YHR162W / MPC2

Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR162W / MPC2

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:5.40|P-value:5.29E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:5.05|P-value:3.21E-7 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.25|P-value:8.45E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.77|P-value:1.00E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.54|P-value:3.08E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.56|P-value:2.85E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.74|P-value:7.84E-9 ID:SGTC_607|Compound:4491-0986|FD-Score:3.97|P-value:4.41E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.63|P-value:1.68E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.66|P-value:1.95E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.12|P-value:2.37E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.80|P-value:8.74E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.56|P-value:2.87E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.80|P-value:8.78E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.69|P-value:1.32E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.78|P-value:9.37E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.18|P-value:8.33E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.38|P-value:5.84E-8 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.25|P-value:6.57E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.00|P-value:5.40E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.81|P-value:1.09E-6 ID:SGTC_1774|Compound:st048371|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.78|P-value:1.23E-6 ID:SGTC_1871|Compound:st057448|FD-Score:-4.02|P-value:4.90E-5 ID:SGTC_1911|Compound:st060208|FD-Score:5.55|P-value:2.37E-8 ID:SGTC_1954|Compound:st077032|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.93|P-value:5.18E-5 ID:SGTC_2165|Compound:5727197|FD-Score:7.16|P-value:9.55E-13 ID:SGTC_2291|Compound:7917025|FD-Score:3.71|P-value:1.23E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.51|P-value:2.60E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.60|P-value:1.87E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.55|P-value:3.00E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.31|P-value:1.27E-7 ID:SGTC_2448|Compound:5185112|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.20|P-value:7.65E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.17|P-value:8.44E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.78|P-value:9.60E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.55|P-value:2.28E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.20|P-value:7.78E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.35|P-value:5.95E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.24|P-value:1.43E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.36|P-value:4.48E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.78|P-value:1.24E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.39|P-value:7.34E-6 ID:SGTC_3056|Compound:9094900|FD-Score:-4.52|P-value:5.93E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.98|P-value:4.30E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-3.30|P-value:7.11E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.39|P-value:5.26E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.31|P-value:5.30E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:5.40|P-value:5.29E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:5.05|P-value:3.21E-7 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.25|P-value:8.45E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.77|P-value:1.00E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.54|P-value:3.08E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.56|P-value:2.85E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.74|P-value:7.84E-9 ID:SGTC_607|Compound:4491-0986|FD-Score:3.97|P-value:4.41E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.63|P-value:1.68E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.66|P-value:1.95E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.12|P-value:2.37E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.80|P-value:8.74E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.56|P-value:2.87E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.80|P-value:8.78E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.69|P-value:1.32E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.78|P-value:9.37E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.18|P-value:8.33E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.38|P-value:5.84E-8 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.25|P-value:6.57E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.00|P-value:5.40E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.81|P-value:1.09E-6 ID:SGTC_1774|Compound:st048371|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.78|P-value:1.23E-6 ID:SGTC_1871|Compound:st057448|FD-Score:-4.02|P-value:4.90E-5 ID:SGTC_1911|Compound:st060208|FD-Score:5.55|P-value:2.37E-8 ID:SGTC_1954|Compound:st077032|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.93|P-value:5.18E-5 ID:SGTC_2165|Compound:5727197|FD-Score:7.16|P-value:9.55E-13 ID:SGTC_2291|Compound:7917025|FD-Score:3.71|P-value:1.23E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.51|P-value:2.60E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.60|P-value:1.87E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.55|P-value:3.00E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.31|P-value:1.27E-7 ID:SGTC_2448|Compound:5185112|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.20|P-value:7.65E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.17|P-value:8.44E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.78|P-value:9.60E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.55|P-value:2.28E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.20|P-value:7.78E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.35|P-value:5.95E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.24|P-value:1.43E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.36|P-value:4.48E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.78|P-value:1.24E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.39|P-value:7.34E-6 ID:SGTC_3056|Compound:9094900|FD-Score:-4.52|P-value:5.93E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.98|P-value:4.30E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-3.30|P-value:7.11E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.39|P-value:5.26E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.31|P-value:5.30E-4

Top fitness defect scores for YHR162W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2165 5727197 7.16 32.1 µM 9.55E-13 4 3.95E-13
2 SGTC_403 arphamenine a 5.74 50.0 µM 7.84E-9 60S ribosome export 4 4.60E-9
3 SGTC_1911 st060208 5.55 74.3 µM 2.37E-8 7 1.45E-8
4 SGTC_47 0149-0135 5.40 24.2 µM 5.29E-8 TSC3-RPN4 5 3.34E-8
5 SGTC_1425 4048-4433 5.38 7.3 µM 5.84E-8 copper-dependent oxidative stress 16 3.70E-8
6 SGTC_68 0986-0284 5.05 82.8 µM 3.21E-7 30 2.17E-7
7 SGTC_1681 tripelennamine 4.81 100.0 µM 1.09E-6 10 7.69E-7
8 SGTC_1812 st052057 4.78 4.3 µM 1.23E-6 calcium & mitochondrial duress 10 8.69E-7
9 SGTC_2969 9091408 4.39 28.7 µM 7.34E-6 17 5.55E-6
10 SGTC_2826 7992541 4.24 19.5 µM 1.43E-5 17 1.11E-5
11 SGTC_977 1348-1378 4.12 135.0 µM 2.37E-5 21 1.87E-5
12 SGTC_3060 1327-0027 3.98 12.5 µM 4.30E-5 36 3.46E-5
13 SGTC_607 4491-0986 3.97 66.8 µM 4.41E-5 heme requiring 28 3.56E-5
14 SGTC_2131 toluylene red 3.93 5.3 µM 5.18E-5 60S ribosome export 24 4.20E-5
15 SGTC_982 1491-0518 3.80 27.5 µM 8.74E-5 14 7.21E-5
16 SGTC_1174 0739-0097 3.80 51.1 µM 8.78E-5 redox potentiating 40 7.25E-5
17 SGTC_1233 0325-0408 3.78 14.2 µM 9.37E-5 23 7.75E-5
18 SGTC_2561 acetosyringone 3.78 100.0 µM 9.60E-5 32 7.94E-5
19 SGTC_307 1501-1223 3.77 22.3 µM 1.00E-4 16 8.31E-5
20 SGTC_2291 7917025 3.71 104.3 µM 1.23E-4 iron homeostasis 61 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.30E-10 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.096 2.22E-8 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.092 8.70E-8 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.092 9.19E-8 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.088 3.72E-7 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.084 1.19E-6 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.079 4.48E-6 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.079 5.17E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.078 6.13E-6 YPL141C FRK1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication
0.075 1.39E-5 YBR239C_p ERT1_p hom Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
0.073 2.42E-5 YAL007C ERP2 hom Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
0.073 2.47E-5 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.072 2.78E-5 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.069 7.12E-5 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.067 9.56E-5 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data