YHR199C / AIM46

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR199C / AIM46

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:3.84|P-value:3.23E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.25|P-value:7.44E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:8.07|P-value:9.44E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.74|P-value:1.23E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-5.23|P-value:2.17E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:4.76|P-value:9.94E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.56|P-value:8.18E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.43|P-value:3.61E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.61|P-value:7.14E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:6.18|P-value:1.11E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:6.47|P-value:2.29E-9 ID:SGTC_850|Compound:0388-0143|FD-Score:5.22|P-value:1.33E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.70|P-value:1.29E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.64|P-value:1.81E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.53|P-value:9.05E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.71|P-value:5.12E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.80|P-value:3.79E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.60|P-value:7.32E-4 ID:SGTC_1618|Compound:st003135|FD-Score:8.66|P-value:1.37E-15 ID:SGTC_1623|Compound:st003709|FD-Score:5.28|P-value:1.00E-6 ID:SGTC_1704|Compound:st028805|FD-Score:4.93|P-value:4.80E-6 ID:SGTC_1792|Compound:st045773|FD-Score:3.72|P-value:4.98E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.86|P-value:3.08E-4 ID:SGTC_1947|Compound:st076332|FD-Score:5.30|P-value:9.06E-7 ID:SGTC_1961|Compound:st076550|FD-Score:3.81|P-value:3.62E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.30|P-value:6.12E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.56|P-value:8.17E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.39|P-value:4.45E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.53|P-value:9.05E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.04|P-value:1.65E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.57|P-value:8.01E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.86|P-value:3.10E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.41|P-value:4.08E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.71|P-value:5.15E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.73|P-value:4.80E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-4.20|P-value:2.13E-5 ID:SGTC_3105|Compound:9121040|FD-Score:-3.22|P-value:7.21E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.93|P-value:2.42E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.84|P-value:3.23E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.25|P-value:7.44E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:8.07|P-value:9.44E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.74|P-value:1.23E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-5.23|P-value:2.17E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:4.76|P-value:9.94E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.56|P-value:8.18E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.43|P-value:3.61E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.61|P-value:7.14E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:6.18|P-value:1.11E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:6.47|P-value:2.29E-9 ID:SGTC_850|Compound:0388-0143|FD-Score:5.22|P-value:1.33E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.70|P-value:1.29E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.64|P-value:1.81E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.53|P-value:9.05E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.71|P-value:5.12E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.80|P-value:3.79E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.60|P-value:7.32E-4 ID:SGTC_1618|Compound:st003135|FD-Score:8.66|P-value:1.37E-15 ID:SGTC_1623|Compound:st003709|FD-Score:5.28|P-value:1.00E-6 ID:SGTC_1704|Compound:st028805|FD-Score:4.93|P-value:4.80E-6 ID:SGTC_1792|Compound:st045773|FD-Score:3.72|P-value:4.98E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.86|P-value:3.08E-4 ID:SGTC_1947|Compound:st076332|FD-Score:5.30|P-value:9.06E-7 ID:SGTC_1961|Compound:st076550|FD-Score:3.81|P-value:3.62E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.30|P-value:6.12E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.56|P-value:8.17E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.39|P-value:4.45E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.53|P-value:9.05E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.04|P-value:1.65E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.57|P-value:8.01E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.86|P-value:3.10E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.41|P-value:4.08E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.71|P-value:5.15E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.73|P-value:4.80E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-4.20|P-value:2.13E-5 ID:SGTC_3105|Compound:9121040|FD-Score:-3.22|P-value:7.21E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.93|P-value:2.42E-4

Top fitness defect scores for YHR199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1618 st003135 8.66 44.5 µM 1.37E-15 1 2.44E-18
2 SGTC_175 3793-3120 8.07 23.7 µM 9.44E-14 1 3.48E-16
3 SGTC_823 0417-1665 6.47 178.0 µM 2.29E-9 14 4.90E-11
4 SGTC_820 1582-0060 6.18 59.9 µM 1.11E-8 7 3.16E-10
5 SGTC_1308 1187-1617 5.64 41.4 µM 1.81E-7 fatty acid desaturase (OLE1) 13 8.48E-9
6 SGTC_1947 st076332 5.30 61.6 µM 9.06E-7 2 5.68E-8
7 SGTC_1623 st003709 5.28 20.3 µM 1.00E-6 calcium & mitochondrial duress 23 6.41E-8
8 SGTC_850 0388-0143 5.22 75.9 µM 1.33E-6 3 8.96E-8
9 SGTC_1704 st028805 4.93 70.8 µM 4.80E-6 4 4.08E-7
10 SGTC_301 4119-0100 4.76 24.5 µM 9.94E-6 NEO1 58 9.67E-7
11 SGTC_1258 0671-0043 4.70 57.1 µM 1.29E-5 9 1.31E-6
12 SGTC_2765 myclobutanil 4.41 7.7 µM 4.08E-5 azole & statin 36 5.16E-6
13 SGTC_2513 baicalein 4.39 25.6 µM 4.45E-5 calcium & mitochondrial duress 19 5.72E-6
14 SGTC_2106 5357045 4.30 167.3 µM 6.12E-5 11 8.35E-6
15 SGTC_174 3553-0389 4.25 74.3 µM 7.44E-5 16 1.05E-5
16 SGTC_2627 acetyl isogambogic acid 4.04 100.0 µM 1.65E-4 TSC3-RPN4 38 2.71E-5
17 SGTC_3130 9127414 3.93 49.5 µM 2.42E-4 21 4.29E-5
18 SGTC_1922 5578187 3.86 25.0 µM 3.08E-4 TRP & mitochondrial translation 36 5.71E-5
19 SGTC_2755 lomerizine 3.86 42.7 µM 3.10E-4 27 5.76E-5
20 SGTC_76 0433-0009 3.84 400.3 µM 3.23E-4 15 6.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 5.91E-7 YER065C ICL1 hom Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
0.084 1.10E-6 YDR022C ATG31 hom Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
0.081 2.98E-6 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.079 4.98E-6 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.077 7.64E-6 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.073 2.12E-5 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.073 2.14E-5 YFR038W IRC5 hom Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
0.070 4.73E-5 YER126C NSA2 het Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
0.070 4.78E-5 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.069 5.89E-5 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.067 1.14E-4 YHL024W RIM4 hom Putative RNA-binding protein required for the expression of early and middle sporulation genes
0.066 1.16E-4 YOR340C RPA43 het RNA polymerase I subunit A43
0.066 1.25E-4 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.066 1.34E-4 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.064 1.97E-4 YFL019C_d YFL019C_d hom Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene