YHR198C / AIM18

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR198C / AIM18

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.45|P-value:3.63E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.23|P-value:7.25E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:7.41|P-value:1.50E-13 ID:SGTC_168|Compound:3970-0862|FD-Score:4.98|P-value:4.66E-7 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:5.77|P-value:6.58E-9 ID:SGTC_518|Compound:1021-0119|FD-Score:4.11|P-value:2.54E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:4.80|P-value:1.15E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:4.04|P-value:3.39E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.23|P-value:1.51E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.26|P-value:1.36E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.18|P-value:8.61E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.45|P-value:3.36E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.63|P-value:3.38E-11 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.17|P-value:2.02E-5 ID:SGTC_1531|Compound:st059297|FD-Score:4.66|P-value:2.25E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.30|P-value:1.15E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.51|P-value:4.44E-6 ID:SGTC_1620|Compound:st003704|FD-Score:3.94|P-value:5.07E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.84|P-value:7.64E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.48|P-value:3.32E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.95|P-value:4.92E-5 ID:SGTC_1804|Compound:st050076|FD-Score:4.32|P-value:1.03E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.91|P-value:5.88E-5 ID:SGTC_1814|Compound:st052110|FD-Score:4.54|P-value:3.76E-6 ID:SGTC_1898|Compound:st060199|FD-Score:4.54|P-value:3.79E-6 ID:SGTC_1968|Compound:st069590|FD-Score:4.19|P-value:1.84E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.21|P-value:7.68E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.95|P-value:5.03E-5 ID:SGTC_2296|Compound:7971656|FD-Score:6.86|P-value:7.33E-12 ID:SGTC_2307|Compound:7538926|FD-Score:3.28|P-value:6.12E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.23|P-value:1.55E-5 ID:SGTC_2339|Compound:9000433|FD-Score:6.98|P-value:3.10E-12 ID:SGTC_2345|Compound:9052315|FD-Score:4.44|P-value:6.20E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.80|P-value:9.00E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.31|P-value:1.09E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.17|P-value:8.86E-4 ID:SGTC_2472|Compound:5377652|FD-Score:6.28|P-value:3.05E-10 ID:SGTC_2556|Compound:citropten|FD-Score:3.53|P-value:2.48E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.40|P-value:7.40E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:5.45|P-value:4.04E-8 ID:SGTC_3089|Compound:9117425|FD-Score:3.71|P-value:1.29E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.55|P-value:2.28E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.27|P-value:6.27E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.32|P-value:5.27E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_3213|Compound:9129884|FD-Score:6.11|P-value:8.66E-10 ID:SGTC_3227|Compound:9130768|FD-Score:4.61|P-value:2.84E-6 ID:SGTC_3255|Compound:9139072|FD-Score:-3.38|P-value:4.71E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.45|P-value:3.63E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.23|P-value:7.25E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:7.41|P-value:1.50E-13 ID:SGTC_168|Compound:3970-0862|FD-Score:4.98|P-value:4.66E-7 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:5.77|P-value:6.58E-9 ID:SGTC_518|Compound:1021-0119|FD-Score:4.11|P-value:2.54E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:4.80|P-value:1.15E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:4.04|P-value:3.39E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.23|P-value:1.51E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.26|P-value:1.36E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.18|P-value:8.61E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.45|P-value:3.36E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.63|P-value:3.38E-11 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.17|P-value:2.02E-5 ID:SGTC_1531|Compound:st059297|FD-Score:4.66|P-value:2.25E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.30|P-value:1.15E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.51|P-value:4.44E-6 ID:SGTC_1620|Compound:st003704|FD-Score:3.94|P-value:5.07E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.84|P-value:7.64E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-3.48|P-value:3.32E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.95|P-value:4.92E-5 ID:SGTC_1804|Compound:st050076|FD-Score:4.32|P-value:1.03E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.91|P-value:5.88E-5 ID:SGTC_1814|Compound:st052110|FD-Score:4.54|P-value:3.76E-6 ID:SGTC_1898|Compound:st060199|FD-Score:4.54|P-value:3.79E-6 ID:SGTC_1968|Compound:st069590|FD-Score:4.19|P-value:1.84E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.21|P-value:7.68E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.95|P-value:5.03E-5 ID:SGTC_2296|Compound:7971656|FD-Score:6.86|P-value:7.33E-12 ID:SGTC_2307|Compound:7538926|FD-Score:3.28|P-value:6.12E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.23|P-value:1.55E-5 ID:SGTC_2339|Compound:9000433|FD-Score:6.98|P-value:3.10E-12 ID:SGTC_2345|Compound:9052315|FD-Score:4.44|P-value:6.20E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.80|P-value:9.00E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.31|P-value:1.09E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.17|P-value:8.86E-4 ID:SGTC_2472|Compound:5377652|FD-Score:6.28|P-value:3.05E-10 ID:SGTC_2556|Compound:citropten|FD-Score:3.53|P-value:2.48E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.40|P-value:7.40E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:5.45|P-value:4.04E-8 ID:SGTC_3089|Compound:9117425|FD-Score:3.71|P-value:1.29E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.55|P-value:2.28E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.27|P-value:6.27E-4 ID:SGTC_3111|Compound:9122088|FD-Score:3.32|P-value:5.27E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_3213|Compound:9129884|FD-Score:6.11|P-value:8.66E-10 ID:SGTC_3227|Compound:9130768|FD-Score:4.61|P-value:2.84E-6 ID:SGTC_3255|Compound:9139072|FD-Score:-3.38|P-value:4.71E-4

Top fitness defect scores for YHR198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_139 0099-0334 7.41 718.6 µM 1.50E-13 2 6.29E-14
2 SGTC_2339 9000433 6.98 200.0 µM 3.10E-12 1 1.44E-12
3 SGTC_2296 7971656 6.86 126.5 µM 7.33E-12 6 3.50E-12
4 SGTC_1072 oxiconazole 6.63 14.9 nM 3.38E-11 ergosterol depletion effects on membrane 18 1.70E-11
5 SGTC_2472 5377652 6.28 49.4 µM 3.05E-10 TRP & mitochondrial translation 21 1.64E-10
6 SGTC_3213 9129884 6.11 49.5 µM 8.66E-10 4 4.83E-10
7 SGTC_506 n9-isopropylolomoucine 5.77 153.0 µM 6.58E-9 1 3.92E-9
8 SGTC_2726 cimetidine 5.45 79.3 µM 4.04E-8 3 2.56E-8
9 SGTC_168 3970-0862 4.98 530.5 µM 4.66E-7 71 3.19E-7
10 SGTC_526 4469-0568 4.80 170.0 µM 1.15E-6 azole & statin 23 8.11E-7
11 SGTC_1531 st059297 4.66 52.4 µM 2.25E-6 5 1.62E-6
12 SGTC_3227 9130768 4.61 49.5 µM 2.84E-6 3 2.06E-6
13 SGTC_1814 st052110 4.54 31.5 µM 3.76E-6 RNA processing & uracil transport 8 2.75E-6
14 SGTC_1898 st060199 4.54 18.6 µM 3.79E-6 5 2.77E-6
15 SGTC_1613 st002381 4.51 52.1 µM 4.44E-6 13 3.26E-6
16 SGTC_2345 9052315 4.44 157.4 µM 6.20E-6 14 4.60E-6
17 SGTC_2630 antimycin a 4.40 100.0 µM 7.40E-6 mitochondrial processes 25 5.52E-6
18 SGTC_1804 st050076 4.32 49.1 µM 1.03E-5 8 7.74E-6
19 SGTC_2454 5-benzylidenerhodanine 4.31 10.4 µM 1.09E-5 TRP & mitochondrial translation 26 8.26E-6
20 SGTC_1601 4'-hydroxyflavanone 4.30 55.5 µM 1.15E-5 RPP1 & pyrimidine depletion 24 8.69E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.085 7.78E-7 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.084 1.07E-6 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.079 4.44E-6 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.078 6.37E-6 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.078 6.59E-6 YPL227C ALG5 hom UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
0.074 1.59E-5 YGR221C TOS2 hom Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
0.074 1.74E-5 YKR047W_d YKR047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.073 2.41E-5 YDR284C DPP1 hom Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
0.072 2.87E-5 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.069 6.10E-5 YOR009W TIR4 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
0.069 7.30E-5 YDR002W YRB1 het Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
0.068 7.73E-5 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.066 1.24E-4 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.065 1.67E-4 YLR226W BUR2 hom Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
0.065 1.81E-4 YPR157W_p TDA6_p hom Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele