YHR210C_p

Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR210C / YHR210C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.04|P-value:9.35E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.67|P-value:9.57E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.76|P-value:5.84E-5 ID:SGTC_489|Compound:paxilline|FD-Score:3.18|P-value:6.20E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.95|P-value:2.91E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:4.60|P-value:1.44E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.19|P-value:5.46E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.63|P-value:9.94E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.97|P-value:2.15E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.18|P-value:5.55E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.34|P-value:3.42E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.52|P-value:1.75E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.13|P-value:7.45E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.53|P-value:1.68E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.12|P-value:1.39E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:-3.10|P-value:7.49E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.22|P-value:5.28E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.69|P-value:9.20E-7 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.14|P-value:7.07E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.22|P-value:5.42E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.98|P-value:2.64E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.02|P-value:9.72E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.38|P-value:4.28E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.54|P-value:1.45E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.33|P-value:3.24E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.63|P-value:9.96E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.26|P-value:4.39E-8 ID:SGTC_1697|Compound:st025554|FD-Score:3.68|P-value:9.26E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.14|P-value:6.48E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.95|P-value:2.95E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.05|P-value:8.94E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.44|P-value:2.34E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.16|P-value:6.66E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.91|P-value:3.03E-7 ID:SGTC_2397|Compound:5161689|FD-Score:-3.55|P-value:1.38E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-6.34|P-value:4.53E-11 ID:SGTC_2476|Compound:5806916|FD-Score:3.14|P-value:7.25E-4 ID:SGTC_2477|Compound:5967686|FD-Score:7.11|P-value:2.23E-13 ID:SGTC_2481|Compound:5478948|FD-Score:5.39|P-value:2.06E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.35|P-value:3.02E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.32|P-value:5.48E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.42|P-value:2.29E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.71|P-value:2.71E-9 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.29|P-value:4.21E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.02|P-value:2.20E-5 ID:SGTC_2889|Compound:9059656|FD-Score:-4.25|P-value:6.89E-6 ID:SGTC_2891|Compound:9063876|FD-Score:3.24|P-value:4.99E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.80|P-value:5.56E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.07|P-value:9.11E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.97|P-value:2.68E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.40|P-value:3.92E-6 ID:SGTC_3132|Compound:9126706|FD-Score:4.77|P-value:6.20E-7 ID:SGTC_3136|Compound:9095672|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.66|P-value:1.06E-6 ID:SGTC_3214|Compound:9129694|FD-Score:3.31|P-value:3.87E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.21|P-value:9.30E-6 ID:SGTC_3291|Compound:9121177|FD-Score:-3.42|P-value:2.27E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.62|P-value:1.05E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.44|P-value:3.13E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.68|P-value:9.14E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.04|P-value:9.35E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.67|P-value:9.57E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.76|P-value:5.84E-5 ID:SGTC_489|Compound:paxilline|FD-Score:3.18|P-value:6.20E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.95|P-value:2.91E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:4.60|P-value:1.44E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.19|P-value:5.46E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.63|P-value:9.94E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.97|P-value:2.15E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.18|P-value:5.55E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.34|P-value:3.42E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.52|P-value:1.75E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.13|P-value:7.45E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.53|P-value:1.68E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:4.12|P-value:1.39E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:-3.10|P-value:7.49E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.22|P-value:5.28E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.69|P-value:9.20E-7 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.14|P-value:7.07E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.22|P-value:5.42E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.98|P-value:2.64E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.02|P-value:9.72E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:4.38|P-value:4.28E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.54|P-value:1.45E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.33|P-value:3.24E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.63|P-value:9.96E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.26|P-value:4.39E-8 ID:SGTC_1697|Compound:st025554|FD-Score:3.68|P-value:9.26E-5 ID:SGTC_1815|Compound:st051655|FD-Score:-3.14|P-value:6.48E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.95|P-value:2.95E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.05|P-value:8.94E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.44|P-value:2.34E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.16|P-value:6.66E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.91|P-value:3.03E-7 ID:SGTC_2397|Compound:5161689|FD-Score:-3.55|P-value:1.38E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-6.34|P-value:4.53E-11 ID:SGTC_2476|Compound:5806916|FD-Score:3.14|P-value:7.25E-4 ID:SGTC_2477|Compound:5967686|FD-Score:7.11|P-value:2.23E-13 ID:SGTC_2481|Compound:5478948|FD-Score:5.39|P-value:2.06E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.35|P-value:3.02E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.32|P-value:5.48E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.42|P-value:2.29E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.71|P-value:2.71E-9 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.29|P-value:4.21E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.02|P-value:2.20E-5 ID:SGTC_2889|Compound:9059656|FD-Score:-4.25|P-value:6.89E-6 ID:SGTC_2891|Compound:9063876|FD-Score:3.24|P-value:4.99E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.80|P-value:5.56E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.07|P-value:9.11E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.97|P-value:2.68E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.40|P-value:3.92E-6 ID:SGTC_3132|Compound:9126706|FD-Score:4.77|P-value:6.20E-7 ID:SGTC_3136|Compound:9095672|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.66|P-value:1.06E-6 ID:SGTC_3214|Compound:9129694|FD-Score:3.31|P-value:3.87E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.21|P-value:9.30E-6 ID:SGTC_3291|Compound:9121177|FD-Score:-3.42|P-value:2.27E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.62|P-value:1.05E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.44|P-value:3.13E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.68|P-value:9.14E-5

Top fitness defect scores for YHR210C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2477 5967686 7.11 25.2 µM 2.23E-13 2 5.67E-13
2 SGTC_2481 5478948 5.39 45.2 µM 2.06E-8 PDR1 11 3.48E-8
3 SGTC_1674 st016616 5.26 23.6 µM 4.39E-8 6 7.23E-8
4 SGTC_730 1436-0052 4.97 41.2 µM 2.15E-7 mitochondrial processes 2 3.34E-7
5 SGTC_2396 5342950 4.91 42.8 µM 3.03E-7 RSC complex & mRNA processing 25 4.66E-7
6 SGTC_3132 9126706 4.77 49.5 µM 6.20E-7 9 9.31E-7
7 SGTC_1126 isoteolin 4.69 1.0 µM 9.20E-7 14 1.36E-6
8 SGTC_3204 9114183 4.66 49.5 µM 1.06E-6 17 1.56E-6
9 SGTC_674 0498-0004 4.60 451.0 µM 1.44E-6 heme requiring 12 2.09E-6
10 SGTC_3305 9127027 4.44 53.8 µM 3.13E-6 10 4.44E-6
11 SGTC_3002 9075603 4.40 71.4 µM 3.92E-6 11 5.51E-6
12 SGTC_1578 josamycin 4.38 24.2 µM 4.28E-6 8 6.01E-6
13 SGTC_2544 sphondin 4.32 68.5 µM 5.48E-6 RNA pol III & RNase P/MRP 16 7.63E-6
14 SGTC_3245 9134821 4.21 49.5 µM 9.30E-6 12 1.27E-5
15 SGTC_1101 ebselen 4.12 5.3 µM 1.39E-5 20 1.87E-5
16 SGTC_2802 7925815 4.02 54.5 µM 2.20E-5 40 2.92E-5
17 SGTC_1454 4239-0054 3.98 42.6 µM 2.64E-5 38 3.48E-5
18 SGTC_2947 9072639 3.97 7.7 µM 2.68E-5 tubulin folding & SWR complex 41 3.53E-5
19 SGTC_632 0781-2353 3.95 4.7 µM 2.91E-5 Golgi 44 3.83E-5
20 SGTC_2016 5121758 3.95 140.0 µM 2.95E-5 redox potentiating 52 3.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.21E-9 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.081 2.78E-6 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.078 6.43E-6 YOL076W MDM20 hom Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
0.076 9.65E-6 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.075 1.30E-5 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.072 3.34E-5 YLR148W PEP3 hom Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
0.071 3.91E-5 YIL095W PRK1 hom Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication
0.071 4.12E-5 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.070 5.16E-5 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
0.068 8.51E-5 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.067 1.05E-4 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.066 1.37E-4 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.066 1.42E-4 YLR453C RIF2 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.065 1.48E-4 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.065 1.74E-4 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21