HIPHOP chemogenomics database
YHR153C / SPO16 
Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YHR153C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.296 | 5.98E-68 | YPR180W | AOS1 | het | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
| 0.225 | 1.79E-39 | YJL171C | YJL171C | hom | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
| 0.215 | 4.33E-36 | YOR152C_p | YOR152C_p | hom | Putative protein of unknown function; YOR152C is not an essential gene |
| 0.213 | 1.43E-35 | YGR022C_d | YGR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
| 0.205 | 1.17E-32 | YNL166C | BNI5 | hom | Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner |
| 0.198 | 1.32E-30 | YNL295W_p | YNL295W_p | hom | Putative protein of unknown function |
| 0.195 | 7.75E-30 | YDR521W_d | YDR521W_d | hom | Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol |
| 0.195 | 8.97E-30 | YDR191W | HST4 | hom | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
| 0.190 | 1.94E-28 | YDR312W | SSF2 | hom | Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication |
| 0.184 | 1.01E-26 | YGR077C | PEX8 | hom | Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p |
| 0.181 | 5.65E-26 | YDL157C_p | YDL157C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.181 | 1.10E-25 | YMR088C | VBA1 | hom | Permease of basic amino acids in the vacuolar membrane |
| 0.173 | 8.99E-24 | YDR530C | APA2 | hom | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication |
| 0.172 | 1.51E-23 | YMR322C_p | SNO4_p | hom | Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation |
| 0.172 | 1.78E-23 | YKL166C | TPK3 | hom | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication |