YHR160C / PEX18

Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR160C / PEX18

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:9.32|P-value:3.06E-20 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.16|P-value:8.80E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.21|P-value:7.52E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:4.11|P-value:2.87E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.24|P-value:7.80E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.31|P-value:5.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.22|P-value:8.34E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.28|P-value:5.85E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.34|P-value:5.54E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.36|P-value:5.14E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.36|P-value:5.23E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.10|P-value:3.03E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.56|P-value:2.51E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.39|P-value:4.64E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.57|P-value:3.91E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.37|P-value:4.34E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.15|P-value:2.51E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.13|P-value:2.28E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.18|P-value:9.62E-4 ID:SGTC_1547|Compound:harmine|FD-Score:4.14|P-value:2.62E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:5.17|P-value:2.14E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.19|P-value:9.25E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.88|P-value:7.36E-5 ID:SGTC_1672|Compound:st016598|FD-Score:7.53|P-value:7.61E-14 ID:SGTC_1678|Compound:st019265|FD-Score:3.45|P-value:3.82E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.64|P-value:1.88E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.38|P-value:4.84E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.41|P-value:3.72E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.53|P-value:2.39E-4 ID:SGTC_1762|Compound:st045503|FD-Score:5.44|P-value:5.05E-8 ID:SGTC_1763|Compound:st044482|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.27|P-value:7.01E-4 ID:SGTC_1825|Compound:st052143|FD-Score:6.24|P-value:4.80E-10 ID:SGTC_1868|Compound:st057644|FD-Score:4.10|P-value:3.06E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-5.31|P-value:8.10E-8 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.27|P-value:7.06E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.02|P-value:4.20E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-3.17|P-value:8.40E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.54|P-value:2.71E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.63|P-value:1.95E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.35|P-value:1.05E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.18|P-value:8.30E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.59|P-value:1.92E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.24|P-value:7.70E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.27|P-value:7.11E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.30|P-value:6.46E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.92|P-value:7.37E-7 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.32|P-value:6.03E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.41|P-value:7.92E-6 ID:SGTC_2804|Compound:7954240|FD-Score:-4.03|P-value:3.45E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.34|P-value:5.56E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.30|P-value:1.31E-5 ID:SGTC_2927|Compound:9011802|FD-Score:4.24|P-value:1.70E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-4.17|P-value:1.85E-5 ID:SGTC_3114|Compound:9122766|FD-Score:4.01|P-value:4.45E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.28|P-value:6.73E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.22|P-value:8.36E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.19|P-value:9.25E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.12|P-value:9.90E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.88|P-value:7.38E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:9.32|P-value:3.06E-20 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.16|P-value:8.80E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.21|P-value:7.52E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:4.11|P-value:2.87E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.24|P-value:7.80E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.31|P-value:5.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.22|P-value:8.34E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.28|P-value:5.85E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.34|P-value:5.54E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.36|P-value:5.14E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.36|P-value:5.23E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.10|P-value:3.03E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.56|P-value:2.51E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.39|P-value:4.64E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.57|P-value:3.91E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.37|P-value:4.34E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.15|P-value:2.51E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.13|P-value:2.28E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.18|P-value:9.62E-4 ID:SGTC_1547|Compound:harmine|FD-Score:4.14|P-value:2.62E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:5.17|P-value:2.14E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.19|P-value:9.25E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.88|P-value:7.36E-5 ID:SGTC_1672|Compound:st016598|FD-Score:7.53|P-value:7.61E-14 ID:SGTC_1678|Compound:st019265|FD-Score:3.45|P-value:3.82E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.64|P-value:1.88E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.38|P-value:4.84E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.41|P-value:3.72E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.53|P-value:2.39E-4 ID:SGTC_1762|Compound:st045503|FD-Score:5.44|P-value:5.05E-8 ID:SGTC_1763|Compound:st044482|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.27|P-value:7.01E-4 ID:SGTC_1825|Compound:st052143|FD-Score:6.24|P-value:4.80E-10 ID:SGTC_1868|Compound:st057644|FD-Score:4.10|P-value:3.06E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-5.31|P-value:8.10E-8 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.27|P-value:7.06E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.02|P-value:4.20E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-3.17|P-value:8.40E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.54|P-value:2.71E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.63|P-value:1.95E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.35|P-value:1.05E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.18|P-value:8.30E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.59|P-value:1.92E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.24|P-value:7.70E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.27|P-value:7.11E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.30|P-value:6.46E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.92|P-value:7.37E-7 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.32|P-value:6.03E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.41|P-value:7.92E-6 ID:SGTC_2804|Compound:7954240|FD-Score:-4.03|P-value:3.45E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.34|P-value:5.56E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.30|P-value:1.31E-5 ID:SGTC_2927|Compound:9011802|FD-Score:4.24|P-value:1.70E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-4.17|P-value:1.85E-5 ID:SGTC_3114|Compound:9122766|FD-Score:4.01|P-value:4.45E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.28|P-value:6.73E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.22|P-value:8.36E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.19|P-value:9.25E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.12|P-value:9.90E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.88|P-value:7.38E-5

Top fitness defect scores for YHR160C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_95 0471-0001 9.32 561.1 µM 3.06E-20 1 5.71E-21
2 SGTC_1672 st016598 7.53 6.5 µM 7.61E-14 endomembrane recycling 20 2.45E-14
3 SGTC_1825 st052143 6.24 62.6 µM 4.80E-10 3 2.14E-10
4 SGTC_1762 st045503 5.44 25.5 µM 5.05E-8 9 2.68E-8
5 SGTC_1581 himbacine 5.17 57.9 µM 2.14E-7 Golgi 28 1.20E-7
6 SGTC_2687 chenodiol 4.92 100.0 µM 7.37E-7 8 4.33E-7
7 SGTC_1137 ixabepilone 4.57 100.0 µM 3.91E-6 15 2.45E-6
8 SGTC_2795 7780010 4.41 54.5 µM 7.92E-6 17 5.09E-6
9 SGTC_2476 5806916 4.35 10.5 µM 1.05E-5 10 6.85E-6
10 SGTC_2911 7942208 4.30 15.6 µM 1.31E-5 mitochondrial response to ROS 15 8.60E-6
11 SGTC_2927 9011802 4.24 47.9 µM 1.70E-5 21 1.13E-5
12 SGTC_1446 4239-0190 4.15 62.0 µM 2.51E-5 32 1.69E-5
13 SGTC_1547 harmine 4.14 94.2 µM 2.62E-5 ergosterol biosynthesis 36 1.77E-5
14 SGTC_192 3455-0609 4.11 60.9 µM 2.87E-5 10 1.94E-5
15 SGTC_711 k292-0785 4.10 179.0 µM 3.03E-5 DNA intercalators 18 2.05E-5
16 SGTC_1868 st057644 4.10 42.7 µM 3.06E-5 31 2.07E-5
17 SGTC_2191 5911152 4.02 200.0 µM 4.20E-5 13 2.88E-5
18 SGTC_3114 9122766 4.01 49.5 µM 4.45E-5 14 3.05E-5
19 SGTC_1659 st012954 3.88 42.1 µM 7.36E-5 13 5.15E-5
20 SGTC_3354 9151612 3.88 71.4 µM 7.38E-5 10 5.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.65E-10 YLR342W-A_p YLR342W-A_p hom Putative protein of unknown function
0.095 3.16E-8 YMR187C_p YMR187C_p hom Putative protein of unknown function; YMR187C is not an essential gene
0.079 5.25E-6 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.076 1.18E-5 YDR368W YPR1 hom NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication
0.075 1.26E-5 YPR156C TPO3 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication
0.074 1.91E-5 YKL162C-A_d YKL162C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.23E-5 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.071 3.58E-5 YKL047W_p ANR2_p hom Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.071 3.91E-5 YPL253C VIK1 hom Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
0.071 4.21E-5 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.067 9.13E-5 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.067 9.65E-5 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.066 1.28E-4 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.066 1.33E-4 YJR051W OSM1 hom Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
0.065 1.84E-4 YIL071C PCI8 hom Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain