YHR161C / YAP1801

Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR161C / YAP1801

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.41|P-value:3.68E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:5.71|P-value:8.26E-9 ID:SGTC_135|Compound:0933-0004|FD-Score:3.22|P-value:7.29E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.26|P-value:6.37E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.19|P-value:8.07E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.16|P-value:8.81E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.38|P-value:4.11E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.78|P-value:9.34E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.98|P-value:4.15E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.32|P-value:7.16E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:4.33|P-value:9.23E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:4.79|P-value:1.07E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:3.15|P-value:9.15E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.14|P-value:9.37E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.84|P-value:7.25E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.14|P-value:9.61E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.76|P-value:9.80E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.61|P-value:1.82E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.22|P-value:1.20E-7 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.23|P-value:7.07E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:6.34|P-value:1.81E-10 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.30|P-value:5.45E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.66|P-value:2.07E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.29|P-value:5.60E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.20|P-value:7.82E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.90|P-value:6.36E-7 ID:SGTC_1706|Compound:st031321|FD-Score:4.86|P-value:7.74E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.51|P-value:4.01E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.36|P-value:4.38E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.19|P-value:7.87E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.13|P-value:9.92E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.49|P-value:2.81E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.44|P-value:3.28E-4 ID:SGTC_2025|Compound:5147754|FD-Score:4.23|P-value:1.41E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.93|P-value:5.47E-7 ID:SGTC_2142|Compound:5622915|FD-Score:3.26|P-value:6.24E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.27|P-value:6.09E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.79|P-value:1.09E-6 ID:SGTC_2297|Compound:7971671|FD-Score:3.79|P-value:8.80E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.40|P-value:3.90E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.25|P-value:6.48E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.19|P-value:8.12E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:6.49|P-value:6.97E-11 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.57|P-value:2.04E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.16|P-value:8.90E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.26|P-value:6.32E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.36|P-value:4.36E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.64|P-value:1.61E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.97|P-value:4.26E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.00|P-value:3.84E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.76|P-value:9.79E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.17|P-value:1.82E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.59|P-value:2.87E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:3.41|P-value:3.68E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:5.71|P-value:8.26E-9 ID:SGTC_135|Compound:0933-0004|FD-Score:3.22|P-value:7.29E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.26|P-value:6.37E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.19|P-value:8.07E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.16|P-value:8.81E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.26|P-value:6.34E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.38|P-value:4.11E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.78|P-value:9.34E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.98|P-value:4.15E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.32|P-value:7.16E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:4.33|P-value:9.23E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:4.79|P-value:1.07E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:3.15|P-value:9.15E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.14|P-value:9.37E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.84|P-value:7.25E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.14|P-value:9.61E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.76|P-value:9.80E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.61|P-value:1.82E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.22|P-value:1.20E-7 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.23|P-value:7.07E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:6.34|P-value:1.81E-10 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.30|P-value:5.45E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.53|P-value:2.41E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.66|P-value:2.07E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.29|P-value:5.60E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.20|P-value:7.82E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.90|P-value:6.36E-7 ID:SGTC_1706|Compound:st031321|FD-Score:4.86|P-value:7.74E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.51|P-value:4.01E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.36|P-value:4.38E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.19|P-value:7.87E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.13|P-value:9.92E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.49|P-value:2.81E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.44|P-value:3.28E-4 ID:SGTC_2025|Compound:5147754|FD-Score:4.23|P-value:1.41E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.93|P-value:5.47E-7 ID:SGTC_2142|Compound:5622915|FD-Score:3.26|P-value:6.24E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.27|P-value:6.09E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.79|P-value:1.09E-6 ID:SGTC_2297|Compound:7971671|FD-Score:3.79|P-value:8.80E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.40|P-value:3.90E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.25|P-value:6.48E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.19|P-value:8.12E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:6.49|P-value:6.97E-11 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.57|P-value:2.04E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.16|P-value:8.90E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.26|P-value:6.32E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.36|P-value:4.36E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.64|P-value:1.61E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.97|P-value:4.26E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.00|P-value:3.84E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.76|P-value:9.79E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.17|P-value:1.82E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.59|P-value:2.87E-6

Top fitness defect scores for YHR161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2528 xanthyletin 6.49 44.8 µM 6.97E-11 3 4.36E-11
2 SGTC_1355 1499-0035 6.34 1.7 µM 1.81E-10 2 1.16E-10
3 SGTC_105 0111-0055 5.71 734.8 µM 8.26E-9 1 5.74E-9
4 SGTC_1266 0828-0227 5.22 32.9 µM 1.20E-7 5 8.81E-8
5 SGTC_2121 5257820 4.93 149.6 µM 5.47E-7 2 4.16E-7
6 SGTC_1682 st012968 4.90 530.0 nM 6.36E-7 5 4.85E-7
7 SGTC_1706 st031321 4.86 10.0 µM 7.74E-7 TSC3-RPN4 7 5.93E-7
8 SGTC_963 1269-2853 4.79 151.0 µM 1.07E-6 16 8.28E-7
9 SGTC_2261 9010538 4.79 184.7 µM 1.09E-6 8 8.44E-7
10 SGTC_1491 4138-0063 4.66 26.5 µM 2.07E-6 2 1.62E-6
11 SGTC_3193 9111931 4.59 49.5 µM 2.87E-6 10 2.26E-6
12 SGTC_1809 st050081 4.51 57.6 µM 4.01E-6 11 3.19E-6
13 SGTC_948 3448-0295 4.33 75.3 µM 9.23E-6 18 7.47E-6
14 SGTC_2025 5147754 4.23 141.0 µM 1.41E-5 5 1.15E-5
15 SGTC_3080 9117754 4.17 49.5 µM 1.82E-5 14 1.49E-5
16 SGTC_2833 9001315 4.00 45.5 µM 3.84E-5 amide catabolism 53 3.20E-5
17 SGTC_782 0083-0095 3.98 30.5 µM 4.15E-5 24 3.47E-5
18 SGTC_2822 7994718 3.97 71.4 µM 4.26E-5 16 3.56E-5
19 SGTC_1137 ixabepilone 3.84 100.0 µM 7.25E-5 27 6.13E-5
20 SGTC_2297 7971671 3.79 152.3 µM 8.80E-5 RNA processing & uracil transport 31 7.47E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.93E-11 YOR228C YOR228C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.075 1.33E-5 YPR068C HOS1 hom Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.074 1.75E-5 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.070 4.93E-5 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.070 5.50E-5 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.068 8.82E-5 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.067 1.03E-4 YPL016W SWI1 het Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
0.066 1.30E-4 YJL127C SPT10 hom Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
0.065 1.59E-4 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.065 1.61E-4 YJR047C ANB1 hom Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication
0.064 2.03E-4 YKR083C DAD2 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.063 2.40E-4 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.063 2.42E-4 YOR178C GAC1 hom Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
0.063 2.62E-4 YPR106W ISR1 hom Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
0.062 2.99E-4 YBR295W PCA1 hom Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function