HIPHOP chemogenomics database
YHR210C_p 
Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR210C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.100 | 6.21E-9 | YGL098W | USE1 | het | Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p |
| 0.081 | 2.78E-6 | YKL053C-A | MDM35 | hom | Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress |
| 0.078 | 6.43E-6 | YOL076W | MDM20 | hom | Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly |
| 0.076 | 9.65E-6 | YJL075C_d | APQ13_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate |
| 0.075 | 1.30E-5 | YPL242C | IQG1 | het | Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.072 | 3.34E-5 | YLR148W | PEP3 | hom | Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis |
| 0.071 | 3.91E-5 | YIL095W | PRK1 | hom | Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication |
| 0.071 | 4.12E-5 | YNL311C | SKP2 | hom | F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments |
| 0.070 | 5.16E-5 | YPL168W_p | YPL168W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated |
| 0.068 | 8.51E-5 | YJR046W | TAH11 | het | DNA replication licensing factor, required for pre-replication complex assembly |
| 0.067 | 1.05E-4 | YER051W | JHD1 | hom | JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe |
| 0.066 | 1.37E-4 | YHR024C | MAS2 | het | Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins |
| 0.066 | 1.42E-4 | YLR453C | RIF2 | hom | Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation |
| 0.065 | 1.48E-4 | YPL266W | DIM1 | het | Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing |
| 0.065 | 1.74E-4 | YOR116C | RPO31 | het | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |