YHR183W / GND1

6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR183W / GND1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.22|P-value:8.15E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.71|P-value:1.51E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-8.30|P-value:9.71E-16 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.39|P-value:6.42E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.63|P-value:3.35E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.67|P-value:1.72E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.21|P-value:8.42E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-5.08|P-value:6.36E-7 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.84|P-value:9.15E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.95|P-value:8.81E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.31|P-value:2.01E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.87|P-value:1.15E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.28|P-value:6.88E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.16|P-value:2.58E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.44|P-value:3.96E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.26|P-value:9.95E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.39|P-value:6.57E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.93|P-value:1.29E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.04|P-value:6.04E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.88|P-value:7.68E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.28|P-value:9.32E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.29|P-value:8.92E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.23|P-value:8.11E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.01|P-value:6.99E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-4.63|P-value:5.13E-6 ID:SGTC_1602|Compound:st001878|FD-Score:-5.65|P-value:3.57E-8 ID:SGTC_1616|Compound:st002734|FD-Score:-5.39|P-value:1.34E-7 ID:SGTC_1628|Compound:st004252|FD-Score:-3.30|P-value:8.88E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.34|P-value:5.56E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.69|P-value:1.57E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-5.79|P-value:1.66E-8 ID:SGTC_1766|Compound:st045414|FD-Score:-4.73|P-value:3.31E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.37|P-value:7.01E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.29|P-value:6.49E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.85|P-value:8.65E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.36|P-value:7.28E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.56|P-value:3.59E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.98|P-value:5.22E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-4.56|P-value:7.09E-6 ID:SGTC_2303|Compound:7774051|FD-Score:3.83|P-value:9.61E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.82|P-value:9.69E-5 ID:SGTC_2393|Compound:9031399|FD-Score:4.01|P-value:4.66E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.54|P-value:2.76E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.42|P-value:5.90E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.58|P-value:6.43E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.42|P-value:4.26E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.33|P-value:8.01E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.19|P-value:9.01E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.23|P-value:8.06E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-5.97|P-value:6.05E-9 ID:SGTC_2952|Compound:9073731|FD-Score:3.42|P-value:4.17E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.20|P-value:8.89E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-8.63|P-value:6.97E-17 ID:SGTC_3158|Compound:9100007|FD-Score:4.07|P-value:3.67E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.31|P-value:8.56E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-4.43|P-value:1.23E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-3.56|P-value:3.68E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.22|P-value:8.15E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.71|P-value:1.51E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-8.30|P-value:9.71E-16 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.39|P-value:6.42E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.63|P-value:3.35E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.67|P-value:1.72E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.21|P-value:8.42E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-5.08|P-value:6.36E-7 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.84|P-value:9.15E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.95|P-value:8.81E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.31|P-value:2.01E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.87|P-value:1.15E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.28|P-value:6.88E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.16|P-value:2.58E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.44|P-value:3.96E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.26|P-value:9.95E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.39|P-value:6.57E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.93|P-value:1.29E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.04|P-value:6.04E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.88|P-value:7.68E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.28|P-value:9.32E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.29|P-value:8.92E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.23|P-value:8.11E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.01|P-value:6.99E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-4.63|P-value:5.13E-6 ID:SGTC_1602|Compound:st001878|FD-Score:-5.65|P-value:3.57E-8 ID:SGTC_1616|Compound:st002734|FD-Score:-5.39|P-value:1.34E-7 ID:SGTC_1628|Compound:st004252|FD-Score:-3.30|P-value:8.88E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.34|P-value:5.56E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.69|P-value:1.57E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-5.79|P-value:1.66E-8 ID:SGTC_1766|Compound:st045414|FD-Score:-4.73|P-value:3.31E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.37|P-value:7.01E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.29|P-value:6.49E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.85|P-value:8.65E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.36|P-value:7.28E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.56|P-value:3.59E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.98|P-value:5.22E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-4.56|P-value:7.09E-6 ID:SGTC_2303|Compound:7774051|FD-Score:3.83|P-value:9.61E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.82|P-value:9.69E-5 ID:SGTC_2393|Compound:9031399|FD-Score:4.01|P-value:4.66E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.54|P-value:2.76E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.42|P-value:5.90E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.58|P-value:6.43E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.42|P-value:4.26E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.33|P-value:8.01E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.19|P-value:9.01E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.23|P-value:8.06E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-5.97|P-value:6.05E-9 ID:SGTC_2952|Compound:9073731|FD-Score:3.42|P-value:4.17E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.20|P-value:8.89E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-8.63|P-value:6.97E-17 ID:SGTC_3158|Compound:9100007|FD-Score:4.07|P-value:3.67E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.31|P-value:8.56E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-4.43|P-value:1.23E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-3.56|P-value:3.68E-4

Top fitness defect scores for YHR183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_69 0096-0274 4.63 206.7 µM 3.35E-6 mitochondrial processes 26 1.83E-6
2 SGTC_577 r071-0003 4.16 38.6 µM 2.58E-5 fatty acid desaturase (OLE1) 46 1.61E-5
3 SGTC_3158 9100007 4.07 49.5 µM 3.67E-5 17 2.34E-5
4 SGTC_2393 9031399 4.01 185.9 µM 4.66E-5 RNA processing & uracil transport 24 3.02E-5
5 SGTC_2223 6903751 3.98 107.6 µM 5.22E-5 superoxide 10 3.41E-5
6 SGTC_1354 1498-1681 3.88 81.0 µM 7.68E-5 22 5.13E-5
7 SGTC_1969 st069479 3.85 40.1 µM 8.65E-5 13 5.83E-5
8 SGTC_272 doxorubicin 3.84 8.1 µM 9.15E-5 anthracycline transcription coupled DNA repair 24 6.19E-5
9 SGTC_2303 7774051 3.83 200.0 µM 9.61E-5 22 6.52E-5
10 SGTC_2358 9037157 3.82 4.0 µM 9.69E-5 36 6.57E-5
11 SGTC_20 0481-0013 3.71 4.9 µM 1.51E-4 31 1.06E-4
12 SGTC_1661 st013063 3.69 9.7 µM 1.57E-4 31 1.10E-4
13 SGTC_100 0086-0128 3.67 49.6 µM 1.72E-4 copper-dependent oxidative stress 62 1.21E-4
14 SGTC_2139 5578692 3.63 56.5 µM 1.97E-4 superoxide 21 1.40E-4
15 SGTC_2845 9003024 3.62 43.0 µM 2.07E-4 amide catabolism 56 1.47E-4
16 SGTC_2408 sulbentine 3.54 18.4 µM 2.76E-4 63 2.00E-4
17 SGTC_581 0958-0271 3.44 211.0 µM 3.96E-4 73 2.93E-4
18 SGTC_2952 9073731 3.42 13.8 µM 4.17E-4 tubulin folding & SWR complex 67 3.10E-4
19 SGTC_2578 7,8-dihydroxyflavone 3.42 64.4 µM 4.26E-4 55 3.17E-4
20 SGTC_1633 st005664 3.34 67.9 µM 5.56E-4 61 4.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.85E-10 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.098 1.31E-8 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.097 2.06E-8 YMR075C-A_d YMR075C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W
0.093 7.44E-8 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.091 1.28E-7 YPL080C_d YPL080C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.34E-7 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.089 2.84E-7 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.087 5.28E-7 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.086 6.56E-7 YPR187W RPO26 het RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
0.082 1.95E-6 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.081 2.40E-6 YIL043C CBR1 hom Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
0.080 3.88E-6 YJL176C SWI3 hom Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions
0.079 4.83E-6 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.078 5.69E-6 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.078 6.44E-6 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3