YHR172W / SPC97

Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR172W / SPC97

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.15|P-value:4.42E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:7.69|P-value:1.90E-13 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.73|P-value:3.93E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.57|P-value:3.75E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:4.99|P-value:1.22E-6 ID:SGTC_92|Compound:0063-0024|FD-Score:3.83|P-value:1.52E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:4.45|P-value:1.33E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.88|P-value:1.25E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.14|P-value:4.71E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:5.46|P-value:1.24E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:12.20|P-value:4.36E-31 ID:SGTC_166|Compound:k072-0058|FD-Score:7.28|P-value:3.14E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.60|P-value:6.73E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:5.00|P-value:1.17E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.29|P-value:9.58E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.46|P-value:1.25E-5 ID:SGTC_264|Compound:promethazine|FD-Score:9.78|P-value:1.27E-20 ID:SGTC_370|Compound:0180-0345|FD-Score:7.65|P-value:2.58E-13 ID:SGTC_378|Compound:3970-0959|FD-Score:3.83|P-value:1.51E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.98|P-value:8.50E-5 ID:SGTC_470|Compound:aa-861|FD-Score:6.07|P-value:4.97E-9 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:7.26|P-value:3.61E-12 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.80|P-value:1.66E-4 ID:SGTC_512|Compound:prima-1|FD-Score:6.75|P-value:9.00E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:5.40|P-value:1.74E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:3.45|P-value:5.68E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.61|P-value:6.60E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:5.55|P-value:8.18E-8 ID:SGTC_916|Compound:4466-0038|FD-Score:4.18|P-value:3.90E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.71|P-value:2.32E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.95|P-value:1.49E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.10|P-value:5.34E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.35|P-value:7.81E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.37|P-value:7.27E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.30|P-value:9.29E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.19|P-value:3.81E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.11|P-value:5.32E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.64|P-value:2.91E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.32|P-value:8.55E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.52|P-value:9.70E-6 ID:SGTC_1756|Compound:st041558|FD-Score:3.29|P-value:9.40E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.01|P-value:7.68E-5 ID:SGTC_1807|Compound:st050092|FD-Score:5.08|P-value:7.98E-7 ID:SGTC_1810|Compound:st050138|FD-Score:-3.55|P-value:3.89E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.01|P-value:1.12E-6 ID:SGTC_1932|Compound:st074806|FD-Score:3.58|P-value:3.68E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.92|P-value:1.06E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-4.49|P-value:1.11E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.76|P-value:1.90E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-5.52|P-value:9.09E-8 ID:SGTC_2282|Compound:7944268|FD-Score:7.70|P-value:1.77E-13 ID:SGTC_2290|Compound:7904846|FD-Score:6.33|P-value:1.15E-9 ID:SGTC_2379|Compound:9035213|FD-Score:4.12|P-value:5.09E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.18|P-value:3.92E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.45|P-value:1.32E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:7.28|P-value:3.06E-12 ID:SGTC_2625|Compound:euphol|FD-Score:4.06|P-value:6.28E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.86|P-value:4.74E-11 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.57|P-value:3.75E-4 ID:SGTC_2906|Compound:7926292|FD-Score:5.66|P-value:4.51E-8 ID:SGTC_3012|Compound:9080433|FD-Score:-4.36|P-value:1.86E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.52|P-value:4.47E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.06|P-value:6.26E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.30|P-value:9.34E-4 ID:SGTC_3199|Compound:9111318|FD-Score:8.23|P-value:3.79E-15 ID:SGTC_3200|Compound:9114385|FD-Score:4.70|P-value:4.56E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:4.15|P-value:4.42E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:7.69|P-value:1.90E-13 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.73|P-value:3.93E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.57|P-value:3.75E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:4.99|P-value:1.22E-6 ID:SGTC_92|Compound:0063-0024|FD-Score:3.83|P-value:1.52E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:4.45|P-value:1.33E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.88|P-value:1.25E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.14|P-value:4.71E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:5.46|P-value:1.24E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:12.20|P-value:4.36E-31 ID:SGTC_166|Compound:k072-0058|FD-Score:7.28|P-value:3.14E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.60|P-value:6.73E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:5.00|P-value:1.17E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.29|P-value:9.58E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.46|P-value:1.25E-5 ID:SGTC_264|Compound:promethazine|FD-Score:9.78|P-value:1.27E-20 ID:SGTC_370|Compound:0180-0345|FD-Score:7.65|P-value:2.58E-13 ID:SGTC_378|Compound:3970-0959|FD-Score:3.83|P-value:1.51E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.98|P-value:8.50E-5 ID:SGTC_470|Compound:aa-861|FD-Score:6.07|P-value:4.97E-9 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:7.26|P-value:3.61E-12 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.80|P-value:1.66E-4 ID:SGTC_512|Compound:prima-1|FD-Score:6.75|P-value:9.00E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:5.40|P-value:1.74E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:3.45|P-value:5.68E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.61|P-value:6.60E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:5.55|P-value:8.18E-8 ID:SGTC_916|Compound:4466-0038|FD-Score:4.18|P-value:3.90E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.71|P-value:2.32E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.95|P-value:1.49E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.10|P-value:5.34E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.35|P-value:7.81E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.37|P-value:7.27E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.30|P-value:9.29E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.19|P-value:3.81E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.11|P-value:5.32E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.64|P-value:2.91E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.32|P-value:8.55E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.52|P-value:9.70E-6 ID:SGTC_1756|Compound:st041558|FD-Score:3.29|P-value:9.40E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.01|P-value:7.68E-5 ID:SGTC_1807|Compound:st050092|FD-Score:5.08|P-value:7.98E-7 ID:SGTC_1810|Compound:st050138|FD-Score:-3.55|P-value:3.89E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.01|P-value:1.12E-6 ID:SGTC_1932|Compound:st074806|FD-Score:3.58|P-value:3.68E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.92|P-value:1.06E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-4.49|P-value:1.11E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.76|P-value:1.90E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-5.52|P-value:9.09E-8 ID:SGTC_2282|Compound:7944268|FD-Score:7.70|P-value:1.77E-13 ID:SGTC_2290|Compound:7904846|FD-Score:6.33|P-value:1.15E-9 ID:SGTC_2379|Compound:9035213|FD-Score:4.12|P-value:5.09E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.18|P-value:3.92E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.45|P-value:1.32E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:7.28|P-value:3.06E-12 ID:SGTC_2625|Compound:euphol|FD-Score:4.06|P-value:6.28E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.86|P-value:4.74E-11 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.57|P-value:3.75E-4 ID:SGTC_2906|Compound:7926292|FD-Score:5.66|P-value:4.51E-8 ID:SGTC_3012|Compound:9080433|FD-Score:-4.36|P-value:1.86E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.52|P-value:4.47E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.06|P-value:6.26E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.30|P-value:9.34E-4 ID:SGTC_3199|Compound:9111318|FD-Score:8.23|P-value:3.79E-15 ID:SGTC_3200|Compound:9114385|FD-Score:4.70|P-value:4.56E-6

Top fitness defect scores for YHR172W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 12.20 7.5 µM 4.36E-31 8 1.31E-34 0.22
2 SGTC_264 promethazine 9.78 12.5 mM 1.27E-20 DNA intercalators 5 6.86E-23 0.47
3 SGTC_3199 9111318 8.23 49.5 µM 3.79E-15 2 9.17E-17 2.29
4 SGTC_2282 7944268 7.70 200.0 µM 1.77E-13 RPP1 & pyrimidine depletion 2 6.77E-15 0.05
5 SGTC_43 0570-0105 7.69 72.5 µM 1.90E-13 ERG2 2 7.33E-15 0.97
6 SGTC_370 0180-0345 7.65 38.7 µM 2.58E-13 DNA intercalators 1 1.03E-14 2.07
7 SGTC_2619 obliquin 7.28 87.9 µM 3.06E-12 cell wall 10 1.64E-13 0.28
8 SGTC_166 k072-0058 7.28 166.4 µM 3.14E-12 DNA intercalators 1 1.69E-13 1.98
9 SGTC_471 1-acyl-paf 7.26 4.0 µM 3.61E-12 DNA intercalators 5 1.97E-13 0.69
10 SGTC_2651 1327-0036 6.86 5.0 µM 4.74E-11 26 3.51E-12 0.01
11 SGTC_512 prima-1 6.75 270.0 µM 9.00E-11 DNA intercalators 1 7.19E-12 0.78
12 SGTC_2290 7904846 6.33 200.0 µM 1.15E-9 5 1.25E-10 1.21
13 SGTC_470 aa-861 6.07 153.0 µM 4.97E-9 sphingolipid biosynthesis & PDR1 3 6.38E-10 0.04
14 SGTC_2906 7926292 5.66 26.4 µM 4.51E-8 2 7.50E-9 1.41
15 SGTC_867 0518-0118 5.55 155.0 µM 8.18E-8 DNA intercalators 8 1.46E-8 1.00
16 SGTC_145 3737-0113 5.46 38.4 µM 1.24E-7 DNA intercalators 24 2.32E-8 0.09
17 SGTC_514 4466-0038 5.40 2.6 nM 1.74E-7 cell wall 23 3.38E-8 0.17
18 SGTC_1807 st050092 5.08 58.9 µM 7.98E-7 60S ribosome export 1 1.86E-7 0.59
19 SGTC_1926 methyl fluorone black 5.01 53.6 µM 1.12E-6 DNA intercalators 16 2.72E-7 0.03
20 SGTC_171 k064-0041 5.00 9.7 µM 1.17E-6 heme requiring 10 2.86E-7 0.42

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.365 2.06E-106 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.343 4.80E-93 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.325 4.03E-83 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.312 1.43E-76 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.304 7.27E-73 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.297 2.34E-69 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.270 4.37E-57 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.267 1.08E-55 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.261 4.05E-53 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.228 1.11E-40 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.219 1.44E-37 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.209 1.85E-34 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.208 4.42E-34 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.198 4.36E-31 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.197 8.61E-31 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs