YHR178W / STB5

Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR178W / STB5

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:-3.71|P-value:2.33E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.67|P-value:2.66E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.90|P-value:1.75E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.57|P-value:3.81E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.45|P-value:9.06E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:3.87|P-value:9.55E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.30|P-value:9.46E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.69|P-value:1.86E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.15|P-value:4.44E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:-6.44|P-value:5.03E-10 ID:SGTC_752|Compound:1896-0090|FD-Score:4.84|P-value:1.63E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:4.03|P-value:5.03E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:6.05|P-value:3.11E-9 ID:SGTC_953|Compound:1188-0045|FD-Score:3.34|P-value:6.23E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.10|P-value:3.95E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.37|P-value:7.45E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.08|P-value:4.12E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.04|P-value:4.86E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.26|P-value:8.07E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.05|P-value:6.54E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.65|P-value:2.11E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.76|P-value:1.42E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.27|P-value:7.95E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.39|P-value:1.16E-5 ID:SGTC_1700|Compound:st030840|FD-Score:4.09|P-value:3.98E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.89|P-value:8.92E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-3.70|P-value:2.39E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-5.32|P-value:2.41E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.97|P-value:8.81E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.42|P-value:4.78E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.70|P-value:1.77E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.77|P-value:1.37E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.31|P-value:2.31E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.45|P-value:5.77E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.25|P-value:2.92E-5 ID:SGTC_3075|Compound:9116269|FD-Score:4.12|P-value:3.63E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.43|P-value:6.07E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.71|P-value:2.33E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.67|P-value:2.66E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.90|P-value:1.75E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.57|P-value:3.81E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.45|P-value:9.06E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:3.87|P-value:9.55E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.30|P-value:9.46E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.69|P-value:1.86E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.15|P-value:4.44E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:-6.44|P-value:5.03E-10 ID:SGTC_752|Compound:1896-0090|FD-Score:4.84|P-value:1.63E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:4.03|P-value:5.03E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:6.05|P-value:3.11E-9 ID:SGTC_953|Compound:1188-0045|FD-Score:3.34|P-value:6.23E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.84|P-value:1.06E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.10|P-value:3.95E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.37|P-value:7.45E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.08|P-value:4.12E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.04|P-value:4.86E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.26|P-value:8.07E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.05|P-value:6.54E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.65|P-value:2.11E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.76|P-value:1.42E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.27|P-value:7.95E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.39|P-value:1.16E-5 ID:SGTC_1700|Compound:st030840|FD-Score:4.09|P-value:3.98E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.89|P-value:8.92E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-3.70|P-value:2.39E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-5.32|P-value:2.41E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.97|P-value:8.81E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.42|P-value:4.78E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.70|P-value:1.77E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.77|P-value:1.37E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.31|P-value:2.31E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.45|P-value:5.77E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.25|P-value:2.92E-5 ID:SGTC_3075|Compound:9116269|FD-Score:4.12|P-value:3.63E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.43|P-value:6.07E-4

Top fitness defect scores for YHR178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_885 0865-0106 6.05 16.8 µM 3.11E-9 TSC3-RPN4 8 7.30E-10
2 SGTC_752 1896-0090 4.84 130.0 µM 1.63E-6 TSC3-RPN4 6 6.61E-7
3 SGTC_513 4245-1575 4.45 41.7 µM 9.06E-6 unfolded protein response 93 4.27E-6
4 SGTC_1556 plumbagin 4.39 1.5 µM 1.16E-5 superoxide 14 5.59E-6
5 SGTC_3075 9116269 4.12 49.5 µM 3.63E-5 17 1.92E-5
6 SGTC_1064 honokiol 4.10 6.8 µM 3.95E-5 21 2.10E-5
7 SGTC_1700 st030840 4.09 7.9 µM 3.98E-5 PDR1 20 2.12E-5
8 SGTC_1186 1319-0216 4.08 26.0 µM 4.12E-5 18 2.20E-5
9 SGTC_1198 1612-1005 4.04 86.7 µM 4.86E-5 11 2.63E-5
10 SGTC_762 1165-0429 4.03 115.0 µM 5.03E-5 TSC3-RPN4 15 2.73E-5
11 SGTC_1701 st028638 3.89 40.4 µM 8.92E-5 15 5.08E-5
12 SGTC_548 1436-0017 3.87 110.0 µM 9.55E-5 TSC3-RPN4 39 5.48E-5
13 SGTC_972 1319-0219 3.84 195.0 µM 1.06E-4 31 6.15E-5
14 SGTC_2762 leflunomide 3.77 42.1 µM 1.37E-4 40 8.11E-5
15 SGTC_1552 6-methylflavone 3.76 10.6 µM 1.42E-4 superoxide 19 8.42E-5
16 SGTC_2502 avocadyne acetate 3.70 18.6 µM 1.77E-4 34 1.07E-4
17 SGTC_738 1315-0003 3.69 72.4 µM 1.86E-4 33 1.12E-4
18 SGTC_1218 1348-1416 3.65 30.7 µM 2.11E-4 SWF1 & branched chain AA biosynthesis 23 1.29E-4
19 SGTC_2498 4'-Methoxychalcone 3.42 54.6 µM 4.78E-4 RPP1 & pyrimidine depletion 51 3.13E-4
20 SGTC_953 1188-0045 3.34 9.7 µM 6.23E-4 60S ribosome export 49 4.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 3.78E-13 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.121 2.73E-12 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.096 3.08E-8 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.093 7.50E-8 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.090 2.26E-7 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.084 1.78E-6 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.083 1.51E-6 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.081 2.71E-6 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.080 3.40E-6 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.080 3.69E-6 YIR006C PAN1 het Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease
0.080 4.30E-6 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.079 4.53E-6 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.079 4.79E-6 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.079 5.50E-6 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.078 7.38E-6 YBR133C HSL7 hom Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress