YHR179W / OYE2

Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR179W / OYE2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.92|P-value:2.68E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.36|P-value:3.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.08|P-value:8.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.47|P-value:1.54E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.21|P-value:9.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.65|P-value:1.10E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.98|P-value:2.00E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:8.15|P-value:3.89E-17 ID:SGTC_158|Compound:k038-0087|FD-Score:5.95|P-value:6.58E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:3.52|P-value:1.73E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.84|P-value:4.22E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:6.55|P-value:1.12E-11 ID:SGTC_214|Compound:4373-3496|FD-Score:4.33|P-value:5.17E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.96|P-value:2.90E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.01|P-value:8.50E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.30|P-value:2.94E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.47|P-value:2.18E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.55|P-value:1.58E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.35|P-value:3.33E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.32|P-value:2.78E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.06|P-value:1.85E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.44|P-value:2.40E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.26|P-value:3.46E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.51|P-value:1.83E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.37|P-value:4.30E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.06|P-value:9.71E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.58|P-value:1.38E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.42|P-value:2.60E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.68|P-value:9.24E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.69|P-value:8.76E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.41|P-value:2.65E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.57|P-value:1.46E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:7.21|P-value:9.19E-14 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.74|P-value:7.10E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.16|P-value:6.86E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:8.93|P-value:3.43E-20 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.72|P-value:7.71E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.27|P-value:6.84E-6 ID:SGTC_1518|Compound:st038567|FD-Score:3.08|P-value:8.90E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.21|P-value:5.76E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.23|P-value:5.23E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.31|P-value:3.88E-4 ID:SGTC_1711|Compound:st032263|FD-Score:6.73|P-value:3.22E-12 ID:SGTC_1735|Compound:st034310|FD-Score:3.07|P-value:9.31E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.58|P-value:1.56E-6 ID:SGTC_1798|Compound:st045719|FD-Score:3.05|P-value:9.88E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.46|P-value:2.79E-6 ID:SGTC_1932|Compound:st074806|FD-Score:4.40|P-value:3.71E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.77|P-value:6.38E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.40|P-value:2.83E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.78|P-value:6.10E-5 ID:SGTC_2313|Compound:7726885|FD-Score:6.18|P-value:1.46E-10 ID:SGTC_2396|Compound:5342950|FD-Score:3.27|P-value:4.52E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.34|P-value:3.52E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.35|P-value:3.38E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.02|P-value:8.34E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.57|P-value:1.45E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.36|P-value:3.26E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.90|P-value:8.61E-10 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.19|P-value:6.12E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.31|P-value:3.94E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.08|P-value:6.79E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.15|P-value:6.97E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.48|P-value:1.50E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.28|P-value:3.25E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.59|P-value:1.36E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.06|P-value:9.63E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.59|P-value:1.34E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.24|P-value:7.90E-6 ID:SGTC_3017|Compound:9080681|FD-Score:3.90|P-value:3.76E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.74|P-value:7.32E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.58|P-value:1.39E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.28|P-value:6.56E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.99|P-value:2.53E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-3.93|P-value:2.23E-5 ID:SGTC_3075|Compound:9116269|FD-Score:-3.40|P-value:2.05E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.91|P-value:3.57E-5 ID:SGTC_3077|Compound:9117319|FD-Score:5.36|P-value:2.36E-8 ID:SGTC_3103|Compound:9120822|FD-Score:3.12|P-value:7.88E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-4.56|P-value:1.13E-6 ID:SGTC_3137|Compound:9097352|FD-Score:5.26|P-value:4.16E-8 ID:SGTC_3315|Compound:9136395|FD-Score:3.15|P-value:6.96E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.11|P-value:8.14E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.92|P-value:2.68E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.36|P-value:3.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.08|P-value:8.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.47|P-value:1.54E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.21|P-value:9.07E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.65|P-value:1.10E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.98|P-value:2.00E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:8.15|P-value:3.89E-17 ID:SGTC_158|Compound:k038-0087|FD-Score:5.95|P-value:6.58E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:3.52|P-value:1.73E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.84|P-value:4.22E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:6.55|P-value:1.12E-11 ID:SGTC_214|Compound:4373-3496|FD-Score:4.33|P-value:5.17E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.96|P-value:2.90E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.01|P-value:8.50E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.30|P-value:2.94E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.47|P-value:2.18E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.55|P-value:1.58E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.35|P-value:3.33E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.32|P-value:2.78E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.06|P-value:1.85E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.44|P-value:2.40E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.26|P-value:3.46E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.51|P-value:1.83E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.37|P-value:4.30E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:3.48|P-value:2.08E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.06|P-value:9.71E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.58|P-value:1.38E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.42|P-value:2.60E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.68|P-value:9.24E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.69|P-value:8.76E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.41|P-value:2.65E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.57|P-value:1.46E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:7.21|P-value:9.19E-14 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.74|P-value:7.10E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.16|P-value:6.86E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:8.93|P-value:3.43E-20 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.72|P-value:7.71E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.27|P-value:6.84E-6 ID:SGTC_1518|Compound:st038567|FD-Score:3.08|P-value:8.90E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.21|P-value:5.76E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.23|P-value:5.23E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.31|P-value:3.88E-4 ID:SGTC_1711|Compound:st032263|FD-Score:6.73|P-value:3.22E-12 ID:SGTC_1735|Compound:st034310|FD-Score:3.07|P-value:9.31E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.58|P-value:1.56E-6 ID:SGTC_1798|Compound:st045719|FD-Score:3.05|P-value:9.88E-4 ID:SGTC_1799|Compound:st045822|FD-Score:4.46|P-value:2.79E-6 ID:SGTC_1932|Compound:st074806|FD-Score:4.40|P-value:3.71E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.77|P-value:6.38E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.40|P-value:2.83E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.78|P-value:6.10E-5 ID:SGTC_2313|Compound:7726885|FD-Score:6.18|P-value:1.46E-10 ID:SGTC_2396|Compound:5342950|FD-Score:3.27|P-value:4.52E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.34|P-value:3.52E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.35|P-value:3.38E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.02|P-value:8.34E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.57|P-value:1.45E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.36|P-value:3.26E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.90|P-value:8.61E-10 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.19|P-value:6.12E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.31|P-value:3.94E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.08|P-value:6.79E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.15|P-value:6.97E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.48|P-value:1.50E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.28|P-value:3.25E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.59|P-value:1.36E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.06|P-value:9.63E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.59|P-value:1.34E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.24|P-value:7.90E-6 ID:SGTC_3017|Compound:9080681|FD-Score:3.90|P-value:3.76E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.74|P-value:7.32E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.58|P-value:1.39E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.28|P-value:6.56E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.99|P-value:2.53E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-3.93|P-value:2.23E-5 ID:SGTC_3075|Compound:9116269|FD-Score:-3.40|P-value:2.05E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.91|P-value:3.57E-5 ID:SGTC_3077|Compound:9117319|FD-Score:5.36|P-value:2.36E-8 ID:SGTC_3103|Compound:9120822|FD-Score:3.12|P-value:7.88E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-4.56|P-value:1.13E-6 ID:SGTC_3137|Compound:9097352|FD-Score:5.26|P-value:4.16E-8 ID:SGTC_3315|Compound:9136395|FD-Score:3.15|P-value:6.96E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.11|P-value:8.14E-4

Top fitness defect scores for YHR179W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1482 3346-2049 8.93 8.5 µM 3.43E-20 10 2.17E-19
2 SGTC_150 3970-0969 8.15 77.2 µM 3.89E-17 6 1.76E-16
3 SGTC_1294 1000-1494 7.21 117.0 µM 9.19E-14 15 2.89E-13
4 SGTC_1711 st032263 6.73 62.8 µM 3.22E-12 3 8.61E-12
5 SGTC_212 3807-4682 6.55 38.8 µM 1.12E-11 tubulin folding & SWR complex 22 2.82E-11
6 SGTC_2313 7726885 6.18 200.0 µM 1.46E-10 RPP1 & pyrimidine depletion 4 3.28E-10
7 SGTC_158 k038-0087 5.95 26.4 µM 6.58E-10 ubiquinone biosynthesis & proteasome 69 1.38E-9
8 SGTC_2544 sphondin 5.90 68.5 µM 8.61E-10 RNA pol III & RNase P/MRP 7 1.78E-9
9 SGTC_3077 9117319 5.36 49.5 µM 2.36E-8 4 4.22E-8
10 SGTC_3137 9097352 5.26 49.5 µM 4.16E-8 15 7.25E-8
11 SGTC_149 3970-0822 4.98 46.1 µM 2.00E-7 tubulin folding & SWR complex 49 3.25E-7
12 SGTC_58 0957-0393 4.92 9.0 µM 2.68E-7 cell wall 292 4.30E-7
13 SGTC_210 3551-0445 4.84 56.8 µM 4.22E-7 40 6.65E-7
14 SGTC_1331 1472-0049 4.74 76.2 µM 7.10E-7 5 1.09E-6
15 SGTC_1498 4478-3555 4.72 97.6 µM 7.71E-7 2 1.18E-6
16 SGTC_1161 k007-0610 4.69 110.0 µM 8.76E-7 ERAD & cell cycle 89 1.34E-6
17 SGTC_138 0850-0259 4.65 40.9 µM 1.10E-6 cell wall 158 1.67E-6
18 SGTC_1750 st081859 4.58 2.4 µM 1.56E-6 endomembrane recycling 149 2.32E-6
19 SGTC_1799 st045822 4.46 46.1 µM 2.79E-6 5 4.05E-6
20 SGTC_1932 st074806 4.40 40.9 µM 3.71E-6 16 5.32E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 6.67E-103 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.313 4.85E-77 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.311 5.84E-76 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.303 2.64E-72 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.301 2.47E-71 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.301 2.98E-71 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.293 1.99E-67 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.290 8.21E-66 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.256 2.00E-51 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.255 7.06E-51 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.253 5.65E-50 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.212 1.90E-35 YNL136W EAF7 hom Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
0.192 3.53E-29 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.184 4.99E-27 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.183 1.33E-26 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export