyxanthone 5.78 59.9 µM 5.79E-9 5 3.82E-9
4 SGTC_3157 9099274 5.29 49.5 µM 8.56E-8 5 6.05E-8
5 SGTC_2910 7948405 5.03 26.0 µM 3.28E-7 plasma membrane duress 13 2.40E-7
6 SGTC_668 1682-0499 5.02 62.6 µM 3.50E-7 9 2.57E-7
7 SGTC_2767 sibutramine 4.70 71.5 µM 1.72E-6 9 1.31E-6
8 SGTC_2625 euphol 4.59 100.0 µM 2.90E-6 21 2.25E-6
9 SGTC_660 4031-1742 4.58 102.0 µM 3.01E-6 redox potentiating 29 2.34E-6
10 SGTC_2506 ethyl hematommate 4.44 54.2 µM 5.82E-6 RPP1 & pyrimidine depletion 8 4.58E-6
11 SGTC_1011 4112-3381 4.41 17.4 µM 6.50E-6 29 5.14E-6
12 SGTC_78 0336-0123 4.37 156.8 µM 7.97E-6 16 6.33E-6
13 SGTC_1485 3909-9022 4.18 254.0 µM 1.77E-5 RPP1 & pyrimidine depletion 4 1.43E-5
14 SGTC_2060 5238662 4.06 140.0 µM 2.96E-5 26 2.43E-5
15 SGTC_272 doxorubicin 4.03 8.1 µM 3.44E-5 anthracycline transcription coupled DNA repair 18 2.83E-5
16 SGTC_1470 k295-0292 4.02 231.0 µM 3.59E-5 11 2.96E-5
17 SGTC_1659 st012954 4.01 42.1 µM 3.72E-5 10 3.07E-5
18 SGTC_3317 9138495 4.00 8.8 µM 3.89E-5 33 3.21E-5
19 SGTC_2510 benzyl isothiocyanate 3.96 8.3 µM 4.45E-5 17 3.69E-5
20 SGTC_1588 farnesol 3.96 29.9 µM 4.52E-5 8 3.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.05E-17 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.117 1.22E-11 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.113 5.51E-11 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.108 3.05E-10 YKL078W DHR2 het Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
0.108 3.10E-10 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
0.107 4.33E-10 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.105 9.97E-10 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.099 1.08E-8 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.098 1.14E-8 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.098 1.38E-8 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.093 7.81E-8 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.090 1.99E-7 YER083C GET2 hom Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
0.089 2.10E-7 YHR204W MNL1 hom Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
0.085 7.12E-7 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.085 7.85E-7 YLR431C ATG23 hom Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p