YHR188C / GPI16

Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR188C / GPI16

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.06|P-value:2.84E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:2.75|P-value:9.86E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.20|P-value:1.12E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.06|P-value:2.91E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.12|P-value:2.27E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.95|P-value:4.41E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.24|P-value:1.30E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-2.91|P-value:4.98E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.10|P-value:2.42E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.00|P-value:3.71E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.26|P-value:1.24E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.65|P-value:1.98E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.83|P-value:6.80E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:2.89|P-value:5.67E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.04|P-value:3.12E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.08|P-value:2.00E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.97|P-value:4.19E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.97|P-value:3.83E-6 ID:SGTC_1530|Compound:rhein|FD-Score:3.32|P-value:9.27E-5 ID:SGTC_1714|Compound:st033236|FD-Score:2.78|P-value:8.92E-4 ID:SGTC_1923|Compound:st058458|FD-Score:6.06|P-value:4.08E-12 ID:SGTC_1948|Compound:st076329|FD-Score:2.97|P-value:4.14E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.57|P-value:2.87E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.82|P-value:8.44E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.64|P-value:2.11E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.87|P-value:6.27E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.08|P-value:2.63E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-4.11|P-value:1.68E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.93|P-value:4.87E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:2.76|P-value:9.35E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.98|P-value:4.02E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.88|P-value:5.84E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:-3.32|P-value:8.49E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.21|P-value:1.07E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.82|P-value:7.44E-4 ID:SGTC_2879|Compound:9041815|FD-Score:2.92|P-value:5.04E-4 ID:SGTC_3116|Compound:9124943|FD-Score:2.84|P-value:7.01E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.75|P-value:1.10E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.18|P-value:1.58E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.06|P-value:2.84E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:2.75|P-value:9.86E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.20|P-value:1.12E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.06|P-value:2.91E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.12|P-value:2.27E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.95|P-value:4.41E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.24|P-value:1.30E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-2.91|P-value:4.98E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.10|P-value:2.42E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.00|P-value:3.71E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.26|P-value:1.24E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.65|P-value:1.98E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.83|P-value:6.80E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:2.89|P-value:5.67E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.04|P-value:3.12E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.08|P-value:2.00E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.97|P-value:4.19E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.97|P-value:3.83E-6 ID:SGTC_1530|Compound:rhein|FD-Score:3.32|P-value:9.27E-5 ID:SGTC_1714|Compound:st033236|FD-Score:2.78|P-value:8.92E-4 ID:SGTC_1923|Compound:st058458|FD-Score:6.06|P-value:4.08E-12 ID:SGTC_1948|Compound:st076329|FD-Score:2.97|P-value:4.14E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.57|P-value:2.87E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.82|P-value:8.44E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.64|P-value:2.11E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.87|P-value:6.27E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.08|P-value:2.63E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-4.11|P-value:1.68E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.93|P-value:4.87E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:2.76|P-value:9.35E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.98|P-value:4.02E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.88|P-value:5.84E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:-3.32|P-value:8.49E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.21|P-value:1.07E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:2.82|P-value:7.44E-4 ID:SGTC_2879|Compound:9041815|FD-Score:2.92|P-value:5.04E-4 ID:SGTC_3116|Compound:9124943|FD-Score:2.84|P-value:7.01E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.75|P-value:1.10E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.18|P-value:1.58E-4

Top fitness defect scores for YHR188C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1923 st058458 6.06 19.1 µM 4.08E-12 3 6.65E-10 0.92
2 SGTC_2689 tacrolimus 4.21 100.0 µM 1.07E-6 11 1.29E-5 0.09
3 SGTC_497 capsazepine 4.20 133.0 µM 1.12E-6 4 1.34E-5 0.55
4 SGTC_1418 3966-3099 3.97 2.4 µM 3.83E-6 3 3.56E-5 0.22
5 SGTC_2454 5-benzylidenerhodanine 3.93 10.4 µM 4.87E-6 TRP & mitochondrial translation 3 4.31E-5 0.10
6 SGTC_2162 5663267 3.82 200.0 µM 8.44E-6 11 6.67E-5 0.05
7 SGTC_941 3237-0776 3.65 460.0 µM 1.98E-5 6 1.31E-4 0.50
8 SGTC_2321 7390090 3.64 138.8 µM 2.11E-5 7 1.38E-4 0.02
9 SGTC_2115 tiliquinol 3.57 12.8 µM 2.87E-5 5 1.77E-4 0.19
10 SGTC_1530 rhein 3.32 70.4 µM 9.27E-5 4 4.50E-4 0.06
11 SGTC_939 1165-0479 3.26 45.3 µM 1.24E-4 11 5.66E-4 0.10
12 SGTC_645 0845-0943 3.24 5.4 µM 1.30E-4 60S ribosome export 9 5.90E-4 0.02
13 SGTC_535 2293-4129 3.12 48.2 µM 2.27E-4 NEO1 19 9.19E-4 0.05
14 SGTC_740 k014-0057 3.10 261.0 µM 2.42E-4 16 9.68E-4 0.17
15 SGTC_2354 9060492 3.08 162.0 µM 2.63E-4 13 0.00104 0.03
16 SGTC_17 0960-0276 3.06 49.8 µM 2.84E-4 21 0.00110 0.02
17 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.06 150.0 µM 2.91E-4 Golgi 11 0.00112 0.11
18 SGTC_1128 3448-9350 3.04 235.0 µM 3.12E-4 14 0.00119 0.05
19 SGTC_925 2064-1272 3.00 59.6 µM 3.71E-4 18 0.00136 0.01
20 SGTC_2625 euphol 2.98 100.0 µM 4.02E-4 16 0.00145 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 5.56E-30 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.109 2.23E-10 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.106 8.51E-10 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.105 9.58E-10 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.104 1.64E-9 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.098 1.18E-8 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.098 1.49E-8 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.096 2.21E-8 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.096 2.58E-8 YBR051W_d YBR051W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
0.094 4.30E-8 YHR049W FSH1 hom Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
0.093 6.17E-8 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.092 8.60E-8 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.091 1.47E-7 YER148W SPT15 het TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
0.090 1.67E-7 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.082 1.90E-6 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene