YHR163W / SOL3

6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR163W / SOL3

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.20|P-value:5.19E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.62|P-value:1.05E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:8.70|P-value:2.15E-19 ID:SGTC_210|Compound:3551-0445|FD-Score:12.40|P-value:1.24E-37 ID:SGTC_211|Compound:3455-0679|FD-Score:10.80|P-value:7.32E-29 ID:SGTC_223|Compound:busulfan|FD-Score:5.50|P-value:8.47E-9 ID:SGTC_224|Compound:benfluorex|FD-Score:3.19|P-value:5.34E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.84|P-value:4.06E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.05|P-value:1.10E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:3.59|P-value:1.19E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:7.33|P-value:2.81E-14 ID:SGTC_394|Compound:menadione|FD-Score:-3.31|P-value:3.32E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.93|P-value:2.71E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:-4.13|P-value:1.12E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-5.64|P-value:3.51E-9 ID:SGTC_459|Compound:nigericin|FD-Score:-4.49|P-value:1.96E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.93|P-value:2.68E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.47|P-value:1.87E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.12|P-value:6.96E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.04|P-value:7.88E-17 ID:SGTC_844|Compound:0330-0132|FD-Score:-5.68|P-value:2.75E-9 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.32|P-value:3.22E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.58|P-value:1.22E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.62|P-value:1.03E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.36|P-value:2.90E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.51|P-value:1.59E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.27|P-value:5.94E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:5.40|P-value:1.57E-8 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.04|P-value:9.11E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.53|P-value:1.72E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.10|P-value:7.43E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.95|P-value:2.60E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.20|P-value:5.13E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:8.16|P-value:2.82E-17 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.30|P-value:3.56E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.85|P-value:3.89E-5 ID:SGTC_1612|Compound:st002233|FD-Score:3.70|P-value:7.35E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.09|P-value:1.39E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.51|P-value:1.23E-11 ID:SGTC_1724|Compound:st037281|FD-Score:3.15|P-value:6.22E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.26|P-value:3.43E-8 ID:SGTC_1749|Compound:st037932|FD-Score:4.10|P-value:1.30E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.72|P-value:6.85E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.31|P-value:3.44E-4 ID:SGTC_1827|Compound:berberine|FD-Score:5.22|P-value:4.41E-8 ID:SGTC_1840|Compound:st055363|FD-Score:3.25|P-value:4.31E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.48|P-value:1.80E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.03|P-value:9.49E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.13|P-value:6.64E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.24|P-value:4.47E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.30|P-value:3.62E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.73|P-value:6.21E-7 ID:SGTC_2465|Compound:5809242|FD-Score:3.25|P-value:4.33E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.05|P-value:8.94E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.28|P-value:3.84E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.80|P-value:1.32E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:4.44|P-value:2.62E-6 ID:SGTC_2801|Compound:7907800|FD-Score:-3.47|P-value:1.80E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.90|P-value:3.15E-5 ID:SGTC_2949|Compound:9072542|FD-Score:5.68|P-value:2.91E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.05|P-value:8.77E-4 ID:SGTC_3123|Compound:9126162|FD-Score:7.33|P-value:2.85E-14 ID:SGTC_3124|Compound:9127567|FD-Score:-4.67|P-value:8.15E-7 ID:SGTC_3143|Compound:9086658|FD-Score:4.32|P-value:4.73E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.20|P-value:5.19E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.62|P-value:1.05E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:8.70|P-value:2.15E-19 ID:SGTC_210|Compound:3551-0445|FD-Score:12.40|P-value:1.24E-37 ID:SGTC_211|Compound:3455-0679|FD-Score:10.80|P-value:7.32E-29 ID:SGTC_223|Compound:busulfan|FD-Score:5.50|P-value:8.47E-9 ID:SGTC_224|Compound:benfluorex|FD-Score:3.19|P-value:5.34E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.84|P-value:4.06E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.05|P-value:1.10E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:3.59|P-value:1.19E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:7.33|P-value:2.81E-14 ID:SGTC_394|Compound:menadione|FD-Score:-3.31|P-value:3.32E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.93|P-value:2.71E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:-4.13|P-value:1.12E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-5.64|P-value:3.51E-9 ID:SGTC_459|Compound:nigericin|FD-Score:-4.49|P-value:1.96E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.93|P-value:2.68E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.47|P-value:1.87E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.12|P-value:6.96E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.04|P-value:7.88E-17 ID:SGTC_844|Compound:0330-0132|FD-Score:-5.68|P-value:2.75E-9 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.32|P-value:3.22E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.58|P-value:1.22E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.62|P-value:1.03E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.36|P-value:2.90E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.51|P-value:1.59E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.27|P-value:5.94E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:5.40|P-value:1.57E-8 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.04|P-value:9.11E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.53|P-value:1.72E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.10|P-value:7.43E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.95|P-value:2.60E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.20|P-value:5.13E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:8.16|P-value:2.82E-17 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.30|P-value:3.56E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.85|P-value:3.89E-5 ID:SGTC_1612|Compound:st002233|FD-Score:3.70|P-value:7.35E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.09|P-value:1.39E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.51|P-value:1.23E-11 ID:SGTC_1724|Compound:st037281|FD-Score:3.15|P-value:6.22E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.26|P-value:3.43E-8 ID:SGTC_1749|Compound:st037932|FD-Score:4.10|P-value:1.30E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.72|P-value:6.85E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.31|P-value:3.44E-4 ID:SGTC_1827|Compound:berberine|FD-Score:5.22|P-value:4.41E-8 ID:SGTC_1840|Compound:st055363|FD-Score:3.25|P-value:4.31E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.48|P-value:1.80E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.03|P-value:9.49E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.13|P-value:6.64E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.24|P-value:4.47E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.30|P-value:3.62E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.73|P-value:6.21E-7 ID:SGTC_2465|Compound:5809242|FD-Score:3.25|P-value:4.33E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.05|P-value:8.94E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.28|P-value:3.84E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.80|P-value:1.32E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:4.44|P-value:2.62E-6 ID:SGTC_2801|Compound:7907800|FD-Score:-3.47|P-value:1.80E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.90|P-value:3.15E-5 ID:SGTC_2949|Compound:9072542|FD-Score:5.68|P-value:2.91E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.05|P-value:8.77E-4 ID:SGTC_3123|Compound:9126162|FD-Score:7.33|P-value:2.85E-14 ID:SGTC_3124|Compound:9127567|FD-Score:-4.67|P-value:8.15E-7 ID:SGTC_3143|Compound:9086658|FD-Score:4.32|P-value:4.73E-6

Top fitness defect scores for YHR163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_210 3551-0445 12.40 56.8 µM 1.24E-37 12 7.50E-36
2 SGTC_211 3455-0679 10.80 143.5 µM 7.32E-29 1 1.61E-27
3 SGTC_209 4077-0173 8.70 175.6 µM 2.15E-19 2 1.60E-18
4 SGTC_1364 1653-0028 8.16 37.6 µM 2.82E-17 1 1.64E-16
5 SGTC_773 4358-1457 8.04 44.6 µM 7.88E-17 6 4.37E-16
6 SGTC_373 0844-0104 7.33 25.9 µM 2.81E-14 ERAD & cell cycle 16 1.16E-13
7 SGTC_3123 9126162 7.33 49.5 µM 2.85E-14 1 1.18E-13
8 SGTC_1635 st007035 6.51 42.4 µM 1.23E-11 127 3.79E-11
9 SGTC_2754 granisetron 5.80 64.0 µM 1.32E-9 6 3.22E-9
10 SGTC_2949 9072542 5.68 2.2 µM 2.91E-9 TSC3-RPN4 9 6.85E-9
11 SGTC_223 busulfan 5.50 5.0 mM 8.47E-9 3 1.89E-8
12 SGTC_1137 ixabepilone 5.40 100.0 µM 1.57E-8 9 3.40E-8
13 SGTC_1741 st038134 5.26 10.2 µM 3.43E-8 9 7.17E-8
14 SGTC_1827 berberine 5.22 7.2 µM 4.41E-8 60S ribosome export 6 9.10E-8
15 SGTC_362 0310-0100 5.05 9.0 µM 1.10E-7 RPP1 & pyrimidine depletion 8 2.18E-7
16 SGTC_2313 7726885 4.73 200.0 µM 6.21E-7 RPP1 & pyrimidine depletion 20 1.13E-6
17 SGTC_1202 1988-0068 4.53 29.6 µM 1.72E-6 RNA processing & uracil transport 13 2.98E-6
18 SGTC_2756 carbadox 4.44 75.1 µM 2.62E-6 43 4.44E-6
19 SGTC_3143 9086658 4.32 49.5 µM 4.73E-6 32 7.79E-6
20 SGTC_1032 k061-1018 4.27 98.7 µM 5.94E-6 13 9.68E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 4.31E-22 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.166 7.45E-22 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.153 5.84E-19 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.151 1.66E-18 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.136 3.48E-15 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.122 1.81E-12 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.121 2.94E-12 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.120 3.77E-12 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.118 7.56E-12 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.113 6.06E-11 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.112 8.81E-11 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.110 1.93E-10 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.110 2.25E-10 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.104 2.02E-9 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.099 1.11E-8 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs