YHR189W / PTH1

One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR189W / PTH1

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-4.58|P-value:1.08E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:4.01|P-value:1.75E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.61|P-value:9.73E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.17|P-value:7.72E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-5.49|P-value:6.65E-9 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.12|P-value:6.49E-4 ID:SGTC_480|Compound:am 92016|FD-Score:5.09|P-value:7.67E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:3.15|P-value:5.97E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.96|P-value:2.24E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:8.85|P-value:3.27E-20 ID:SGTC_731|Compound:3966-0296|FD-Score:3.59|P-value:1.06E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.26|P-value:5.56E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-5.10|P-value:6.31E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:3.48|P-value:1.71E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.12|P-value:6.01E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.37|P-value:2.38E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.57|P-value:1.17E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.40|P-value:2.27E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.93|P-value:2.55E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.07|P-value:7.69E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.08|P-value:1.27E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.27|P-value:3.72E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.28|P-value:3.61E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.18|P-value:5.26E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.25|P-value:3.77E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.56|P-value:1.13E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.16|P-value:5.74E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.17|P-value:8.40E-6 ID:SGTC_1751|Compound:st044839|FD-Score:5.24|P-value:3.28E-8 ID:SGTC_1766|Compound:st045414|FD-Score:3.05|P-value:8.45E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.42|P-value:2.11E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.20|P-value:4.91E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.19|P-value:4.99E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.44|P-value:1.82E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-6.24|P-value:5.32E-11 ID:SGTC_2051|Compound:5263410|FD-Score:-5.65|P-value:2.49E-9 ID:SGTC_2058|Compound:5236698|FD-Score:-3.59|P-value:9.83E-5 ID:SGTC_2068|Compound:5226020|FD-Score:4.45|P-value:2.20E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.01|P-value:9.04E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.24|P-value:4.24E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.03|P-value:9.03E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.49|P-value:1.51E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.13|P-value:6.39E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.62|P-value:9.53E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.50|P-value:1.54E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.97|P-value:2.11E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-4.78|P-value:3.79E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.42|P-value:2.14E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.13|P-value:5.86E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.63|P-value:7.98E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:3.44|P-value:1.98E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.70|P-value:6.15E-7 ID:SGTC_2815|Compound:7968870|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.18|P-value:5.22E-4 ID:SGTC_3021|Compound:9087658|FD-Score:5.12|P-value:6.36E-8 ID:SGTC_3029|Compound:9088683|FD-Score:5.46|P-value:9.04E-9 ID:SGTC_3078|Compound:9116413|FD-Score:3.66|P-value:7.95E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.42|P-value:2.09E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.01|P-value:9.57E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_3197|Compound:9113331|FD-Score:4.40|P-value:2.84E-6 ID:SGTC_3198|Compound:9112019|FD-Score:-3.02|P-value:8.85E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.41|P-value:2.20E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.69|P-value:6.66E-7 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.58|P-value:1.08E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:4.01|P-value:1.75E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.61|P-value:9.73E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.17|P-value:7.72E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-5.49|P-value:6.65E-9 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.12|P-value:6.49E-4 ID:SGTC_480|Compound:am 92016|FD-Score:5.09|P-value:7.67E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:3.15|P-value:5.97E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.96|P-value:2.24E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:8.85|P-value:3.27E-20 ID:SGTC_731|Compound:3966-0296|FD-Score:3.59|P-value:1.06E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.26|P-value:5.56E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-5.10|P-value:6.31E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:3.48|P-value:1.71E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.12|P-value:6.01E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.37|P-value:2.38E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.57|P-value:1.17E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.40|P-value:2.27E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.93|P-value:2.55E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.07|P-value:7.69E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.08|P-value:1.27E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.27|P-value:3.72E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.28|P-value:3.61E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.18|P-value:5.26E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.25|P-value:3.77E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.56|P-value:1.13E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.16|P-value:5.74E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.17|P-value:8.40E-6 ID:SGTC_1751|Compound:st044839|FD-Score:5.24|P-value:3.28E-8 ID:SGTC_1766|Compound:st045414|FD-Score:3.05|P-value:8.45E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.42|P-value:2.11E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.20|P-value:4.91E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.19|P-value:4.99E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.44|P-value:1.82E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-6.24|P-value:5.32E-11 ID:SGTC_2051|Compound:5263410|FD-Score:-5.65|P-value:2.49E-9 ID:SGTC_2058|Compound:5236698|FD-Score:-3.59|P-value:9.83E-5 ID:SGTC_2068|Compound:5226020|FD-Score:4.45|P-value:2.20E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.01|P-value:9.04E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.24|P-value:4.24E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.03|P-value:9.03E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.49|P-value:1.51E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.13|P-value:6.39E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.62|P-value:9.53E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.50|P-value:1.54E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.97|P-value:2.11E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-4.78|P-value:3.79E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.42|P-value:2.14E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.13|P-value:5.86E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.63|P-value:7.98E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:3.44|P-value:1.98E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.70|P-value:6.15E-7 ID:SGTC_2815|Compound:7968870|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.18|P-value:5.22E-4 ID:SGTC_3021|Compound:9087658|FD-Score:5.12|P-value:6.36E-8 ID:SGTC_3029|Compound:9088683|FD-Score:5.46|P-value:9.04E-9 ID:SGTC_3078|Compound:9116413|FD-Score:3.66|P-value:7.95E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.42|P-value:2.09E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.01|P-value:9.57E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_3197|Compound:9113331|FD-Score:4.40|P-value:2.84E-6 ID:SGTC_3198|Compound:9112019|FD-Score:-3.02|P-value:8.85E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.41|P-value:2.20E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.69|P-value:6.66E-7

Top fitness defect scores for YHR189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_722 3534-0461 8.85 190.0 µM 3.27E-20 PDR1 2 4.38E-19
2 SGTC_3029 9088683 5.46 49.5 µM 9.04E-9 8 2.42E-8
3 SGTC_1751 st044839 5.24 27.2 µM 3.28E-8 Golgi 4 8.11E-8
4 SGTC_3021 9087658 5.12 49.5 µM 6.36E-8 2 1.51E-7
5 SGTC_480 am 92016 5.09 50.0 µM 7.67E-8 2 1.80E-7
6 SGTC_2809 7964133 4.70 13.0 µM 6.15E-7 60S ribosome export 19 1.28E-6
7 SGTC_3252 9135871 4.69 49.5 µM 6.66E-7 4 1.38E-6
8 SGTC_131 0141-0277 4.61 33.9 µM 9.73E-7 24 1.97E-6
9 SGTC_2068 5226020 4.45 147.0 µM 2.20E-6 20 4.24E-6
10 SGTC_3197 9113331 4.40 49.5 µM 2.84E-6 25 5.38E-6
11 SGTC_784 4579-0127 4.26 173.0 µM 5.56E-6 14 1.01E-5
12 SGTC_1749 st037932 4.17 54.2 µM 8.40E-6 25 1.49E-5
13 SGTC_1487 3970-0795 4.08 2.8 µM 1.27E-5 DNA intercalators 7 2.21E-5
14 SGTC_53 0973-0023 4.01 40.0 µM 1.75E-5 RNA processing & uracil transport 13 2.99E-5
15 SGTC_2422 chlorphenesin carbamate 3.97 384.2 µM 2.11E-5 25 3.56E-5
16 SGTC_679 0422-0091 3.96 41.4 µM 2.24E-5 Golgi 28 3.77E-5
17 SGTC_3180 9109287 3.95 49.5 µM 2.38E-5 12 3.98E-5
18 SGTC_1246 0422-0085 3.93 105.0 µM 2.55E-5 30 4.25E-5
19 SGTC_2815 7968870 3.83 71.4 µM 4.00E-5 26 6.50E-5
20 SGTC_3078 9116413 3.66 49.5 µM 7.95E-5 unfolded protein response 46 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.76E-10 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.094 5.53E-8 YBL096C_d YBL096C_d hom Non-essential protein of unknown function
0.091 1.41E-7 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.080 3.31E-6 YOR011W AUS1 hom Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
0.080 3.86E-6 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.073 2.17E-5 YGL023C PIB2 hom Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
0.071 3.74E-5 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.070 4.81E-5 YGR269W_d YGR269W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
0.069 6.04E-5 YOR337W TEA1 hom Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
0.066 1.27E-4 YKR044W UIP5 hom Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
0.065 1.60E-4 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.064 1.91E-4 YIR037W HYR1 hom Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
0.063 2.49E-4 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.062 3.61E-4 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.060 5.28E-4 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.