YHR177W_p

Putative protein of unknown function; overexpression causes a cell cycle delay or arrest

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR177W / YHR177W

Click on Significant Values for Screen Details ID:SGTC_150|Compound:3970-0969|FD-Score:3.66|P-value:1.31E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.48|P-value:2.63E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.75|P-value:9.36E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.59|P-value:1.76E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.65|P-value:1.80E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.20|P-value:7.08E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.96|P-value:3.96E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.71|P-value:1.09E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.30|P-value:5.02E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.73|P-value:9.93E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:5.34|P-value:5.24E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:3.46|P-value:2.84E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.27|P-value:5.57E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.29|P-value:5.16E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.51|P-value:2.26E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.64|P-value:1.42E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.78|P-value:9.27E-7 ID:SGTC_1847|Compound:st056231|FD-Score:3.49|P-value:2.51E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.13|P-value:8.73E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.11|P-value:9.91E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.17|P-value:7.83E-4 ID:SGTC_1969|Compound:st069479|FD-Score:-3.38|P-value:3.57E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.96|P-value:3.98E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.32|P-value:4.78E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.66|P-value:1.33E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.21|P-value:6.83E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.55|P-value:2.06E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.68|P-value:1.25E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.37|P-value:3.89E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.10|P-value:2.11E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.12|P-value:9.16E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.24|P-value:9.01E-8 ID:SGTC_3213|Compound:9129884|FD-Score:-3.37|P-value:3.80E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.34|P-value:7.13E-6 ID:SGTC_3271|Compound:9137798|FD-Score:-4.12|P-value:1.91E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.91|P-value:4.84E-7 ID:SGTC_3274|Compound:9138298|FD-Score:7.73|P-value:6.43E-15 ID:SGTC_150|Compound:3970-0969|FD-Score:3.66|P-value:1.31E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.48|P-value:2.63E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.75|P-value:9.36E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.59|P-value:1.76E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.65|P-value:1.80E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.20|P-value:7.08E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.96|P-value:3.96E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.71|P-value:1.09E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.30|P-value:5.02E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.73|P-value:9.93E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:5.34|P-value:5.24E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:3.46|P-value:2.84E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.27|P-value:5.57E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.29|P-value:5.16E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.51|P-value:2.26E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.64|P-value:1.42E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.78|P-value:9.27E-7 ID:SGTC_1847|Compound:st056231|FD-Score:3.49|P-value:2.51E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.13|P-value:8.73E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.11|P-value:9.91E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.17|P-value:7.83E-4 ID:SGTC_1969|Compound:st069479|FD-Score:-3.38|P-value:3.57E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.96|P-value:3.98E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.32|P-value:4.78E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.66|P-value:1.33E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.21|P-value:6.83E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.36|P-value:4.12E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.55|P-value:2.06E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.68|P-value:1.25E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.37|P-value:3.89E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.10|P-value:2.11E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-3.12|P-value:9.16E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.24|P-value:9.01E-8 ID:SGTC_3213|Compound:9129884|FD-Score:-3.37|P-value:3.80E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.34|P-value:7.13E-6 ID:SGTC_3271|Compound:9137798|FD-Score:-4.12|P-value:1.91E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.91|P-value:4.84E-7 ID:SGTC_3274|Compound:9138298|FD-Score:7.73|P-value:6.43E-15

Top fitness defect scores for YHR177W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3274 9138298 7.73 49.5 µM 6.43E-15 1 5.43E-15
2 SGTC_785 1270-0111 5.34 65.3 µM 5.24E-8 4 4.77E-8
3 SGTC_3201 9113999 5.24 49.5 µM 9.01E-8 10 8.23E-8
4 SGTC_3272 9137413 4.91 49.5 µM 4.84E-7 4 4.45E-7
5 SGTC_1782 st039423 4.78 80.6 µM 9.27E-7 9 8.56E-7
6 SGTC_588 3970-1144 4.65 52.9 µM 1.80E-6 16 1.67E-6
7 SGTC_675 1309-0189 3.96 238.0 µM 3.96E-5 13 3.73E-5
8 SGTC_2059 5238311 3.96 157.0 µM 3.98E-5 27 3.75E-5
9 SGTC_458 nppb 3.75 133.0 µM 9.36E-5 15 8.86E-5
10 SGTC_779 1360-0071 3.73 233.0 µM 9.93E-5 fatty acid desaturase (OLE1) 37 9.39E-5
11 SGTC_592 k241-0073 3.73 46.5 µM 1.02E-4 24 9.63E-5
12 SGTC_1945 st075991 3.73 56.6 µM 1.02E-4 60S ribosome export 26 9.63E-5
13 SGTC_748 0136-0228 3.71 77.9 µM 1.09E-4 redox potentiating 85 1.03E-4
14 SGTC_2759 disulfiram 3.68 3.4 µM 1.25E-4 47 1.18E-4
15 SGTC_150 3970-0969 3.66 77.2 µM 1.31E-4 76 1.24E-4
16 SGTC_2136 5328288 3.66 199.3 µM 1.33E-4 25 1.26E-4
17 SGTC_1781 st038725 3.64 66.3 µM 1.42E-4 NEO1 115 1.34E-4
18 SGTC_513 4245-1575 3.59 41.7 µM 1.76E-4 unfolded protein response 131 1.67E-4
19 SGTC_2721 ifenprodil 3.55 61.4 µM 2.06E-4 plasma membrane duress 33 1.95E-4
20 SGTC_2332 7982454 3.50 138.9 µM 2.42E-4 73 2.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.53E-12 YJL202C_d YJL202C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
0.113 6.21E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.108 3.87E-10 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.103 2.53E-9 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.102 2.71E-9 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.094 5.34E-8 YOL109W ZEO1 hom Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
0.093 6.86E-8 YBL102W SFT2 hom Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
0.088 3.42E-7 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.087 5.09E-7 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 7.46E-7 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
0.081 2.72E-6 YMR082C_d YMR082C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.96E-6 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.079 5.23E-6 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.077 7.66E-6 YDR017C KCS1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
0.077 9.04E-6 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation