YHR207C / SET5

Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR207C / SET5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.79|P-value:8.41E-9 ID:SGTC_84|Compound:0443-0269|FD-Score:3.70|P-value:1.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.47|P-value:3.38E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.41|P-value:4.58E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.04|P-value:3.44E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:4.84|P-value:1.18E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:4.98E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.77|P-value:1.68E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.13|P-value:2.91E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.64|P-value:1.87E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.62|P-value:2.08E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.59|P-value:2.59E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:4.41|P-value:8.75E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.08|P-value:3.78E-7 ID:SGTC_680|Compound:0417-1641|FD-Score:4.94|P-value:7.28E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:5.89|P-value:4.72E-9 ID:SGTC_702|Compound:1488-0190|FD-Score:5.03|P-value:4.68E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:5.45|P-value:5.34E-8 ID:SGTC_709|Compound:3807-1509|FD-Score:4.35|P-value:1.12E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.41|P-value:4.48E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.37|P-value:5.26E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.25|P-value:1.63E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.09|P-value:3.61E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.24|P-value:8.03E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.44|P-value:7.76E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.20|P-value:2.06E-7 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.56|P-value:2.63E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.32|P-value:1.31E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.39|P-value:4.76E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.97|P-value:5.55E-5 ID:SGTC_1733|Compound:st037357|FD-Score:6.00|P-value:2.42E-9 ID:SGTC_1736|Compound:st036774|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.21|P-value:2.10E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.98|P-value:5.41E-5 ID:SGTC_1856|Compound:st057054|FD-Score:4.73|P-value:1.99E-6 ID:SGTC_2283|Compound:7944793|FD-Score:-4.24|P-value:1.70E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.23|P-value:8.43E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.99|P-value:5.02E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.83|P-value:9.44E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.58|P-value:4.01E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.61|P-value:2.03E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.43|P-value:4.03E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.35|P-value:5.47E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.20|P-value:8.59E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.91|P-value:7.88E-7 ID:SGTC_2556|Compound:citropten|FD-Score:3.34|P-value:5.75E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.40|P-value:4.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.43|P-value:8.00E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:7.31|P-value:5.14E-13 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.48|P-value:3.50E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.57|P-value:2.59E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.61|P-value:2.17E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.34|P-value:5.37E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.39|P-value:4.84E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.18|P-value:9.23E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.85|P-value:8.85E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-3.49|P-value:3.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.30|P-value:6.24E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.53|P-value:2.92E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.52|P-value:3.06E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.85|P-value:8.79E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.97|P-value:5.63E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.96|P-value:5.75E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.67|P-value:1.75E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.77|P-value:1.65E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-5.43|P-value:5.64E-8 ID:SGTC_3219|Compound:9131112|FD-Score:-4.03|P-value:4.09E-5 ID:SGTC_3234|Compound:9132280|FD-Score:-3.39|P-value:4.56E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.95|P-value:7.06E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.79|P-value:8.41E-9 ID:SGTC_84|Compound:0443-0269|FD-Score:3.70|P-value:1.58E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.47|P-value:3.38E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.41|P-value:4.58E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.04|P-value:3.44E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:4.84|P-value:1.18E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:4.98E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.77|P-value:1.68E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:5.13|P-value:2.91E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.64|P-value:1.87E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.62|P-value:2.08E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.59|P-value:2.59E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:4.41|P-value:8.75E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:3.23|P-value:8.28E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.08|P-value:3.78E-7 ID:SGTC_680|Compound:0417-1641|FD-Score:4.94|P-value:7.28E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:5.89|P-value:4.72E-9 ID:SGTC_702|Compound:1488-0190|FD-Score:5.03|P-value:4.68E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:5.45|P-value:5.34E-8 ID:SGTC_709|Compound:3807-1509|FD-Score:4.35|P-value:1.12E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.41|P-value:4.48E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.37|P-value:5.26E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.25|P-value:1.63E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.09|P-value:3.61E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.24|P-value:8.03E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.44|P-value:7.76E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.20|P-value:2.06E-7 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.56|P-value:2.63E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.32|P-value:1.31E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.39|P-value:4.76E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.97|P-value:5.55E-5 ID:SGTC_1733|Compound:st037357|FD-Score:6.00|P-value:2.42E-9 ID:SGTC_1736|Compound:st036774|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.21|P-value:2.10E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.98|P-value:5.41E-5 ID:SGTC_1856|Compound:st057054|FD-Score:4.73|P-value:1.99E-6 ID:SGTC_2283|Compound:7944793|FD-Score:-4.24|P-value:1.70E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.23|P-value:8.43E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.99|P-value:5.02E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.83|P-value:9.44E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.58|P-value:4.01E-6 ID:SGTC_2322|Compound:7413319|FD-Score:-3.61|P-value:2.03E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.43|P-value:4.03E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.35|P-value:5.47E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.20|P-value:8.59E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.91|P-value:7.88E-7 ID:SGTC_2556|Compound:citropten|FD-Score:3.34|P-value:5.75E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.40|P-value:4.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.43|P-value:8.00E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:7.31|P-value:5.14E-13 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.48|P-value:3.50E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.57|P-value:2.59E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.61|P-value:2.17E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.34|P-value:5.37E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.39|P-value:4.84E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.18|P-value:9.23E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.85|P-value:8.85E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-3.49|P-value:3.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.30|P-value:6.24E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.53|P-value:2.92E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.52|P-value:3.06E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.85|P-value:8.79E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.97|P-value:5.63E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.96|P-value:5.75E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.67|P-value:1.75E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.77|P-value:1.65E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-5.43|P-value:5.64E-8 ID:SGTC_3219|Compound:9131112|FD-Score:-4.03|P-value:4.09E-5 ID:SGTC_3234|Compound:9132280|FD-Score:-3.39|P-value:4.56E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.95|P-value:7.06E-7

Top fitness defect scores for YHR207C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 7.31 87.9 µM 5.14E-13 cell wall 51 1.33E-13
2 SGTC_138 0850-0259 7.04 40.9 µM 3.44E-12 cell wall 74 9.78E-13
3 SGTC_1733 st037357 6.00 54.9 µM 2.42E-9 60S ribosome export 4 9.58E-10
4 SGTC_695 3505-6186 5.89 243.0 µM 4.72E-9 4 1.93E-9
5 SGTC_58 0957-0393 5.79 9.0 µM 8.41E-9 cell wall 223 3.54E-9
6 SGTC_514 4466-0038 5.59 2.6 nM 2.59E-8 cell wall 89 1.15E-8
7 SGTC_708 3448-5400 5.45 146.0 µM 5.34E-8 12 2.46E-8
8 SGTC_1266 0828-0227 5.20 32.9 µM 2.06E-7 6 1.02E-7
9 SGTC_312 4092-0653 5.13 6.8 µM 2.91E-7 ergosterol depletion effects on membrane 51 1.46E-7
10 SGTC_1117 retinoic acid 5.09 1.1 µM 3.61E-7 6 1.83E-7
11 SGTC_673 1082-0474 5.08 110.0 µM 3.78E-7 RSC complex & mRNA processing 34 1.92E-7
12 SGTC_702 1488-0190 5.03 94.0 µM 4.68E-7 amide catabolism 3 2.41E-7
13 SGTC_3255 9139072 4.95 49.5 µM 7.06E-7 4 3.70E-7
14 SGTC_680 0417-1641 4.94 114.0 µM 7.28E-7 RPP1 & pyrimidine depletion 4 3.82E-7
15 SGTC_168 3970-0862 4.84 530.5 µM 1.18E-6 76 6.36E-7
16 SGTC_3210 9128157 4.77 49.5 µM 1.65E-6 28 9.01E-7
17 SGTC_236 1509-0011 4.77 5.3 µM 1.68E-6 337 9.18E-7
18 SGTC_1856 st057054 4.73 55.7 µM 1.99E-6 16 1.10E-6
19 SGTC_2320 7373003 4.58 200.0 µM 4.01E-6 12 2.29E-6
20 SGTC_1242 0402-0103 4.44 60.1 µM 7.76E-6 19 4.58E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.257 1.23E-51 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.256 2.00E-51 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.255 7.40E-51 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.244 7.33E-47 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.230 1.86E-41 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.229 3.51E-41 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.214 3.31E-36 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.211 5.19E-35 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.210 9.19E-35 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.197 8.57E-31 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.181 3.28E-26 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.181 4.72E-26 YHR141C RPL42B hom Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication
0.178 3.24E-25 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.176 9.77E-25 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.174 3.05E-24 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication