YHR196W / UTP9

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR196W / UTP9

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.43|P-value:6.70E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.40|P-value:4.99E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.43|P-value:6.65E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.78|P-value:1.99E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.07|P-value:4.32E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.30|P-value:7.15E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.11|P-value:7.55E-7 ID:SGTC_557|Compound:1315-0110|FD-Score:3.64|P-value:3.27E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.38|P-value:1.95E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.32|P-value:9.57E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:9.42|P-value:2.68E-19 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.23|P-value:8.75E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.76|P-value:1.40E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.45|P-value:4.21E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.45|P-value:6.16E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.69|P-value:2.70E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.71|P-value:1.68E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.71|P-value:2.53E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.31|P-value:1.64E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.61|P-value:4.57E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.53|P-value:6.34E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.21|P-value:5.02E-12 ID:SGTC_1605|Compound:st000082|FD-Score:-3.92|P-value:7.71E-5 ID:SGTC_1619|Compound:st003326|FD-Score:-5.36|P-value:1.29E-7 ID:SGTC_1673|Compound:st016611|FD-Score:4.52|P-value:1.08E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.88|P-value:1.37E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.97|P-value:1.51E-6 ID:SGTC_1723|Compound:st034307|FD-Score:-4.41|P-value:1.07E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.34|P-value:6.21E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.61|P-value:3.67E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.41|P-value:7.14E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.66|P-value:2.74E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.36|P-value:8.36E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.98|P-value:9.45E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.52|P-value:3.38E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.66|P-value:2.04E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.72|P-value:1.64E-4 ID:SGTC_1961|Compound:st076550|FD-Score:6.08|P-value:4.94E-9 ID:SGTC_2003|Compound:4023581|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.39|P-value:1.12E-7 ID:SGTC_2067|Compound:5224629|FD-Score:-4.35|P-value:1.40E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.50|P-value:5.32E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.17|P-value:2.89E-5 ID:SGTC_2288|Compound:7946289|FD-Score:5.92|P-value:1.24E-8 ID:SGTC_2290|Compound:7904846|FD-Score:8.20|P-value:4.56E-15 ID:SGTC_2291|Compound:7917025|FD-Score:-7.63|P-value:1.28E-13 ID:SGTC_2322|Compound:7413319|FD-Score:4.56|P-value:9.28E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.27|P-value:1.93E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-6.61|P-value:1.17E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.38|P-value:7.96E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.91|P-value:8.03E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.55|P-value:9.73E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.33|P-value:6.36E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-4.00|P-value:5.63E-5 ID:SGTC_2829|Compound:7992743|FD-Score:4.10|P-value:6.10E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.64|P-value:3.31E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.22|P-value:9.26E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.84|P-value:1.04E-4 ID:SGTC_3199|Compound:9111318|FD-Score:5.40|P-value:1.91E-7 ID:SGTC_15|Compound:0266-0086|FD-Score:3.43|P-value:6.70E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.40|P-value:4.99E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.43|P-value:6.65E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.78|P-value:1.99E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.07|P-value:4.32E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.30|P-value:7.15E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.11|P-value:7.55E-7 ID:SGTC_557|Compound:1315-0110|FD-Score:3.64|P-value:3.27E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.38|P-value:1.95E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.32|P-value:9.57E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:9.42|P-value:2.68E-19 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.23|P-value:8.75E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.76|P-value:1.40E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.45|P-value:4.21E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.45|P-value:6.16E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.69|P-value:2.70E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.71|P-value:1.68E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.71|P-value:2.53E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.31|P-value:1.64E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.61|P-value:4.57E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.53|P-value:6.34E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.21|P-value:5.02E-12 ID:SGTC_1605|Compound:st000082|FD-Score:-3.92|P-value:7.71E-5 ID:SGTC_1619|Compound:st003326|FD-Score:-5.36|P-value:1.29E-7 ID:SGTC_1673|Compound:st016611|FD-Score:4.52|P-value:1.08E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.88|P-value:1.37E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.97|P-value:1.51E-6 ID:SGTC_1723|Compound:st034307|FD-Score:-4.41|P-value:1.07E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.34|P-value:6.21E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.61|P-value:3.67E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.41|P-value:7.14E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.66|P-value:2.74E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.36|P-value:8.36E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.98|P-value:9.45E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.52|P-value:3.38E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.66|P-value:2.04E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.72|P-value:1.64E-4 ID:SGTC_1961|Compound:st076550|FD-Score:6.08|P-value:4.94E-9 ID:SGTC_2003|Compound:4023581|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.39|P-value:1.12E-7 ID:SGTC_2067|Compound:5224629|FD-Score:-4.35|P-value:1.40E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.50|P-value:5.32E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.17|P-value:2.89E-5 ID:SGTC_2288|Compound:7946289|FD-Score:5.92|P-value:1.24E-8 ID:SGTC_2290|Compound:7904846|FD-Score:8.20|P-value:4.56E-15 ID:SGTC_2291|Compound:7917025|FD-Score:-7.63|P-value:1.28E-13 ID:SGTC_2322|Compound:7413319|FD-Score:4.56|P-value:9.28E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.27|P-value:1.93E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-6.61|P-value:1.17E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.38|P-value:7.96E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.91|P-value:8.03E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.55|P-value:9.73E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.33|P-value:6.36E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-4.00|P-value:5.63E-5 ID:SGTC_2829|Compound:7992743|FD-Score:4.10|P-value:6.10E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.64|P-value:3.31E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.22|P-value:9.26E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.84|P-value:1.04E-4 ID:SGTC_3199|Compound:9111318|FD-Score:5.40|P-value:1.91E-7

Top fitness defect scores for YHR196W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_900 1112-0045 9.42 141.0 µM 2.68E-19 NEO1 2 2.31E-21 4.68
2 SGTC_2290 7904846 8.20 200.0 µM 4.56E-15 2 1.15E-16 0.38
3 SGTC_1597 7-benzyloxygramine 7.21 47.5 µM 5.02E-12 calcium & mitochondrial duress 25 2.77E-13 0.02
4 SGTC_1961 st076550 6.08 68.7 µM 4.94E-9 2 5.89E-10 0.98
5 SGTC_2288 7946289 5.92 167.3 µM 1.24E-8 1 1.64E-9 0.83
6 SGTC_3199 9111318 5.40 49.5 µM 1.91E-7 4 3.43E-8 0.18
7 SGTC_445 e6 berbamine 5.11 66.0 µM 7.55E-7 NEO1-PIK1 18 1.59E-7 0.25
8 SGTC_1712 st032288 4.97 53.4 µM 1.51E-6 calcium & mitochondrial duress 25 3.43E-7 0.16
9 SGTC_2322 7413319 4.56 38.2 µM 9.28E-6 ERAD & cell cycle 17 2.59E-6 0.29
10 SGTC_2779 methotrexate 4.55 400.0 µM 9.73E-6 13 2.73E-6 0.07
11 SGTC_1673 st016611 4.52 27.3 µM 1.08E-5 4 3.06E-6 0.38
12 SGTC_562 3772-2733 4.38 112.0 µM 1.95E-5 ERG2 10 5.92E-6 0.35
13 SGTC_2829 7992743 4.10 58.4 µM 6.10E-5 4 2.11E-5 0.03
14 SGTC_1847 st056231 3.98 15.0 µM 9.45E-5 4 3.43E-5 0.39
15 SGTC_2003 4023581 3.94 200.0 µM 1.12E-4 cell wall signaling 8 4.14E-5 0.07
16 SGTC_1701 st028638 3.88 40.4 µM 1.37E-4 4 5.19E-5 0.06
17 SGTC_262 fenpropimorph 3.78 62.5 µM 1.99E-4 ergosterol depletion effects on membrane 17 7.86E-5 0.04
18 SGTC_1448 4255-0083 3.71 152.0 µM 2.53E-4 ERG2 4 1.03E-4 0.05
19 SGTC_273 hydroxyurea 3.70 18.1 mM 2.65E-4 heme biosynthesis & mitochondrial translocase 25 1.08E-4 0.03
20 SGTC_1308 1187-1617 3.69 41.4 µM 2.70E-4 fatty acid desaturase (OLE1) 13 1.10E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.44E-21 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.138 8.56E-16 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.128 9.61E-14 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.125 4.13E-13 YGR128C UTP8 het Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.122 1.19E-12 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.122 1.51E-12 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.119 5.14E-12 YKL145W RPT1 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
0.118 6.33E-12 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.117 8.62E-12 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.117 1.02E-11 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.116 1.41E-11 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.115 2.97E-11 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.114 3.88E-11 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.114 4.23E-11 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.113 5.00E-11 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion