YHR176W / FMO1

Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR176W / FMO1

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:4.20|P-value:1.05E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:3.27|P-value:4.74E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.79|P-value:6.15E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:4.08|P-value:1.84E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:4.45|P-value:3.24E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.78|P-value:6.53E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.13|P-value:7.85E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.12|P-value:7.94E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.64|P-value:5.38E-9 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.07|P-value:8.72E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.57|P-value:1.53E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.13|P-value:7.03E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.02|P-value:2.36E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.58|P-value:1.31E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.57|P-value:1.38E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.18|P-value:6.01E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.23|P-value:5.33E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.19|P-value:1.08E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.70|P-value:8.95E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.56|P-value:1.44E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.63|P-value:1.21E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-5.18|P-value:6.86E-8 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.66|P-value:1.05E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.98|P-value:2.75E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.47|P-value:2.20E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.70|P-value:9.14E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.45|P-value:2.42E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.19|P-value:1.09E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.34|P-value:3.67E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.09|P-value:8.85E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.23|P-value:5.34E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.11|P-value:8.42E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.88|P-value:3.84E-7 ID:SGTC_1913|Compound:st060213|FD-Score:-3.72|P-value:7.41E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.18|P-value:6.55E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.29|P-value:3.96E-4 ID:SGTC_2108|Compound:5365811|FD-Score:4.36|P-value:5.10E-6 ID:SGTC_2157|Compound:5649910|FD-Score:-3.04|P-value:9.66E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.80|P-value:5.33E-5 ID:SGTC_2397|Compound:5161689|FD-Score:4.20|P-value:1.08E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.19|P-value:6.20E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.16|P-value:1.28E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.40|P-value:2.62E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.46|P-value:1.35E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.24|P-value:8.82E-6 ID:SGTC_2691|Compound:st077356|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.61|P-value:1.49E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.94|P-value:2.75E-7 ID:SGTC_2782|Compound:7736369|FD-Score:4.45|P-value:3.34E-6 ID:SGTC_2816|Compound:7982706|FD-Score:5.81|P-value:1.99E-9 ID:SGTC_2818|Compound:7996756|FD-Score:5.90|P-value:1.15E-9 ID:SGTC_2820|Compound:7989630|FD-Score:-3.74|P-value:7.03E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.87|P-value:3.96E-7 ID:SGTC_2824|Compound:7998404|FD-Score:4.53|P-value:2.28E-6 ID:SGTC_2828|Compound:7998861|FD-Score:-3.22|P-value:5.21E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.87|P-value:4.49E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.10|P-value:8.70E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.42|P-value:3.81E-6 ID:SGTC_3045|Compound:9092950|FD-Score:-3.53|P-value:1.59E-4 ID:SGTC_3056|Compound:9094900|FD-Score:6.76|P-value:3.64E-12 ID:SGTC_3057|Compound:9095946|FD-Score:3.40|P-value:2.86E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.89|P-value:4.07E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.29|P-value:7.15E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.46|P-value:2.14E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.20|P-value:6.11E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.13|P-value:7.72E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.17|P-value:6.14E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:4.20|P-value:1.05E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:3.27|P-value:4.74E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.79|P-value:6.15E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:4.08|P-value:1.84E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:4.45|P-value:3.24E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.78|P-value:6.53E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.13|P-value:7.85E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.12|P-value:7.94E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.64|P-value:5.38E-9 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.07|P-value:8.72E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.57|P-value:1.53E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.13|P-value:7.03E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.02|P-value:2.36E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.58|P-value:1.31E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.57|P-value:1.38E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.18|P-value:6.01E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.23|P-value:5.33E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.19|P-value:1.08E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.70|P-value:8.95E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.56|P-value:1.44E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.63|P-value:1.21E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-5.18|P-value:6.86E-8 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.66|P-value:1.05E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.98|P-value:2.75E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.47|P-value:2.20E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.70|P-value:9.14E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.45|P-value:2.42E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.19|P-value:1.09E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.34|P-value:3.67E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.09|P-value:8.85E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.23|P-value:5.34E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.11|P-value:8.42E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.88|P-value:3.84E-7 ID:SGTC_1913|Compound:st060213|FD-Score:-3.72|P-value:7.41E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.18|P-value:6.55E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.29|P-value:3.96E-4 ID:SGTC_2108|Compound:5365811|FD-Score:4.36|P-value:5.10E-6 ID:SGTC_2157|Compound:5649910|FD-Score:-3.04|P-value:9.66E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.80|P-value:5.33E-5 ID:SGTC_2397|Compound:5161689|FD-Score:4.20|P-value:1.08E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.19|P-value:6.20E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.16|P-value:1.28E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.40|P-value:2.62E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.46|P-value:1.35E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.24|P-value:8.82E-6 ID:SGTC_2691|Compound:st077356|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.61|P-value:1.49E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.94|P-value:2.75E-7 ID:SGTC_2782|Compound:7736369|FD-Score:4.45|P-value:3.34E-6 ID:SGTC_2816|Compound:7982706|FD-Score:5.81|P-value:1.99E-9 ID:SGTC_2818|Compound:7996756|FD-Score:5.90|P-value:1.15E-9 ID:SGTC_2820|Compound:7989630|FD-Score:-3.74|P-value:7.03E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.87|P-value:3.96E-7 ID:SGTC_2824|Compound:7998404|FD-Score:4.53|P-value:2.28E-6 ID:SGTC_2828|Compound:7998861|FD-Score:-3.22|P-value:5.21E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.87|P-value:4.49E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.10|P-value:8.70E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.42|P-value:3.81E-6 ID:SGTC_3045|Compound:9092950|FD-Score:-3.53|P-value:1.59E-4 ID:SGTC_3056|Compound:9094900|FD-Score:6.76|P-value:3.64E-12 ID:SGTC_3057|Compound:9095946|FD-Score:3.40|P-value:2.86E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.89|P-value:4.07E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.29|P-value:7.15E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.46|P-value:2.14E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.20|P-value:6.11E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.13|P-value:7.72E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.17|P-value:6.14E-4

Top fitness defect scores for YHR176W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3056 9094900 6.76 49.5 µM 3.64E-12 1 6.90E-12
2 SGTC_2818 7996756 5.90 13.0 µM 1.15E-9 3 1.86E-9
3 SGTC_2816 7982706 5.81 58.4 µM 1.99E-9 azole & statin 18 3.16E-9
4 SGTC_515 4092-1064 5.64 102.0 µM 5.38E-9 plasma membrane duress 27 8.34E-9
5 SGTC_2772 vinpocetine 4.94 57.1 µM 2.75E-7 10 3.83E-7
6 SGTC_1861 st057647 4.88 17.4 µM 3.84E-7 6 5.29E-7
7 SGTC_2823 7987624 4.87 58.4 µM 3.96E-7 10 5.46E-7
8 SGTC_124 0136-0217 4.79 7.1 µM 6.15E-7 mitochondrial stress 36 8.37E-7
9 SGTC_2771 fluoxetine 4.61 41.0 µM 1.49E-6 11 1.98E-6
10 SGTC_2824 7998404 4.53 52.0 µM 2.28E-6 22 2.99E-6
11 SGTC_136 0097-0015 4.45 404.5 µM 3.24E-6 60S ribosome export 10 4.22E-6
12 SGTC_2782 7736369 4.45 71.4 µM 3.34E-6 25 4.35E-6
13 SGTC_2949 9072542 4.42 2.2 µM 3.81E-6 TSC3-RPN4 27 4.94E-6
14 SGTC_2108 5365811 4.36 200.0 µM 5.10E-6 8 6.57E-6
15 SGTC_3254 9136651 4.29 49.5 µM 7.15E-6 DNA damage response 16 9.13E-6
16 SGTC_2587 piperic acid 4.24 92.2 µM 8.82E-6 17 1.12E-5
17 SGTC_105 0111-0055 4.20 734.8 µM 1.05E-5 3 1.33E-5
18 SGTC_2397 5161689 4.20 200.0 µM 1.08E-5 25 1.36E-5
19 SGTC_1147 3809-1045 4.19 12.3 µM 1.08E-5 18 1.37E-5
20 SGTC_1649 st011737 4.19 51.3 µM 1.09E-5 26 1.38E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.93E-10 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.095 3.13E-8 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.091 1.38E-7 YPL016W SWI1 het Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
0.091 1.40E-7 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.089 2.80E-7 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.088 3.23E-7 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.084 1.01E-6 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.082 1.99E-6 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.082 2.23E-6 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.080 3.41E-6 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.077 7.62E-6 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.075 1.48E-5 YPR056W TFB4 het Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
0.074 1.85E-5 YBR210W ERV15 hom Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication
0.073 2.28E-5 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.072 3.11E-5 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication