YHR192W / LNP1

Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR192W / LNP1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR192W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1091 telmisartan 5.78 47.6 µM 1.25E-7 1 3.76E-9
2 SGTC_341 1486-1430 5.24 230.0 µM 1.54E-6 9 8.21E-8
3 SGTC_16 erodoxin 5.11 22.8 µM 2.69E-6 unfolded protein response 35 1.62E-7
4 SGTC_2359 9039622 4.59 200.0 µM 2.22E-5 endomembrane recycling 11 2.18E-6
5 SGTC_2266 7929956 4.49 200.0 µM 3.28E-5 18 3.50E-6
6 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 4.26 85.4 µM 7.81E-5 16 1.02E-5
7 SGTC_2569 tetrandrine 3.66 100.0 µM 6.07E-4 28 1.26E-4
8 SGTC_2275 7947463 3.64 200.0 µM 6.40E-4 iron homeostasis 46 1.35E-4
9 SGTC_2675 theaflavin digallate 3.61 100.0 µM 7.00E-4 iron homeostasis 40 1.51E-4
10 SGTC_1830 st055982 3.54 50.3 µM 8.75E-4 33 1.98E-4
11 SGTC_1952 st077036 3.52 64.1 µM 9.24E-4 48 2.12E-4
12 SGTC_3033 9090887 3.51 49.5 µM 9.53E-4 fatty acid desaturase (OLE1) 42 2.20E-4
13 SGTC_15 0266-0086 3.48 27.1 µM 0.00106 endomembrane recycling 86 2.51E-4
14 SGTC_481 bay k-8644 3.44 50.0 µM 0.00119 37 2.90E-4
15 SGTC_2272 7805186 3.41 180.0 µM 0.00132 cell wall signaling 31 3.29E-4
16 SGTC_1872 amphotericin b 3.38 148.0 nM 0.00142 RNA pol III & RNase P/MRP 45 3.59E-4
17 SGTC_1712 st032288 3.32 53.4 µM 0.00171 calcium & mitochondrial duress 233 4.51E-4
18 SGTC_2405 ticlatone 3.30 3.5 µM 0.00180 104 4.81E-4
19 SGTC_1896 st058441 3.29 89.0 µM 0.00187 32 5.04E-4
20 SGTC_2625 euphol 3.23 100.0 µM 0.00218 64 6.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.19E-17 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.130 3.90E-14 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.128 1.19E-13 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.120 3.21E-12 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.119 4.11E-12 YHL020C OPI1 hom Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
0.112 8.96E-11 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.096 2.26E-8 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.088 2.89E-7 YER044C ERG28 hom Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
0.088 3.22E-7 YMR161W HLJ1 hom Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
0.087 4.52E-7 YDR389W SAC7 hom GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.085 7.58E-7 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.083 1.48E-6 YCL052C PBN1 het Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
0.080 3.54E-6 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.079 4.28E-6 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.078 6.46E-6 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data