YHR175W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR175W-A / YHR175W-A

Click on Significant Values for Screen Details ID:SGTC_150|Compound:3970-0969|FD-Score:-3.44|P-value:8.05E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.27|P-value:1.65E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.62|P-value:3.61E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.30|P-value:1.47E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.16|P-value:7.56E-9 ID:SGTC_252|Compound:miconazole|FD-Score:2.98|P-value:5.43E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.60|P-value:2.23E-7 ID:SGTC_443|Compound:clozapine|FD-Score:3.95|P-value:7.22E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.06|P-value:4.15E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:-2.86|P-value:8.35E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.91|P-value:8.87E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:3.14|P-value:2.79E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.26|P-value:1.76E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.12|P-value:3.07E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.03|P-value:4.45E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.75|P-value:1.40E-10 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.32|P-value:1.08E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.63|P-value:3.34E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.93|P-value:6.45E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.85|P-value:8.79E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.89|P-value:9.51E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.17|P-value:2.51E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.34|P-value:1.25E-4 ID:SGTC_1797|Compound:st048695|FD-Score:2.88|P-value:7.85E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.47|P-value:7.10E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.12|P-value:3.11E-6 ID:SGTC_1977|Compound:st070720|FD-Score:-2.95|P-value:5.88E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.14|P-value:2.86E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.81|P-value:1.46E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.60|P-value:2.19E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.46|P-value:7.32E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.47|P-value:7.00E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.85|P-value:1.17E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.82|P-value:1.38E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-2.82|P-value:9.70E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.24|P-value:1.64E-6 ID:SGTC_2995|Compound:9067767|FD-Score:2.88|P-value:7.72E-4 ID:SGTC_3090|Compound:9117696|FD-Score:2.94|P-value:6.25E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.53|P-value:5.31E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.39|P-value:9.96E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.58|P-value:4.28E-5 ID:SGTC_3345|Compound:9148410|FD-Score:3.55|P-value:4.94E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.44|P-value:8.05E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.27|P-value:1.65E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.62|P-value:3.61E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.30|P-value:1.47E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.16|P-value:7.56E-9 ID:SGTC_252|Compound:miconazole|FD-Score:2.98|P-value:5.43E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.60|P-value:2.23E-7 ID:SGTC_443|Compound:clozapine|FD-Score:3.95|P-value:7.22E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.06|P-value:4.15E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:-2.86|P-value:8.35E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.91|P-value:8.87E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:3.14|P-value:2.79E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.26|P-value:1.76E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.12|P-value:3.07E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.03|P-value:4.45E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.75|P-value:1.40E-10 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.32|P-value:1.08E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.63|P-value:3.34E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.93|P-value:6.45E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.85|P-value:8.79E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.89|P-value:9.51E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.17|P-value:2.51E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.34|P-value:1.25E-4 ID:SGTC_1797|Compound:st048695|FD-Score:2.88|P-value:7.85E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.47|P-value:7.10E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.12|P-value:3.11E-6 ID:SGTC_1977|Compound:st070720|FD-Score:-2.95|P-value:5.88E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.14|P-value:2.86E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.81|P-value:1.46E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.60|P-value:2.19E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.46|P-value:7.32E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.47|P-value:7.00E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.85|P-value:1.17E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.82|P-value:1.38E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-2.82|P-value:9.70E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.24|P-value:1.64E-6 ID:SGTC_2995|Compound:9067767|FD-Score:2.88|P-value:7.72E-4 ID:SGTC_3090|Compound:9117696|FD-Score:2.94|P-value:6.25E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.53|P-value:5.31E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.39|P-value:9.96E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.58|P-value:4.28E-5 ID:SGTC_3345|Compound:9148410|FD-Score:3.55|P-value:4.94E-5

Top fitness defect scores for YHR175W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 5.75 42.5 µM 1.40E-10 9 4.57E-9
2 SGTC_236 1509-0011 5.16 5.3 µM 7.56E-9 320 1.27E-7
3 SGTC_2610 ononetin 4.60 44.2 µM 2.19E-7 23 2.10E-6
4 SGTC_358 0075-0058 4.60 9.4 µM 2.23E-7 40 2.14E-6
5 SGTC_1216 1165-0504 4.32 9.7 µM 1.08E-6 9 7.95E-6
6 SGTC_1872 amphotericin b 4.12 148.0 nM 3.11E-6 RNA pol III & RNase P/MRP 24 1.93E-5
7 SGTC_443 clozapine 3.95 122.0 µM 7.22E-6 NEO1-PIK1 10 3.90E-5
8 SGTC_976 1348-1067 3.91 47.6 µM 8.87E-6 60S ribosome export 34 4.64E-5
9 SGTC_1626 st003712 3.89 1.8 µM 9.51E-6 25 4.92E-5
10 SGTC_2789 5281112 3.85 71.4 µM 1.17E-5 41 5.85E-5
11 SGTC_2929 9013348 3.82 24.6 µM 1.38E-5 24 6.73E-5
12 SGTC_1260 0700-1617 3.63 7.8 µM 3.34E-5 calcium & mitochondrial duress 38 1.41E-4
13 SGTC_203 k066-0004 3.62 30.9 µM 3.61E-5 RSC & ERG11 27 1.50E-4
14 SGTC_3300 9124615 3.58 50.5 µM 4.28E-5 30 1.73E-4
15 SGTC_3345 9148410 3.55 3.6 µM 4.94E-5 13 1.95E-4
16 SGTC_1826 st055655 3.47 41.6 µM 7.10E-5 ERG2 58 2.65E-4
17 SGTC_2627 acetyl isogambogic acid 3.46 100.0 µM 7.32E-5 TSC3-RPN4 62 2.72E-4
18 SGTC_3144 9087057 3.39 49.5 µM 9.96E-5 30 3.52E-4
19 SGTC_213 1246-0773 3.30 967.0 nM 1.47E-4 48 4.87E-4
20 SGTC_992 3909-8734 3.26 162.0 µM 1.76E-4 41 5.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 5.74E-48 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.237 5.73E-44 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
0.234 4.47E-43 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.234 6.84E-43 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.225 1.01E-39 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.217 4.02E-37 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.212 1.88E-35 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.212 2.41E-35 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.210 1.38E-34 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.209 1.77E-34 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.206 2.15E-33 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.205 3.45E-33 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.202 2.34E-32 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.202 2.52E-32 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.200 1.42E-31 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit