YHR206W / SKN7

Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR206W / SKN7

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.32|P-value:8.38E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:12.00|P-value:3.40E-26 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.69|P-value:5.95E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.93|P-value:3.03E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-5.64|P-value:3.90E-7 ID:SGTC_84|Compound:0443-0269|FD-Score:4.16|P-value:1.45E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.81|P-value:4.42E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.89|P-value:2.80E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:3.86|P-value:3.83E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.67|P-value:6.96E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:4.05|P-value:2.08E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.75|P-value:5.41E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.00|P-value:2.25E-4 ID:SGTC_394|Compound:menadione|FD-Score:13.10|P-value:1.17E-30 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.00|P-value:2.45E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.63|P-value:7.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.34|P-value:7.61E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.04|P-value:2.13E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.54|P-value:5.09E-9 ID:SGTC_470|Compound:aa-861|FD-Score:5.09|P-value:4.48E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.94|P-value:7.54E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.48|P-value:4.71E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.75|P-value:4.98E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.26|P-value:1.00E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:7.24|P-value:1.33E-10 ID:SGTC_833|Compound:3852-0053|FD-Score:4.02|P-value:2.28E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.75|P-value:5.42E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.03|P-value:5.80E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.18|P-value:1.32E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:5.08|P-value:4.75E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.18|P-value:1.34E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-5.19|P-value:2.71E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.57|P-value:8.79E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.13|P-value:1.59E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-4.19|P-value:1.19E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.85|P-value:3.92E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.60|P-value:7.82E-4 ID:SGTC_1530|Compound:rhein|FD-Score:6.02|P-value:7.40E-8 ID:SGTC_1556|Compound:plumbagin|FD-Score:17.00|P-value:2.65E-50 ID:SGTC_1643|Compound:st009866|FD-Score:4.00|P-value:2.46E-4 ID:SGTC_1657|Compound:st012939|FD-Score:6.87|P-value:1.01E-9 ID:SGTC_1713|Compound:st033146|FD-Score:-4.08|P-value:1.71E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.37|P-value:5.41E-11 ID:SGTC_1826|Compound:st055655|FD-Score:4.26|P-value:1.01E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.94|P-value:1.07E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.87|P-value:3.69E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.62|P-value:7.93E-4 ID:SGTC_1931|Compound:st074438|FD-Score:5.47|P-value:9.14E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.68|P-value:6.66E-4 ID:SGTC_2004|Compound:4023728|FD-Score:5.80|P-value:2.06E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-5.11|P-value:3.79E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-4.61|P-value:2.68E-5 ID:SGTC_2024|Compound:5144227|FD-Score:4.75|P-value:1.73E-5 ID:SGTC_2043|Compound:5101342|FD-Score:6.73|P-value:2.06E-9 ID:SGTC_2052|Compound:5265182|FD-Score:4.72|P-value:1.89E-5 ID:SGTC_2058|Compound:5236698|FD-Score:5.03|P-value:5.62E-6 ID:SGTC_2068|Compound:5226020|FD-Score:5.35|P-value:1.51E-6 ID:SGTC_2077|Compound:5212015|FD-Score:4.00|P-value:2.43E-4 ID:SGTC_2088|Compound:5278280|FD-Score:12.20|P-value:6.81E-27 ID:SGTC_2111|Compound:5486399|FD-Score:4.68|P-value:2.23E-5 ID:SGTC_2133|Compound:5320837|FD-Score:5.40|P-value:1.22E-6 ID:SGTC_2198|Compound:6589944|FD-Score:8.26|P-value:2.66E-13 ID:SGTC_2205|Compound:7238770|FD-Score:5.73|P-value:2.81E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.99|P-value:1.48E-12 ID:SGTC_2259|Compound:7964009|FD-Score:17.10|P-value:1.19E-50 ID:SGTC_2313|Compound:7726885|FD-Score:3.55|P-value:9.91E-4 ID:SGTC_2356|Compound:9061756|FD-Score:4.54|P-value:3.79E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.29|P-value:9.01E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.74|P-value:5.51E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.06|P-value:1.97E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.61|P-value:8.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.08|P-value:1.90E-4 ID:SGTC_2681|Compound:menadione|FD-Score:15.00|P-value:8.89E-40 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.16|P-value:1.43E-4 ID:SGTC_2781|Compound:5567276|FD-Score:6.43|P-value:9.84E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-5.58|P-value:4.97E-7 ID:SGTC_2937|Compound:9044753|FD-Score:3.69|P-value:6.44E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.00|P-value:2.42E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.99|P-value:2.32E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.63|P-value:7.79E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.80|P-value:4.64E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.56|P-value:8.86E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.53|P-value:9.90E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.32|P-value:8.38E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:12.00|P-value:3.40E-26 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.69|P-value:5.95E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.93|P-value:3.03E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-5.64|P-value:3.90E-7 ID:SGTC_84|Compound:0443-0269|FD-Score:4.16|P-value:1.45E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.81|P-value:4.42E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.89|P-value:2.80E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:3.86|P-value:3.83E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.67|P-value:6.96E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:4.05|P-value:2.08E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.75|P-value:5.41E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.00|P-value:2.25E-4 ID:SGTC_394|Compound:menadione|FD-Score:13.10|P-value:1.17E-30 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.00|P-value:2.45E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.63|P-value:7.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.34|P-value:7.61E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.04|P-value:2.13E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.54|P-value:5.09E-9 ID:SGTC_470|Compound:aa-861|FD-Score:5.09|P-value:4.48E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.94|P-value:7.54E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.48|P-value:4.71E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.75|P-value:4.98E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.26|P-value:1.00E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:7.24|P-value:1.33E-10 ID:SGTC_833|Compound:3852-0053|FD-Score:4.02|P-value:2.28E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.75|P-value:5.42E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:5.03|P-value:5.80E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.18|P-value:1.32E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:5.08|P-value:4.75E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.18|P-value:1.34E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-5.19|P-value:2.71E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.57|P-value:8.79E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.13|P-value:1.59E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-4.19|P-value:1.19E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.85|P-value:3.92E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.60|P-value:7.82E-4 ID:SGTC_1530|Compound:rhein|FD-Score:6.02|P-value:7.40E-8 ID:SGTC_1556|Compound:plumbagin|FD-Score:17.00|P-value:2.65E-50 ID:SGTC_1643|Compound:st009866|FD-Score:4.00|P-value:2.46E-4 ID:SGTC_1657|Compound:st012939|FD-Score:6.87|P-value:1.01E-9 ID:SGTC_1713|Compound:st033146|FD-Score:-4.08|P-value:1.71E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.37|P-value:5.41E-11 ID:SGTC_1826|Compound:st055655|FD-Score:4.26|P-value:1.01E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.94|P-value:1.07E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.87|P-value:3.69E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.62|P-value:7.93E-4 ID:SGTC_1931|Compound:st074438|FD-Score:5.47|P-value:9.14E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.68|P-value:6.66E-4 ID:SGTC_2004|Compound:4023728|FD-Score:5.80|P-value:2.06E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-5.11|P-value:3.79E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-4.61|P-value:2.68E-5 ID:SGTC_2024|Compound:5144227|FD-Score:4.75|P-value:1.73E-5 ID:SGTC_2043|Compound:5101342|FD-Score:6.73|P-value:2.06E-9 ID:SGTC_2052|Compound:5265182|FD-Score:4.72|P-value:1.89E-5 ID:SGTC_2058|Compound:5236698|FD-Score:5.03|P-value:5.62E-6 ID:SGTC_2068|Compound:5226020|FD-Score:5.35|P-value:1.51E-6 ID:SGTC_2077|Compound:5212015|FD-Score:4.00|P-value:2.43E-4 ID:SGTC_2088|Compound:5278280|FD-Score:12.20|P-value:6.81E-27 ID:SGTC_2111|Compound:5486399|FD-Score:4.68|P-value:2.23E-5 ID:SGTC_2133|Compound:5320837|FD-Score:5.40|P-value:1.22E-6 ID:SGTC_2198|Compound:6589944|FD-Score:8.26|P-value:2.66E-13 ID:SGTC_2205|Compound:7238770|FD-Score:5.73|P-value:2.81E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.99|P-value:1.48E-12 ID:SGTC_2259|Compound:7964009|FD-Score:17.10|P-value:1.19E-50 ID:SGTC_2313|Compound:7726885|FD-Score:3.55|P-value:9.91E-4 ID:SGTC_2356|Compound:9061756|FD-Score:4.54|P-value:3.79E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.29|P-value:9.01E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.74|P-value:5.51E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.06|P-value:1.97E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.61|P-value:8.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.08|P-value:1.90E-4 ID:SGTC_2681|Compound:menadione|FD-Score:15.00|P-value:8.89E-40 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.16|P-value:1.43E-4 ID:SGTC_2781|Compound:5567276|FD-Score:6.43|P-value:9.84E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-5.58|P-value:4.97E-7 ID:SGTC_2937|Compound:9044753|FD-Score:3.69|P-value:6.44E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.00|P-value:2.42E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.99|P-value:2.32E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.63|P-value:7.79E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.80|P-value:4.64E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.56|P-value:8.86E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.53|P-value:9.90E-4

Top fitness defect scores for YHR206W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2259 7964009 17.10 200.0 µM 1.19E-50 superoxide 1 1.14E-65
2 SGTC_1556 plumbagin 17.00 1.5 µM 2.65E-50 superoxide 2 3.26E-65
3 SGTC_2681 menadione 15.00 3.2 µM 8.89E-40 superoxide 2 1.86E-51
4 SGTC_394 menadione 13.10 8.3 µM 1.17E-30 superoxide 2 1.53E-39
5 SGTC_2088 5278280 12.20 127.4 µM 6.81E-27 1 1.27E-34
6 SGTC_29 0299-0004 12.00 13.0 µM 3.40E-26 2 1.04E-33
7 SGTC_2198 6589944 8.26 200.0 µM 2.66E-13 3 7.02E-17
8 SGTC_2233 sulbentine 7.99 40.4 µM 1.48E-12 14 6.56E-16
9 SGTC_177 1327-0068 7.89 8.4 µM 2.80E-12 14 1.51E-15
10 SGTC_824 1304-0008 7.24 100.0 µM 1.33E-10 DNA damage response 3 2.32E-13
11 SGTC_1657 st012939 6.87 43.4 µM 1.01E-9 1 3.25E-12
12 SGTC_2043 5101342 6.73 149.0 µM 2.06E-9 SWF1 & branched chain AA biosynthesis 3 8.20E-12
13 SGTC_2781 5567276 6.43 71.4 µM 9.84E-9 11 6.28E-11
14 SGTC_1530 rhein 6.02 70.4 µM 7.40E-8 4 8.67E-10
15 SGTC_1844 rapamycin 5.94 4.0 nM 1.07E-7 89 1.41E-9
16 SGTC_2004 4023728 5.80 41.9 µM 2.06E-7 9 3.28E-9
17 SGTC_2205 7238770 5.73 200.0 µM 2.81E-7 1 4.90E-9
18 SGTC_1931 st074438 5.47 57.1 µM 9.14E-7 4 2.28E-8
19 SGTC_2133 5320837 5.40 200.0 µM 1.22E-6 ERG2 7 3.31E-8
20 SGTC_2068 5226020 5.35 147.0 µM 1.51E-6 9 4.38E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.420 1.44E-143 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.308 1.92E-74 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.271 1.27E-57 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.269 8.16E-57 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.253 2.95E-50 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.146 2.37E-17 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.130 4.76E-14 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.126 2.58E-13 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.124 6.58E-13 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.114 4.05E-11 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.110 1.44E-10 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.109 2.08E-10 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.101 4.24E-9 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.100 6.16E-9 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.096 2.18E-8 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock