YHR180W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR180W / YHR180W

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-3.48|P-value:1.21E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.98|P-value:8.36E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.25|P-value:2.91E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.68|P-value:5.00E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.36|P-value:1.91E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.67|P-value:5.28E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.76|P-value:3.52E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:2.99|P-value:7.87E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.03|P-value:6.93E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.28|P-value:2.72E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.05|P-value:6.32E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.48|P-value:1.14E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.11|P-value:5.05E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.35|P-value:2.01E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.31|P-value:2.73E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:2.94|P-value:9.51E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.33|P-value:2.21E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-5.77|P-value:5.56E-10 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.23|P-value:3.97E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:-4.07|P-value:8.65E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:3.14|P-value:4.41E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.22|P-value:3.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:7.90|P-value:3.35E-17 ID:SGTC_1080|Compound:nisoldipine|FD-Score:6.32|P-value:1.16E-11 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.29|P-value:2.88E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.94|P-value:1.60E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.18|P-value:3.90E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.27|P-value:2.72E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.48|P-value:3.51E-9 ID:SGTC_1702|Compound:st027038|FD-Score:2.95|P-value:9.00E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.02|P-value:6.89E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.74|P-value:4.00E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.85|P-value:2.40E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.07|P-value:8.39E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.24|P-value:3.13E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.10|P-value:5.28E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.57|P-value:7.82E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-4.54|P-value:8.25E-7 ID:SGTC_2290|Compound:7904846|FD-Score:-3.56|P-value:8.66E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.57|P-value:8.02E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.10|P-value:5.25E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.79|P-value:3.18E-5 ID:SGTC_2831|Compound:7999036|FD-Score:2.92|P-value:9.96E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-4.15|P-value:5.93E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-3.04|P-value:6.58E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.00|P-value:7.55E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.48|P-value:1.21E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.98|P-value:8.36E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.25|P-value:2.91E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.68|P-value:5.00E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.36|P-value:1.91E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.67|P-value:5.28E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.76|P-value:3.52E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:2.99|P-value:7.87E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.03|P-value:6.93E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.28|P-value:2.72E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.05|P-value:6.32E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.48|P-value:1.14E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.11|P-value:5.05E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.35|P-value:2.01E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.31|P-value:2.73E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:2.94|P-value:9.51E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.33|P-value:2.21E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-5.77|P-value:5.56E-10 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.23|P-value:3.97E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:-4.07|P-value:8.65E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:3.14|P-value:4.41E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.22|P-value:3.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:7.90|P-value:3.35E-17 ID:SGTC_1080|Compound:nisoldipine|FD-Score:6.32|P-value:1.16E-11 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.29|P-value:2.88E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.94|P-value:1.60E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.18|P-value:3.90E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.27|P-value:2.72E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.48|P-value:3.51E-9 ID:SGTC_1702|Compound:st027038|FD-Score:2.95|P-value:9.00E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.02|P-value:6.89E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.74|P-value:4.00E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.85|P-value:2.40E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.07|P-value:8.39E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.24|P-value:3.13E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.10|P-value:5.28E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.57|P-value:7.82E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-4.54|P-value:8.25E-7 ID:SGTC_2290|Compound:7904846|FD-Score:-3.56|P-value:8.66E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.57|P-value:8.02E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.10|P-value:5.25E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.79|P-value:3.18E-5 ID:SGTC_2831|Compound:7999036|FD-Score:2.92|P-value:9.96E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-4.15|P-value:5.93E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-3.04|P-value:6.58E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.00|P-value:7.55E-4

Top fitness defect scores for YHR180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 7.90 1.8 µM 3.35E-17 22 1.38E-15
2 SGTC_1080 nisoldipine 6.32 24.4 µM 1.16E-11 TSC3-RPN4 3 1.28E-10
3 SGTC_1457 k015-0032 5.48 57.3 µM 3.51E-9 11 2.17E-8
4 SGTC_2126 5251174 4.07 33.9 µM 8.39E-6 28 2.35E-5
5 SGTC_424 splitomicin 3.76 100.0 mM 3.52E-5 26 8.54E-5
6 SGTC_372 0155-0182 3.67 15.9 µM 5.28E-5 mitochondrial response to ROS 35 1.23E-4
7 SGTC_2284 7945075 3.57 39.2 µM 7.82E-5 mitochondrial processes 37 1.75E-4
8 SGTC_1211 1056-0033 3.49 32.3 µM 1.13E-4 19 2.44E-4
9 SGTC_651 3253-0966 3.48 34.4 µM 1.14E-4 calcium & mitochondrial duress 47 2.46E-4
10 SGTC_1174 0739-0097 3.44 51.1 µM 1.40E-4 redox potentiating 51 2.96E-4
11 SGTC_307 1501-1223 3.36 22.3 µM 1.91E-4 20 3.91E-4
12 SGTC_1212 0520-0165 3.27 585.0 µM 2.72E-4 63 5.39E-4
13 SGTC_188 3229-0966 3.25 278.5 µM 2.91E-4 64 5.72E-4
14 SGTC_877 0771-0151 3.22 33.1 µM 3.31E-4 30 6.43E-4
15 SGTC_1208 2323-2347 3.18 50.3 µM 3.90E-4 31 7.45E-4
16 SGTC_875 0709-0210 3.14 25.7 µM 4.41E-4 fatty acid desaturase (OLE1) 63 8.33E-4
17 SGTC_779 1360-0071 3.11 233.0 µM 5.05E-4 fatty acid desaturase (OLE1) 70 9.41E-4
18 SGTC_2255 7941087 3.10 197.4 µM 5.28E-4 69 9.79E-4
19 SGTC_1718 roemerine 3.02 11.9 µM 6.89E-4 redox potentiating 119 0.00125
20 SGTC_3315 9136395 3.00 68.5 µM 7.55E-4 41 0.00135

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 3.26E-63 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.252 1.12E-49 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.200 1.17E-31 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.191 7.56E-29 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.188 3.52E-28 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.184 4.80E-27 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.184 5.90E-27 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.180 6.22E-26 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.180 7.59E-26 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.172 8.75E-24 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.155 2.04E-19 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.154 3.64E-19 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.146 2.27E-17 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.144 4.66E-17 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.141 2.13E-16 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking