YHR157W / REC104

Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR157W / REC104

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.56|P-value:9.94E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.45|P-value:1.54E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.54|P-value:1.29E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.41|P-value:8.81E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.07|P-value:7.71E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.64|P-value:7.14E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:5.64|P-value:2.07E-9 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.67|P-value:7.42E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.20|P-value:4.06E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.19|P-value:3.24E-8 ID:SGTC_380|Compound:3970-0968|FD-Score:-5.52|P-value:5.68E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.73|P-value:4.17E-7 ID:SGTC_393|Compound:acivicin|FD-Score:3.93|P-value:2.05E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.41|P-value:1.86E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.82|P-value:2.46E-7 ID:SGTC_417|Compound:st075190|FD-Score:3.70|P-value:5.52E-5 ID:SGTC_456|Compound:gingerol|FD-Score:2.99|P-value:8.83E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.59|P-value:9.02E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.64|P-value:7.07E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.88|P-value:2.54E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.61|P-value:7.53E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:4.18|P-value:6.58E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.12|P-value:5.51E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.34|P-value:2.99E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:7.08|P-value:8.27E-14 ID:SGTC_880|Compound:0833-0487|FD-Score:3.33|P-value:2.55E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.21|P-value:5.51E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.01|P-value:9.47E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.32|P-value:4.08E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:-5.30|P-value:2.05E-8 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.14|P-value:5.16E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.11|P-value:6.75E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.41|P-value:1.81E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.29|P-value:2.94E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.57|P-value:9.61E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.72|P-value:6.01E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.60|P-value:2.70E-9 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.05|P-value:7.17E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:2.97|P-value:9.36E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:2.98|P-value:9.21E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.80|P-value:4.29E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.01|P-value:8.16E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.57|P-value:9.48E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.35|P-value:2.30E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.46|P-value:1.51E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.07|P-value:6.68E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.97|P-value:1.07E-7 ID:SGTC_2333|Compound:9017922|FD-Score:5.00|P-value:9.56E-8 ID:SGTC_2349|Compound:9023730|FD-Score:4.46|P-value:1.64E-6 ID:SGTC_2351|Compound:9026858|FD-Score:4.18|P-value:6.50E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.48|P-value:1.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.99|P-value:8.86E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.17|P-value:4.64E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.32|P-value:3.04E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.38|P-value:2.47E-6 ID:SGTC_3065|Compound:9113888|FD-Score:-4.16|P-value:8.54E-6 ID:SGTC_3068|Compound:9116768|FD-Score:-3.69|P-value:6.85E-5 ID:SGTC_3110|Compound:9122132|FD-Score:3.12|P-value:5.55E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.48|P-value:1.47E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-3.74|P-value:5.52E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.41|P-value:2.13E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.30|P-value:3.31E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.17|P-value:5.40E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-5.80|P-value:9.70E-10 ID:SGTC_3203|Compound:9113543|FD-Score:-4.86|P-value:2.51E-7 ID:SGTC_3204|Compound:9114183|FD-Score:7.11|P-value:6.90E-14 ID:SGTC_3291|Compound:9121177|FD-Score:5.18|P-value:3.43E-8 ID:SGTC_3295|Compound:9122362|FD-Score:3.03|P-value:7.73E-4 ID:SGTC_3296|Compound:9122258|FD-Score:5.58|P-value:3.01E-9 ID:SGTC_10|Compound:0279-0212|FD-Score:3.56|P-value:9.94E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.45|P-value:1.54E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.54|P-value:1.29E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.41|P-value:8.81E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.07|P-value:7.71E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.64|P-value:7.14E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:5.64|P-value:2.07E-9 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.67|P-value:7.42E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.20|P-value:4.06E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.19|P-value:3.24E-8 ID:SGTC_380|Compound:3970-0968|FD-Score:-5.52|P-value:5.68E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.73|P-value:4.17E-7 ID:SGTC_393|Compound:acivicin|FD-Score:3.93|P-value:2.05E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.41|P-value:1.86E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.82|P-value:2.46E-7 ID:SGTC_417|Compound:st075190|FD-Score:3.70|P-value:5.52E-5 ID:SGTC_456|Compound:gingerol|FD-Score:2.99|P-value:8.83E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.59|P-value:9.02E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:3.64|P-value:7.07E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:3.88|P-value:2.54E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.61|P-value:7.53E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:4.18|P-value:6.58E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.12|P-value:5.51E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.34|P-value:2.99E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:7.08|P-value:8.27E-14 ID:SGTC_880|Compound:0833-0487|FD-Score:3.33|P-value:2.55E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.21|P-value:5.51E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.01|P-value:9.47E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.32|P-value:4.08E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:-5.30|P-value:2.05E-8 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.14|P-value:5.16E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.11|P-value:6.75E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.41|P-value:1.81E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.29|P-value:2.94E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.57|P-value:9.61E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.72|P-value:6.01E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:5.60|P-value:2.70E-9 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.05|P-value:7.17E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:2.97|P-value:9.36E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:2.98|P-value:9.21E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.80|P-value:4.29E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.01|P-value:8.16E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.57|P-value:9.48E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.35|P-value:2.30E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.46|P-value:1.51E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.07|P-value:6.68E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.97|P-value:1.07E-7 ID:SGTC_2333|Compound:9017922|FD-Score:5.00|P-value:9.56E-8 ID:SGTC_2349|Compound:9023730|FD-Score:4.46|P-value:1.64E-6 ID:SGTC_2351|Compound:9026858|FD-Score:4.18|P-value:6.50E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.48|P-value:1.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.99|P-value:8.86E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.17|P-value:4.64E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.32|P-value:3.04E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.38|P-value:2.47E-6 ID:SGTC_3065|Compound:9113888|FD-Score:-4.16|P-value:8.54E-6 ID:SGTC_3068|Compound:9116768|FD-Score:-3.69|P-value:6.85E-5 ID:SGTC_3110|Compound:9122132|FD-Score:3.12|P-value:5.55E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.48|P-value:1.47E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-3.74|P-value:5.52E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.41|P-value:2.13E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.30|P-value:3.31E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.17|P-value:5.40E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-5.80|P-value:9.70E-10 ID:SGTC_3203|Compound:9113543|FD-Score:-4.86|P-value:2.51E-7 ID:SGTC_3204|Compound:9114183|FD-Score:7.11|P-value:6.90E-14 ID:SGTC_3291|Compound:9121177|FD-Score:5.18|P-value:3.43E-8 ID:SGTC_3295|Compound:9122362|FD-Score:3.03|P-value:7.73E-4 ID:SGTC_3296|Compound:9122258|FD-Score:5.58|P-value:3.01E-9

Top fitness defect scores for YHR157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3204 9114183 7.11 49.5 µM 6.90E-14 4 6.01E-13
2 SGTC_828 2074-0507 7.08 139.0 µM 8.27E-14 RPP1 & pyrimidine depletion 7 7.10E-13
3 SGTC_211 3455-0679 5.64 143.5 µM 2.07E-9 3 8.43E-9
4 SGTC_1207 2099-0101 5.60 141.0 µM 2.70E-9 2 1.08E-8
5 SGTC_3296 9122258 5.58 64.0 µM 3.01E-9 redox potentiating 9 1.19E-8
6 SGTC_168 3970-0862 5.41 530.5 µM 8.81E-9 60 3.23E-8
7 SGTC_379 3970-0972 5.19 5.9 µM 3.24E-8 tubulin folding & SWR complex 9 1.08E-7
8 SGTC_3291 9121177 5.18 71.4 µM 3.43E-8 3 1.14E-7
9 SGTC_2333 9017922 5.00 200.0 µM 9.56E-8 13 2.94E-7
10 SGTC_2325 6158266 4.97 200.0 µM 1.07E-7 10 3.27E-7
11 SGTC_407 eburnamonine 4.82 100.0 µM 2.46E-7 6 7.04E-7
12 SGTC_390 dec-rvkr-cmk 4.73 16.7 µM 4.17E-7 calcium & mitochondrial duress 13 1.15E-6
13 SGTC_530 4358-1714 4.61 28.0 µM 7.53E-7 27 1.99E-6
14 SGTC_1815 st051655 4.57 58.2 µM 9.48E-7 TSC3-RPN4 6 2.46E-6
15 SGTC_3132 9126706 4.48 49.5 µM 1.47E-6 10 3.70E-6
16 SGTC_2349 9023730 4.46 187.1 µM 1.64E-6 13 4.09E-6
17 SGTC_3143 9086658 4.41 49.5 µM 2.13E-6 30 5.20E-6
18 SGTC_2940 9060638 4.38 45.9 µM 2.47E-6 amide catabolism 16 5.96E-6
19 SGTC_708 3448-5400 4.34 146.0 µM 2.99E-6 35 7.14E-6
20 SGTC_908 3448-7491 4.21 47.7 µM 5.51E-6 mitochondrial stress 106 1.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 9.22E-8 YHR028C DAP2 hom Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
0.087 4.00E-7 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.087 4.95E-7 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.084 1.24E-6 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.081 2.38E-6 YHR202W_p YHR202W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
0.079 4.77E-6 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.078 5.72E-6 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.078 6.76E-6 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.076 1.09E-5 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.075 1.32E-5 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.075 1.49E-5 YBR282W MRPL27 hom Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP
0.073 2.31E-5 YHR011W DIA4 hom Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
0.073 2.43E-5 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.072 3.33E-5 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.072 3.29E-5 YBL090W MRP21 hom Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences