YHR168W / MTG2

Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR168W / MTG2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.20|P-value:4.50E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.15|P-value:5.31E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.25|P-value:3.72E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.99|P-value:5.59E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:11.60|P-value:6.91E-34 ID:SGTC_251|Compound:melphalan|FD-Score:3.58|P-value:1.03E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.32|P-value:2.80E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.95|P-value:1.35E-7 ID:SGTC_298|Compound:1391-0729|FD-Score:3.31|P-value:2.91E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.52|P-value:2.63E-23 ID:SGTC_314|Compound:1671-0008|FD-Score:3.89|P-value:2.70E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:4.10|P-value:1.03E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.00|P-value:9.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.30|P-value:3.06E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.94|P-value:2.15E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.75|P-value:5.08E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.84|P-value:3.42E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.72|P-value:5.56E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.08|P-value:1.19E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.41|P-value:2.46E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.60|P-value:9.21E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.06|P-value:7.54E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.09|P-value:6.61E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.56|P-value:1.10E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.90|P-value:2.54E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:2.98|P-value:9.85E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.07|P-value:7.22E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.65|P-value:6.77E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.13|P-value:9.09E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.01|P-value:1.58E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.17|P-value:4.97E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.19|P-value:4.77E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.09|P-value:6.80E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.06|P-value:1.24E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.47|P-value:1.60E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:6.61|P-value:3.39E-12 ID:SGTC_1615|Compound:st002656|FD-Score:3.07|P-value:7.11E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.97|P-value:1.92E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.15|P-value:8.30E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.35|P-value:2.49E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.06|P-value:7.59E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.05|P-value:7.65E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.68|P-value:6.93E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.85|P-value:3.18E-5 ID:SGTC_1742|Compound:st038235|FD-Score:12.90|P-value:2.83E-41 ID:SGTC_1769|Compound:st044406|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.98|P-value:6.16E-17 ID:SGTC_1891|Compound:st059073|FD-Score:3.49|P-value:1.45E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.80|P-value:3.99E-5 ID:SGTC_1935|Compound:st074532|FD-Score:4.60|P-value:9.05E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-4.82|P-value:2.95E-7 ID:SGTC_2023|Compound:5144124|FD-Score:3.04|P-value:7.91E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.35|P-value:3.24E-6 ID:SGTC_2069|Compound:5228469|FD-Score:-3.15|P-value:5.53E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.91|P-value:1.74E-7 ID:SGTC_2243|Compound:6634756|FD-Score:3.22|P-value:4.16E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.55|P-value:1.15E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.94|P-value:2.20E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.47|P-value:1.60E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.21|P-value:6.29E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.03|P-value:8.33E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.25|P-value:3.80E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-5.14|P-value:5.01E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.70|P-value:6.23E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.31|P-value:2.95E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.05|P-value:7.87E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.75|P-value:1.18E-9 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.01|P-value:1.55E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.90|P-value:2.62E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.81|P-value:3.08E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.32|P-value:2.88E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.04|P-value:7.98E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.14|P-value:5.66E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.38|P-value:2.33E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.33|P-value:2.79E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.05|P-value:7.70E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.64|P-value:7.68E-7 ID:SGTC_3018|Compound:9082602|FD-Score:3.22|P-value:4.12E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.20|P-value:4.50E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.15|P-value:5.31E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.25|P-value:3.72E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.99|P-value:5.59E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:11.60|P-value:6.91E-34 ID:SGTC_251|Compound:melphalan|FD-Score:3.58|P-value:1.03E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.32|P-value:2.80E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.95|P-value:1.35E-7 ID:SGTC_298|Compound:1391-0729|FD-Score:3.31|P-value:2.91E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.52|P-value:2.63E-23 ID:SGTC_314|Compound:1671-0008|FD-Score:3.89|P-value:2.70E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:4.10|P-value:1.03E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.00|P-value:9.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.30|P-value:3.06E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.94|P-value:2.15E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.75|P-value:5.08E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.84|P-value:3.42E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.72|P-value:5.56E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.08|P-value:1.19E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.41|P-value:2.46E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.60|P-value:9.21E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.06|P-value:7.54E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.09|P-value:6.61E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.56|P-value:1.10E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.90|P-value:2.54E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:2.98|P-value:9.85E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.07|P-value:7.22E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.65|P-value:6.77E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.13|P-value:9.09E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.01|P-value:1.58E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.17|P-value:4.97E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.19|P-value:4.77E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.09|P-value:6.80E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.06|P-value:1.24E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.47|P-value:1.60E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:6.61|P-value:3.39E-12 ID:SGTC_1615|Compound:st002656|FD-Score:3.07|P-value:7.11E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.97|P-value:1.92E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.15|P-value:8.30E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.35|P-value:2.49E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.06|P-value:7.59E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.05|P-value:7.65E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.68|P-value:6.93E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.85|P-value:3.18E-5 ID:SGTC_1742|Compound:st038235|FD-Score:12.90|P-value:2.83E-41 ID:SGTC_1769|Compound:st044406|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.98|P-value:6.16E-17 ID:SGTC_1891|Compound:st059073|FD-Score:3.49|P-value:1.45E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.80|P-value:3.99E-5 ID:SGTC_1935|Compound:st074532|FD-Score:4.60|P-value:9.05E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-4.82|P-value:2.95E-7 ID:SGTC_2023|Compound:5144124|FD-Score:3.04|P-value:7.91E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.35|P-value:3.24E-6 ID:SGTC_2069|Compound:5228469|FD-Score:-3.15|P-value:5.53E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.91|P-value:1.74E-7 ID:SGTC_2243|Compound:6634756|FD-Score:3.22|P-value:4.16E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.55|P-value:1.15E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.94|P-value:2.20E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.47|P-value:1.60E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.21|P-value:6.29E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.03|P-value:8.33E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.25|P-value:3.80E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-5.14|P-value:5.01E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.70|P-value:6.23E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.31|P-value:2.95E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-3.05|P-value:7.87E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.75|P-value:1.18E-9 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.01|P-value:1.55E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.90|P-value:2.62E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.81|P-value:3.08E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.32|P-value:2.88E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.04|P-value:7.98E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.14|P-value:5.66E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.38|P-value:2.33E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.33|P-value:2.79E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.05|P-value:7.70E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.64|P-value:7.68E-7 ID:SGTC_3018|Compound:9082602|FD-Score:3.22|P-value:4.12E-4

Top fitness defect scores for YHR168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1742 st038235 12.90 28.9 µM 2.83E-41 mitochondrial stress 2 1.77E-38
2 SGTC_236 1509-0011 11.60 5.3 µM 6.91E-34 157 1.30E-31
3 SGTC_310 1273-0058 9.52 1.1 µM 2.63E-23 mitochondrial stress 50 8.86E-22
4 SGTC_173 1273-0061 7.99 2.7 µM 5.59E-17 mitochondrial stress 66 6.76E-16
5 SGTC_1574 spiramycin 6.61 23.7 µM 3.39E-12 4 1.89E-11
6 SGTC_2751 anetholtrithion 5.75 17.2 µM 1.18E-9 7 4.38E-9
7 SGTC_275 trichlorophene 4.95 5.7 µM 1.35E-7 mitochondrial stress 170 3.62E-7
8 SGTC_2232 chlorophetanol 4.91 41.5 µM 1.74E-7 TRP & mitochondrial translation 81 4.56E-7
9 SGTC_1020 4335-0961 4.65 93.3 µM 6.77E-7 4 1.62E-6
10 SGTC_1935 st074532 4.60 41.6 µM 9.05E-7 18 2.12E-6
11 SGTC_2041 5107442 4.35 45.3 µM 3.24E-6 RSC complex & mRNA processing 19 6.96E-6
12 SGTC_2310 7668677 4.21 200.0 µM 6.29E-6 21 1.29E-5
13 SGTC_1627 st003713 4.15 25.6 µM 8.30E-6 calcium & mitochondrial duress 66 1.67E-5
14 SGTC_1125 tnp00248 4.13 1.3 µM 9.09E-6 20 1.82E-5
15 SGTC_365 0121-0052 4.10 13.6 µM 1.03E-5 mitochondrial response to ROS 50 2.04E-5
16 SGTC_1465 k213-0056 4.06 144.0 µM 1.24E-5 DNA intercalators 21 2.44E-5
17 SGTC_2757 clomiphene 4.01 4.2 µM 1.55E-5 fatty acid desaturase (OLE1) 38 3.00E-5
18 SGTC_1188 1403-0014 4.01 4.6 µM 1.58E-5 mitochondrial stress 49 3.05E-5
19 SGTC_1623 st003709 3.97 20.3 µM 1.92E-5 calcium & mitochondrial duress 70 3.66E-5
20 SGTC_462 ag-879 3.94 158.0 µM 2.15E-5 30 4.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.493 1.10E-204 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.488 4.64E-199 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.479 4.63E-192 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.460 1.45E-175 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.457 5.06E-173 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.454 1.98E-170 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.452 4.36E-168 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.452 3.44E-168 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.450 3.39E-167 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.437 2.83E-156 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.432 2.50E-152 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.431 9.55E-152 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.429 2.78E-150 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.425 3.98E-147 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.421 1.27E-144 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function