HIPHOP chemogenomics database
YHR184W / SSP1 
Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR184W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.104 | 1.47E-9 | YML025C | YML6 | het | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |
| 0.099 | 7.96E-9 | YNL123W | NMA111 | hom | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
| 0.090 | 1.73E-7 | YJL101C | GSH1 | hom | Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress |
| 0.079 | 5.17E-6 | YJR124C_p | YJR124C_p | hom | Putative protein of unknown function; expression induced under calcium shortage |
| 0.078 | 5.33E-6 | YPL105C | SYH1 | hom | Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication |
| 0.078 | 6.86E-6 | YDL108W | KIN28 | het | Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters |
| 0.077 | 7.44E-6 | YLR317W_d | YLR317W_d | het | Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C |
| 0.075 | 1.43E-5 | YHL045W_d | YHL045W_d | hom | Putative protein of unknown function; not an essential gene |
| 0.073 | 2.51E-5 | YML029W | USA1 | hom | Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p |
| 0.071 | 3.70E-5 | YDR225W | HTA1 | hom | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
| 0.071 | 4.13E-5 | YIL050W | PCL7 | hom | Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated |
| 0.071 | 4.41E-5 | YOR323C | PRO2 | hom | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
| 0.070 | 4.45E-5 | YGL114W_p | YGL114W_p | hom | Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters |
| 0.070 | 4.64E-5 | YGR243W | FMP43 | hom | Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress |
| 0.068 | 7.82E-5 | YNL025C | SSN8 | hom | Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance |