YHR190W / ERG9

Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR190W / ERG9

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-2.96|P-value:8.65E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.82|P-value:2.83E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.60|P-value:7.41E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:2.94|P-value:9.73E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.26|P-value:2.94E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.14|P-value:4.66E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:6.21|P-value:2.84E-11 ID:SGTC_489|Compound:paxilline|FD-Score:-3.29|P-value:2.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.12|P-value:3.17E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:3.66|P-value:5.52E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.38|P-value:1.84E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.14|P-value:4.59E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.03|P-value:6.70E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.17|P-value:3.93E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.51|P-value:1.04E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.67|P-value:5.38E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.11|P-value:5.25E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.27|P-value:2.81E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.01|P-value:7.42E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.23|P-value:3.24E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.34|P-value:2.14E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.18|P-value:3.91E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.09|P-value:5.48E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.35|P-value:2.23E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.22|P-value:3.36E-4 ID:SGTC_1758|Compound:st042942|FD-Score:4.47|P-value:1.22E-6 ID:SGTC_1843|Compound:st055809|FD-Score:3.59|P-value:7.58E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.80|P-value:3.06E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.97|P-value:1.39E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.10|P-value:5.40E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:2.95|P-value:9.27E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-5.65|P-value:1.17E-9 ID:SGTC_2016|Compound:5121758|FD-Score:6.17|P-value:3.64E-11 ID:SGTC_2248|Compound:tofa|FD-Score:3.09|P-value:5.65E-4 ID:SGTC_2307|Compound:7538926|FD-Score:6.77|P-value:4.39E-13 ID:SGTC_2308|Compound:7584454|FD-Score:6.21|P-value:2.79E-11 ID:SGTC_2312|Compound:7706453|FD-Score:3.70|P-value:4.65E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.27|P-value:2.82E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.41|P-value:1.54E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.60|P-value:5.81E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.28|P-value:2.65E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.29|P-value:2.50E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.10|P-value:5.42E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.55|P-value:2.34E-9 ID:SGTC_2811|Compound:7967822|FD-Score:4.91|P-value:1.13E-7 ID:SGTC_2815|Compound:7968870|FD-Score:13.30|P-value:3.79E-45 ID:SGTC_2974|Compound:9094440|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.23|P-value:3.96E-6 ID:SGTC_2997|Compound:9067075|FD-Score:6.25|P-value:2.05E-11 ID:SGTC_3131|Compound:9127911|FD-Score:-3.34|P-value:2.03E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.50|P-value:1.05E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:-2.96|P-value:8.65E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.82|P-value:2.83E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.60|P-value:7.41E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:2.94|P-value:9.73E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.26|P-value:2.94E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.14|P-value:4.66E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:6.21|P-value:2.84E-11 ID:SGTC_489|Compound:paxilline|FD-Score:-3.29|P-value:2.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.12|P-value:3.17E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:3.66|P-value:5.52E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.38|P-value:1.84E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.14|P-value:4.59E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.03|P-value:6.70E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.17|P-value:3.93E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.51|P-value:1.04E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.67|P-value:5.38E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.11|P-value:5.25E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.27|P-value:2.81E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.01|P-value:7.42E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.23|P-value:3.24E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.34|P-value:2.14E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.18|P-value:3.91E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.09|P-value:5.48E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.35|P-value:2.23E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.22|P-value:3.36E-4 ID:SGTC_1758|Compound:st042942|FD-Score:4.47|P-value:1.22E-6 ID:SGTC_1843|Compound:st055809|FD-Score:3.59|P-value:7.58E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.80|P-value:3.06E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.97|P-value:1.39E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.10|P-value:5.40E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:2.95|P-value:9.27E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-5.65|P-value:1.17E-9 ID:SGTC_2016|Compound:5121758|FD-Score:6.17|P-value:3.64E-11 ID:SGTC_2248|Compound:tofa|FD-Score:3.09|P-value:5.65E-4 ID:SGTC_2307|Compound:7538926|FD-Score:6.77|P-value:4.39E-13 ID:SGTC_2308|Compound:7584454|FD-Score:6.21|P-value:2.79E-11 ID:SGTC_2312|Compound:7706453|FD-Score:3.70|P-value:4.65E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.27|P-value:2.82E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.41|P-value:1.54E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.60|P-value:5.81E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.28|P-value:2.65E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.29|P-value:2.50E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.10|P-value:5.42E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.55|P-value:2.34E-9 ID:SGTC_2811|Compound:7967822|FD-Score:4.91|P-value:1.13E-7 ID:SGTC_2815|Compound:7968870|FD-Score:13.30|P-value:3.79E-45 ID:SGTC_2974|Compound:9094440|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.23|P-value:3.96E-6 ID:SGTC_2997|Compound:9067075|FD-Score:6.25|P-value:2.05E-11 ID:SGTC_3131|Compound:9127911|FD-Score:-3.34|P-value:2.03E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.50|P-value:1.05E-4

Top fitness defect scores for YHR190W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2815 7968870 13.30 71.4 µM 3.79E-45 1 1.06E-40 7.51
2 SGTC_2307 7538926 6.77 6.3 µM 4.39E-13 5 6.37E-12 0.51
3 SGTC_2997 9067075 6.25 71.4 µM 2.05E-11 unfolded protein response 8 2.02E-10 0.74
4 SGTC_2308 7584454 6.21 197.6 µM 2.79E-11 2 2.66E-10 0.37
5 SGTC_332 4112-0506 6.21 40.9 µM 2.84E-11 9 2.70E-10 0.21
6 SGTC_2016 5121758 6.17 140.0 µM 3.64E-11 redox potentiating 4 3.37E-10 0.22
7 SGTC_2807 7945238 5.55 52.0 µM 2.34E-9 1 1.43E-8 1.15
8 SGTC_513 4245-1575 5.12 41.7 µM 3.17E-8 unfolded protein response 17 1.49E-7 0.24
9 SGTC_2811 7967822 4.91 32.5 µM 1.13E-7 1 4.67E-7 0.50
10 SGTC_1758 st042942 4.47 75.2 µM 1.22E-6 1 4.00E-6 0.35
11 SGTC_1467 k284-1082 4.35 293.0 µM 2.23E-6 2 6.85E-6 0.58
12 SGTC_2982 9019404 4.23 26.0 µM 3.96E-6 4 1.15E-5 0.32
13 SGTC_1923 st058458 3.97 19.1 µM 1.39E-5 12 3.58E-5 0.25
14 SGTC_101 0490-5701 3.82 117.5 µM 2.83E-5 5 6.78E-5 0.05
15 SGTC_1868 st057644 3.80 42.7 µM 3.06E-5 7 7.29E-5 0.01
16 SGTC_2312 7706453 3.70 155.7 µM 4.65E-5 15 1.06E-4 0.08
17 SGTC_1044 1222-0021 3.67 1.8 µM 5.38E-5 heme biosynthesis & mitochondrial translocase 36 1.21E-4 0.00
18 SGTC_524 r073-0010 3.66 27.8 µM 5.52E-5 18 1.24E-4 0.15
19 SGTC_151 3013-0144 3.60 2.3 µM 7.41E-5 iron homeostasis 16 1.62E-4 0.17
20 SGTC_1843 st055809 3.59 45.5 µM 7.58E-5 10 1.65E-4 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.32E-18 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
0.136 3.16E-15 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.114 4.10E-11 YDR380W ARO10 hom Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
0.109 2.56E-10 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.106 6.29E-10 YPL058C PDR12 hom Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
0.102 3.53E-9 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.102 3.65E-9 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.65E-9 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.096 2.16E-8 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
0.096 2.23E-8 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.095 4.12E-8 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.094 4.45E-8 YPL204W HRR25 het Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
0.085 7.27E-7 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.085 9.39E-7 YER142C MAG1 hom 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
0.084 1.05E-6 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans