YHR156C / LIN1

Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR156C / LIN1

Click on Significant Values for Screen Details ID:SGTC_184|Compound:1494-0393|FD-Score:3.41|P-value:3.33E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.21|P-value:6.87E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.65|P-value:1.69E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.30|P-value:4.70E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.42|P-value:2.99E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.31|P-value:4.81E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.31|P-value:4.77E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.17|P-value:7.84E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.26|P-value:5.73E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.44|P-value:2.99E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:5.56|P-value:1.41E-8 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.73|P-value:9.29E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.04|P-value:2.80E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:4.71|P-value:1.28E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.45|P-value:2.86E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.17|P-value:7.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.15|P-value:8.32E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.99|P-value:3.20E-7 ID:SGTC_1744|Compound:st037937|FD-Score:5.10|P-value:1.80E-7 ID:SGTC_1746|Compound:st038117|FD-Score:4.20|P-value:1.36E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.22|P-value:6.69E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.08|P-value:9.87E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.46|P-value:2.81E-4 ID:SGTC_2083|Compound:5306046|FD-Score:5.18|P-value:1.14E-7 ID:SGTC_2094|Compound:5332512|FD-Score:-3.81|P-value:6.72E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.97|P-value:3.78E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.61|P-value:1.55E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-4.48|P-value:3.50E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.14|P-value:8.76E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.10|P-value:9.92E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.76|P-value:8.08E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.57|P-value:2.50E-6 ID:SGTC_2703|Compound:st077852|FD-Score:3.31|P-value:4.88E-4 ID:SGTC_2795|Compound:7780010|FD-Score:7.82|P-value:2.81E-15 ID:SGTC_2800|Compound:7887935|FD-Score:3.92|P-value:4.55E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.34|P-value:7.34E-6 ID:SGTC_2910|Compound:7948405|FD-Score:3.57|P-value:1.84E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.34|P-value:4.82E-8 ID:SGTC_3017|Compound:9080681|FD-Score:3.27|P-value:5.45E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.53|P-value:2.18E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.53|P-value:2.16E-4 ID:SGTC_3177|Compound:9107506|FD-Score:4.33|P-value:7.66E-6 ID:SGTC_3185|Compound:9108267|FD-Score:-3.46|P-value:2.60E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.24|P-value:1.18E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.18|P-value:7.69E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.41|P-value:3.33E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.21|P-value:6.87E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.65|P-value:1.69E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.30|P-value:4.70E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.42|P-value:2.99E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.31|P-value:4.81E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.31|P-value:4.77E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.17|P-value:7.84E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.26|P-value:5.73E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.44|P-value:2.99E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:5.56|P-value:1.41E-8 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.73|P-value:9.29E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.04|P-value:2.80E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:4.71|P-value:1.28E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.45|P-value:2.86E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.17|P-value:7.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.15|P-value:8.32E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.99|P-value:3.20E-7 ID:SGTC_1744|Compound:st037937|FD-Score:5.10|P-value:1.80E-7 ID:SGTC_1746|Compound:st038117|FD-Score:4.20|P-value:1.36E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.22|P-value:6.69E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.08|P-value:9.87E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.46|P-value:2.81E-4 ID:SGTC_2083|Compound:5306046|FD-Score:5.18|P-value:1.14E-7 ID:SGTC_2094|Compound:5332512|FD-Score:-3.81|P-value:6.72E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.97|P-value:3.78E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.61|P-value:1.55E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-4.48|P-value:3.50E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.14|P-value:8.76E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.10|P-value:9.92E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.76|P-value:8.08E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.57|P-value:2.50E-6 ID:SGTC_2703|Compound:st077852|FD-Score:3.31|P-value:4.88E-4 ID:SGTC_2795|Compound:7780010|FD-Score:7.82|P-value:2.81E-15 ID:SGTC_2800|Compound:7887935|FD-Score:3.92|P-value:4.55E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.34|P-value:7.34E-6 ID:SGTC_2910|Compound:7948405|FD-Score:3.57|P-value:1.84E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.34|P-value:4.82E-8 ID:SGTC_3017|Compound:9080681|FD-Score:3.27|P-value:5.45E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.53|P-value:2.18E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.53|P-value:2.16E-4 ID:SGTC_3177|Compound:9107506|FD-Score:4.33|P-value:7.66E-6 ID:SGTC_3185|Compound:9108267|FD-Score:-3.46|P-value:2.60E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.24|P-value:1.18E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.18|P-value:7.69E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.57|P-value:1.85E-4

Top fitness defect scores for YHR156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2795 7780010 7.82 54.5 µM 2.81E-15 1 2.67E-15
2 SGTC_911 3456-4043 5.56 236.0 µM 1.41E-8 mitochondrial processes 6 1.35E-8
3 SGTC_2920 7982904 5.34 15.8 µM 4.82E-8 2 4.62E-8
4 SGTC_2083 5306046 5.18 65.9 µM 1.14E-7 5 1.09E-7
5 SGTC_1744 st037937 5.10 38.9 µM 1.80E-7 4 1.73E-7
6 SGTC_1723 st034307 4.99 2.5 µM 3.20E-7 mitochondrial processes 12 3.08E-7
7 SGTC_942 3253-1115 4.71 227.0 µM 1.28E-6 11 1.23E-6
8 SGTC_313 3474-0040 4.65 5.0 µM 1.69E-6 NEO1-PIK1 47 1.63E-6
9 SGTC_2699 st077704 4.57 54.6 µM 2.50E-6 endomembrane recycling 37 2.41E-6
10 SGTC_2908 7930301 4.34 100.0 µM 7.34E-6 16 7.09E-6
11 SGTC_3177 9107506 4.33 49.5 µM 7.66E-6 ERG2 6 7.39E-6
12 SGTC_3187 9109394 4.24 49.5 µM 1.18E-5 Golgi 15 1.14E-5
13 SGTC_1746 st038117 4.20 42.0 µM 1.36E-5 25 1.32E-5
14 SGTC_940 3232-1287 4.04 54.8 µM 2.80E-5 NEO1 37 2.71E-5
15 SGTC_2243 6634756 3.97 200.0 µM 3.78E-5 19 3.66E-5
16 SGTC_2800 7887935 3.92 81.8 µM 4.55E-5 RPP1 & pyrimidine depletion 35 4.40E-5
17 SGTC_702 1488-0190 3.76 94.0 µM 8.80E-5 amide catabolism 20 8.52E-5
18 SGTC_2467 5474540 3.72 200.0 µM 1.01E-4 22 9.81E-5
19 SGTC_2255 7941087 3.61 197.4 µM 1.55E-4 40 1.51E-4
20 SGTC_1340 1486-1359 3.60 257.0 µM 1.64E-4 33 1.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 1.05E-18 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.111 1.16E-10 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.108 3.10E-10 YHR152W SPO12 hom Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.090 2.02E-7 YGL226C-A OST5 hom Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.087 5.03E-7 YCR005C CIT2 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.083 1.38E-6 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.083 1.41E-6 YOL104C NDJ1 hom Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.082 1.82E-6 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.075 1.25E-5 YNL326C PFA3 hom Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.074 1.65E-5 YPR005C HAL1 hom Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
0.074 1.93E-5 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.073 2.06E-5 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.073 2.08E-5 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.071 4.32E-5 YDL115C IWR1 hom RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
0.070 4.87E-5 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations