YHR167W / THP2

Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR167W / THP2

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:4.95|P-value:7.03E-7 ID:SGTC_14|Compound:0354-0009|FD-Score:3.51|P-value:3.26E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.52|P-value:5.53E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.14|P-value:2.02E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.16|P-value:8.36E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.11|P-value:3.23E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:4.71|P-value:2.28E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:6.94|P-value:6.41E-12 ID:SGTC_161|Compound:4065-0411|FD-Score:3.85|P-value:9.24E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.21|P-value:2.16E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.16|P-value:1.86E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.65|P-value:1.44E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.56|P-value:3.12E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:4.54|P-value:4.89E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.27|P-value:5.59E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.78|P-value:8.59E-9 ID:SGTC_531|Compound:3788-1495|FD-Score:3.19|P-value:9.97E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:6.37|P-value:2.49E-10 ID:SGTC_547|Compound:1120-0019|FD-Score:4.28|P-value:1.61E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.75|P-value:1.35E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:8.97|P-value:9.02E-19 ID:SGTC_565|Compound:1418-0001|FD-Score:4.76|P-value:1.75E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.76|P-value:1.78E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:3.84|P-value:9.52E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.50|P-value:6.04E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.34|P-value:5.95E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.65|P-value:1.98E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.30|P-value:1.44E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:5.10|P-value:3.38E-7 ID:SGTC_947|Compound:3447-0010|FD-Score:4.20|P-value:2.17E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.37|P-value:1.08E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.41|P-value:9.05E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.36|P-value:5.62E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.32|P-value:6.43E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.30|P-value:6.97E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.21|P-value:1.50E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:5.99|P-value:2.59E-9 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.41|P-value:4.72E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.96|P-value:6.68E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:5.83|P-value:6.58E-9 ID:SGTC_1591|Compound:genipin|FD-Score:-3.28|P-value:5.46E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.36|P-value:3.18E-13 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.93|P-value:3.75E-9 ID:SGTC_1618|Compound:st003135|FD-Score:3.21|P-value:9.43E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.20|P-value:2.18E-5 ID:SGTC_1654|Compound:st012436|FD-Score:3.51|P-value:3.27E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.19|P-value:9.99E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.28|P-value:7.38E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.05|P-value:4.09E-5 ID:SGTC_1930|Compound:st074634|FD-Score:7.86|P-value:7.86E-15 ID:SGTC_1932|Compound:st074806|FD-Score:-4.51|P-value:3.93E-6 ID:SGTC_1934|Compound:st074720|FD-Score:8.89|P-value:1.73E-18 ID:SGTC_1949|Compound:st076024|FD-Score:3.41|P-value:4.77E-4 ID:SGTC_2024|Compound:5144227|FD-Score:6.11|P-value:1.29E-9 ID:SGTC_2076|Compound:5212012|FD-Score:5.20|P-value:2.00E-7 ID:SGTC_2151|Compound:5563267|FD-Score:4.54|P-value:5.04E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.44|P-value:7.87E-6 ID:SGTC_2265|Compound:7929201|FD-Score:5.26|P-value:1.46E-7 ID:SGTC_2302|Compound:7771753|FD-Score:3.35|P-value:5.73E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.21|P-value:9.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.33|P-value:6.24E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.23|P-value:8.76E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.87|P-value:8.50E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:7.38|P-value:2.90E-13 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.56|P-value:1.99E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.25|P-value:8.14E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.71|P-value:1.56E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.66|P-value:1.90E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.48|P-value:6.41E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-6.14|P-value:6.41E-10 ID:SGTC_2789|Compound:5281112|FD-Score:3.87|P-value:8.43E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.90|P-value:7.47E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.85|P-value:9.15E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.61|P-value:3.63E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.81|P-value:1.07E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.36|P-value:5.56E-4 ID:SGTC_3269|Compound:9137823|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.42|P-value:3.32E-4 ID:SGTC_3337|Compound:9144342|FD-Score:5.44|P-value:5.83E-8 ID:SGTC_5|Compound:0352-0601|FD-Score:4.95|P-value:7.03E-7 ID:SGTC_14|Compound:0354-0009|FD-Score:3.51|P-value:3.26E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.52|P-value:5.53E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.14|P-value:2.02E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.16|P-value:8.36E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.11|P-value:3.23E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:4.71|P-value:2.28E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:6.94|P-value:6.41E-12 ID:SGTC_161|Compound:4065-0411|FD-Score:3.85|P-value:9.24E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.21|P-value:2.16E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.16|P-value:1.86E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.65|P-value:1.44E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.56|P-value:3.12E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:4.54|P-value:4.89E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.27|P-value:5.59E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.78|P-value:8.59E-9 ID:SGTC_531|Compound:3788-1495|FD-Score:3.19|P-value:9.97E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:6.37|P-value:2.49E-10 ID:SGTC_547|Compound:1120-0019|FD-Score:4.28|P-value:1.61E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.75|P-value:1.35E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:8.97|P-value:9.02E-19 ID:SGTC_565|Compound:1418-0001|FD-Score:4.76|P-value:1.75E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.76|P-value:1.78E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:3.84|P-value:9.52E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.50|P-value:6.04E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.34|P-value:5.95E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.65|P-value:1.98E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.30|P-value:1.44E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:5.10|P-value:3.38E-7 ID:SGTC_947|Compound:3447-0010|FD-Score:4.20|P-value:2.17E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.37|P-value:1.08E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.41|P-value:9.05E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.36|P-value:5.62E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.32|P-value:6.43E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.30|P-value:6.97E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.21|P-value:1.50E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:5.99|P-value:2.59E-9 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.41|P-value:4.72E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.96|P-value:6.68E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:5.83|P-value:6.58E-9 ID:SGTC_1591|Compound:genipin|FD-Score:-3.28|P-value:5.46E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.36|P-value:3.18E-13 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.93|P-value:3.75E-9 ID:SGTC_1618|Compound:st003135|FD-Score:3.21|P-value:9.43E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.20|P-value:2.18E-5 ID:SGTC_1654|Compound:st012436|FD-Score:3.51|P-value:3.27E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.19|P-value:9.99E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.28|P-value:7.38E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.05|P-value:4.09E-5 ID:SGTC_1930|Compound:st074634|FD-Score:7.86|P-value:7.86E-15 ID:SGTC_1932|Compound:st074806|FD-Score:-4.51|P-value:3.93E-6 ID:SGTC_1934|Compound:st074720|FD-Score:8.89|P-value:1.73E-18 ID:SGTC_1949|Compound:st076024|FD-Score:3.41|P-value:4.77E-4 ID:SGTC_2024|Compound:5144227|FD-Score:6.11|P-value:1.29E-9 ID:SGTC_2076|Compound:5212012|FD-Score:5.20|P-value:2.00E-7 ID:SGTC_2151|Compound:5563267|FD-Score:4.54|P-value:5.04E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.44|P-value:7.87E-6 ID:SGTC_2265|Compound:7929201|FD-Score:5.26|P-value:1.46E-7 ID:SGTC_2302|Compound:7771753|FD-Score:3.35|P-value:5.73E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.21|P-value:9.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.33|P-value:6.24E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.23|P-value:8.76E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.87|P-value:8.50E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:7.38|P-value:2.90E-13 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.56|P-value:1.99E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.25|P-value:8.14E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.71|P-value:1.56E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.66|P-value:1.90E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.48|P-value:6.41E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-6.14|P-value:6.41E-10 ID:SGTC_2789|Compound:5281112|FD-Score:3.87|P-value:8.43E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.90|P-value:7.47E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.85|P-value:9.15E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.61|P-value:3.63E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.81|P-value:1.07E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.36|P-value:5.56E-4 ID:SGTC_3269|Compound:9137823|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.42|P-value:3.32E-4 ID:SGTC_3337|Compound:9144342|FD-Score:5.44|P-value:5.83E-8

Top fitness defect scores for YHR167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 8.97 112.0 µM 9.02E-19 ERG2 13 1.49E-19
2 SGTC_1934 st074720 8.89 32.6 µM 1.73E-18 6 2.95E-19
3 SGTC_1930 st074634 7.86 34.3 µM 7.86E-15 RNA pol III & RNase P/MRP 5 1.89E-15
4 SGTC_2604 4'-hydroxychalcone 7.38 11.3 µM 2.90E-13 3 8.08E-14
5 SGTC_1597 7-benzyloxygramine 7.36 47.5 µM 3.18E-13 calcium & mitochondrial duress 31 8.91E-14
6 SGTC_146 3448-8650 6.94 53.1 µM 6.41E-12 NEO1-PIK1 37 2.03E-12
7 SGTC_543 3844-1095 6.37 191.0 µM 2.49E-10 ERG2 16 9.21E-11
8 SGTC_2024 5144227 6.11 134.0 µM 1.29E-9 10 5.12E-10
9 SGTC_1578 josamycin 5.99 24.2 µM 2.59E-9 2 1.06E-9
10 SGTC_1599 8-chlro-1-tetrahydronorharmanone 5.93 90.6 µM 3.75E-9 8 1.56E-9
11 SGTC_1582 3',3',6'-trihydroxyflavone 5.83 74.0 µM 6.58E-9 4 2.79E-9
12 SGTC_528 3492-0019 5.78 172.0 µM 8.59E-9 calcium & mitochondrial duress 129 3.69E-9
13 SGTC_3337 9144342 5.44 33.5 µM 5.83E-8 14 2.72E-8
14 SGTC_2265 7929201 5.26 200.0 µM 1.46E-7 6 7.08E-8
15 SGTC_2076 5212012 5.20 200.0 µM 2.00E-7 1 9.84E-8
16 SGTC_72 0744-0168 5.11 198.4 µM 3.23E-7 RPP1 & pyrimidine depletion 11 1.62E-7
17 SGTC_945 3381-0768 5.10 11.3 µM 3.38E-7 endomembrane recycling 12 1.70E-7
18 SGTC_1581 himbacine 4.96 57.9 µM 6.68E-7 Golgi 32 3.45E-7
19 SGTC_5 0352-0601 4.95 109.9 µM 7.03E-7 ERG2 8 3.64E-7
20 SGTC_565 1418-0001 4.76 44.5 µM 1.75E-6 5 9.46E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.351 6.45E-98 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.213 1.35E-35 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.209 1.64E-34 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.207 7.58E-34 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.199 3.75E-31 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.184 6.77E-27 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.182 2.48E-26 YGR064W_d YGR064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
0.168 9.86E-23 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.168 1.38E-22 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.162 2.88E-21 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.160 1.55E-20 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.155 1.49E-19 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.149 3.42E-18 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.146 1.62E-17 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.145 3.88E-17 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion