HIPHOP chemogenomics database
YHR198C / AIM18 
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YHR198C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.085 | 7.78E-7 | YDL108W | KIN28 | het | Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters |
| 0.084 | 1.07E-6 | YKL099C | UTP11 | het | Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit |
| 0.079 | 4.44E-6 | YER090W | TRP2 | hom | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
| 0.078 | 6.37E-6 | YJL101C | GSH1 | hom | Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress |
| 0.078 | 6.59E-6 | YPL227C | ALG5 | hom | UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum |
| 0.074 | 1.59E-5 | YGR221C | TOS2 | hom | Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p |
| 0.074 | 1.74E-5 | YKR047W_d | YKR047W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 |
| 0.073 | 2.41E-5 | YDR284C | DPP1 | hom | Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism |
| 0.072 | 2.87E-5 | YHR021W-A_p | ECM12_p | hom | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity |
| 0.069 | 6.10E-5 | YOR009W | TIR4 | hom | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock |
| 0.069 | 7.30E-5 | YDR002W | YRB1 | het | Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 |
| 0.068 | 7.73E-5 | YMR292W | GOT1 | hom | Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition |
| 0.066 | 1.24E-4 | YGL233W | SEC15 | het | Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase |
| 0.065 | 1.67E-4 | YLR226W | BUR2 | hom | Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II |
| 0.065 | 1.81E-4 | YPR157W_p | TDA6_p | hom | Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele |