YHR184W / SSP1

Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR184W / SSP1

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:4.55|P-value:2.16E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:3.14|P-value:7.68E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.41|P-value:4.28E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:3.92|P-value:3.80E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.17|P-value:6.52E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.58|P-value:1.42E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.10|P-value:8.21E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.90|P-value:3.77E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.69|P-value:9.21E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.94|P-value:3.21E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.38|P-value:4.84E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.83|P-value:5.56E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.28|P-value:7.77E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.20|P-value:6.23E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.54|P-value:2.33E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.30|P-value:4.32E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.08|P-value:9.49E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.73|P-value:8.91E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.07|P-value:9.88E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.79|P-value:6.02E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.46|P-value:2.27E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.21|P-value:6.10E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.56|P-value:2.11E-6 ID:SGTC_2001|Compound:4023502|FD-Score:4.29|P-value:7.36E-6 ID:SGTC_2024|Compound:5144227|FD-Score:4.93|P-value:3.27E-7 ID:SGTC_2068|Compound:5226020|FD-Score:4.74|P-value:8.63E-7 ID:SGTC_2171|Compound:5739187|FD-Score:4.93|P-value:3.15E-7 ID:SGTC_2179|Compound:6298986|FD-Score:-3.27|P-value:4.46E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.12|P-value:8.17E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.88|P-value:4.50E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.44|P-value:2.63E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.57|P-value:1.55E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.58|P-value:1.86E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.89|P-value:3.99E-7 ID:SGTC_2931|Compound:9014674|FD-Score:-3.83|P-value:5.01E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-4.18|P-value:1.14E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.58|P-value:1.53E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.58|P-value:1.52E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.92|P-value:3.87E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.10|P-value:8.32E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.71|P-value:9.76E-7 ID:SGTC_3110|Compound:9122132|FD-Score:4.29|P-value:7.26E-6 ID:SGTC_3116|Compound:9124943|FD-Score:4.11|P-value:1.64E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.84|P-value:4.90E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.55|P-value:2.16E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:3.14|P-value:7.68E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.41|P-value:4.28E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:3.92|P-value:3.80E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.17|P-value:6.52E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.58|P-value:1.42E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.10|P-value:8.21E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.90|P-value:3.77E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.69|P-value:9.21E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.94|P-value:3.21E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.38|P-value:4.84E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.83|P-value:5.56E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.28|P-value:7.77E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.20|P-value:6.23E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.54|P-value:2.33E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.30|P-value:4.32E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.08|P-value:9.49E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.73|P-value:8.91E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.07|P-value:9.88E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.79|P-value:6.02E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.46|P-value:2.27E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.21|P-value:6.10E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.56|P-value:2.11E-6 ID:SGTC_2001|Compound:4023502|FD-Score:4.29|P-value:7.36E-6 ID:SGTC_2024|Compound:5144227|FD-Score:4.93|P-value:3.27E-7 ID:SGTC_2068|Compound:5226020|FD-Score:4.74|P-value:8.63E-7 ID:SGTC_2171|Compound:5739187|FD-Score:4.93|P-value:3.15E-7 ID:SGTC_2179|Compound:6298986|FD-Score:-3.27|P-value:4.46E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.12|P-value:8.17E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.88|P-value:4.50E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.44|P-value:2.63E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.57|P-value:1.55E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.58|P-value:1.86E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.89|P-value:3.99E-7 ID:SGTC_2931|Compound:9014674|FD-Score:-3.83|P-value:5.01E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-4.18|P-value:1.14E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.58|P-value:1.53E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.58|P-value:1.52E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.92|P-value:3.87E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.10|P-value:8.32E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.71|P-value:9.76E-7 ID:SGTC_3110|Compound:9122132|FD-Score:4.29|P-value:7.26E-6 ID:SGTC_3116|Compound:9124943|FD-Score:4.11|P-value:1.64E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.84|P-value:4.90E-5

Top fitness defect scores for YHR184W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2171 5739187 4.93 198.1 µM 3.15E-7 copper-dependent oxidative stress 7 4.06E-7
2 SGTC_2024 5144227 4.93 134.0 µM 3.27E-7 16 4.21E-7
3 SGTC_2591 skatole 4.89 100.0 µM 3.99E-7 12 5.11E-7
4 SGTC_2068 5226020 4.74 147.0 µM 8.63E-7 14 1.09E-6
5 SGTC_1199 1638-0010 4.73 4.5 µM 8.91E-7 endomembrane recycling 7 1.12E-6
6 SGTC_3108 9121785 4.71 49.5 µM 9.76E-7 3 1.23E-6
7 SGTC_2533 agelasine 4.58 13.7 µM 1.86E-6 ERG2 33 2.31E-6
8 SGTC_1841 st054148 4.56 70.0 µM 2.11E-6 4 2.61E-6
9 SGTC_93 0109-0045 4.55 59.2 µM 2.16E-6 DNA damage response 25 2.68E-6
10 SGTC_1022 4477-0945 4.54 21.3 µM 2.33E-6 12 2.87E-6
11 SGTC_168 3970-0862 4.41 530.5 µM 4.28E-6 93 5.22E-6
12 SGTC_772 k072-0172 4.38 35.3 µM 4.84E-6 12 5.89E-6
13 SGTC_3110 9122132 4.29 49.5 µM 7.26E-6 redox potentiating 17 8.77E-6
14 SGTC_2001 4023502 4.29 57.7 µM 7.36E-6 mitochondrial processes 10 8.88E-6
15 SGTC_950 1165-0508 4.28 94.1 µM 7.77E-6 20 9.37E-6
16 SGTC_3116 9124943 4.11 49.5 µM 1.64E-5 13 1.94E-5
17 SGTC_372 0155-0182 4.11 15.9 µM 1.69E-5 mitochondrial response to ROS 27 2.00E-5
18 SGTC_343 4130-2827 3.92 29.8 µM 3.80E-5 34 4.44E-5
19 SGTC_3030 9087619 3.92 49.5 µM 3.87E-5 10 4.52E-5
20 SGTC_2311 7694451 3.88 200.0 µM 4.50E-5 18 5.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.47E-9 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.099 7.96E-9 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.090 1.73E-7 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.079 5.17E-6 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.078 5.33E-6 YPL105C SYH1 hom Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication
0.078 6.86E-6 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.077 7.44E-6 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.075 1.43E-5 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.073 2.51E-5 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.071 3.70E-5 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.071 4.13E-5 YIL050W PCL7 hom Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
0.071 4.41E-5 YOR323C PRO2 hom Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
0.070 4.45E-5 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.070 4.64E-5 YGR243W FMP43 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress
0.068 7.82E-5 YNL025C SSN8 hom Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance