HIPHOP chemogenomics database

YHR197W / RIX1

Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene

Zygosity: Heterozygous strain

fixedexpanded
Profile for YHR197W / RIX1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR197W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_696	1560-0013	7.39	611.0 µM	2.70E-12		2	7.26E-14	1.71
2	SGTC_2524	avocatin b	5.37	10.6 µM	2.83E-7		1	3.91E-8	2.44
3	SGTC_2145	5634607	5.30	200.0 µM	3.99E-7		1	5.79E-8	1.09
4	SGTC_2121	5257820	5.04	149.6 µM	1.34E-6		2	2.31E-7	0.47
5	SGTC_2118	5526350	4.91	200.0 µM	2.47E-6		2	4.64E-7	0.20
6	SGTC_1033	k072-0102	4.88	21.3 µM	2.72E-6	60S ribosome export	3	5.18E-7	0.42
7	SGTC_3257	9139206	4.69	33.0 µM	6.38E-6		3	1.37E-6	0.83
8	SGTC_3333	9141820	4.60	12.1 µM	9.44E-6		2	2.14E-6	0.58
9	SGTC_693	4161-2696	4.57	114.0 µM	1.05E-5		1	2.42E-6	0.30
10	SGTC_2630	antimycin a	4.56	100.0 µM	1.10E-5	mitochondrial processes	6	2.56E-6	0.17
11	SGTC_2997	9067075	4.56	71.4 µM	1.12E-5	unfolded protein response	16	2.59E-6	0.15
12	SGTC_3325	9138760	4.55	55.2 µM	1.16E-5	Golgi	2	2.71E-6	0.11
13	SGTC_2468	5987765	4.54	72.9 µM	1.20E-5		1	2.81E-6	0.43
14	SGTC_2432	5630864	4.37	12.2 µM	2.41E-5		3	6.23E-6	0.41
15	SGTC_2061	5245884	4.36	81.0 µM	2.49E-5	tubulin folding & SWR complex	4	6.48E-6	0.11
16	SGTC_1952	st077036	4.00	64.1 µM	9.88E-5		12	3.11E-5	0.02
17	SGTC_438	sphingosine	3.94	6.7 µM	1.23E-4		1	4.00E-5	0.35
18	SGTC_2464	5717415	3.87	7.7 µM	1.61E-4		2	5.43E-5	0.25
19	SGTC_596	1155-0152	3.86	116.0 µM	1.66E-4	TRP & mitochondrial translation	8	5.65E-5	0.09
20	SGTC_1890	3',4',7',8'-tetrahydroxyflavone	3.85	14.9 µM	1.71E-4		5	5.82E-5	0.08

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.141	1.76E-16	YBR193C	MED8	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.122	1.14E-12	YCR013C_d	YCR013C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.122	1.34E-12	YMR270C	RRN9	het	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.117	9.54E-12	YBL020W	RFT1	het	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.105	1.06E-9	YNL161W	CBK1	het	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.104	1.43E-9	YKL083W_d	YKL083W_d	het	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.101	4.63E-9	YDR498C	SEC20	het	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
0.098	1.10E-8	YAR008W	SEN34	het	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.098	1.36E-8	YNL151C	RPC31	het	RNA polymerase III subunit C31
0.096	2.60E-8	YML098W	TAF13	het	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.095	3.75E-8	YER126C	NSA2	het	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
0.094	4.82E-8	YDR294C	DPL1	hom	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.092	1.01E-7	YDR082W	STN1	het	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.092	1.03E-7	YDR373W	FRQ1	het	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
0.091	1.23E-7	YML046W	PRP39	het	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats